Type 1 Diabetes Intervention Trials: What Have We Learned? A Critical Review of Selected Intervention Trials

2002 ◽  
Vol 104 (2) ◽  
pp. 97-104 ◽  
Author(s):  
Carla J. Greenbaum
Keyword(s):  
Type 1 Diabetes ◽  
Critical Review ◽  
Diabetes Intervention ◽  
Intervention Trials

Type 1 diabetes intervention trials

2001 ◽  
Vol 2 (1) ◽  
pp. 2-11 ◽  
Author(s):  
Massimo Pietropaolo ◽  
Dorothy J Becker
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Intervention ◽  
Intervention Trials

Type 1 diabetes intervention trials

2001 ◽  
Vol 2 (1) ◽  
pp. 2-11
Author(s):  
Massimo Pietropaolo ◽  
Dorothy J Becker
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Intervention ◽  
Intervention Trials

scholarly journals Future Intervention Trials in Type 1 Diabetes

Diabetes Care ◽  
2004 ◽  
Vol 27 (4) ◽  
pp. 996-997 ◽  
Author(s):  
T. Wilkin ◽  
J. Ludvigsson ◽  
C. Greenbaum ◽  
J. Palmer ◽  
D. Becker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Intervention Trials

scholarly journals The Effect of Ethnicity in the Rate of Beta-Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis

2020 ◽  
Vol 105 (12) ◽  
pp. e4393-e4406 ◽  
Author(s):  
Mustafa Tosur ◽  
Mario A Cleves ◽  
Jay M Sosenko ◽  
Ingrid Libman ◽  
David A Baidal ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Clinical Diagnosis ◽  
Area Under The Curve ◽  
Diabetes Diagnosis ◽  
Z Score ◽  
C Peptide ◽  
Functional Loss ◽  
Intervention Trials

Abstract Objective We set forth to compare ethnicities for metabolic and immunological characteristics at the clinical diagnosis of type 1 diabetes (T1D) and assess the effect of ethnicity on beta-cell functional loss within 3 years after clinical diagnosis. Research Methods and Design We studied participants in TrialNet New Onset Intervention Trials (n = 624, median age = 14.4 years, 58% male, 8.7% Hispanic) and followed them prospectively for 3 years. Mixed meal tolerance tests (MMTT) were performed within 6 months following clinical diagnosis and repeated semiannually. Unless otherwise indicated, analyses were adjusted for age, sex, BMI Z-score, and diabetes duration. Results At T1D clinical diagnosis, Hispanics, compared with non-Hispanic whites (NHW), had a higher frequency of diabetic ketoacidosis (DKA) (44.7% vs 25.3%, OR = 2.36, P = 0.01), lower fasting glucose (97 vs 109 mg/dL, P = 0.02) and higher fasting C-peptide (1.23 vs 0.94 ng/mL, P = 0.02) on the first MMTT, and higher frequency of ZnT8 autoantibody positivity (n = 201, 94.1% vs 64%, OR = 7.98, P = 0.05). After exclusion of participants in experimental arms of positive clinical trials, C-peptide area under the curve (AUC) trajectories during the first 3 years after clinical diagnosis were not significantly different between Hispanics and NHW after adjusting for age, sex, BMI-z score, and DKA (n = 413, P = 0.14). Conclusion Despite differences in the metabolic and immunological characteristics at clinical diagnosis of T1D between Hispanics and NHW, C-peptide trajectories did not differ significantly in the first 3 years following clinical diagnosis after adjustment for body mass index and other confounders. These findings may inform the design of observational studies and intervention trials in T1D.

scholarly journals Guidelines for Intervention Trials in Subjects With Newly Diagnosed Type 1 Diabetes

Diabetes ◽  
2003 ◽  
Vol 52 (5) ◽  
pp. 1059-1065 ◽  
Author(s):  
C. J. Greenbaum ◽  
L. C. Harrison
Keyword(s):  
Type 1 Diabetes ◽  
Newly Diagnosed ◽  
Intervention Trials

scholarly journals Self-management problem solving for adolescents with type 1 diabetes: Intervention processes associated with an Internet program

2011 ◽  
Vol 85 (2) ◽  
pp. 140-142 ◽  
Author(s):  
Shelagh A. Mulvaney ◽  
Russell L. Rothman ◽  
Chandra Y. Osborn ◽  
Cindy Lybarger ◽  
Mary S. Dietrich ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Problem Solving ◽  
Self Management ◽  
Management Problem ◽  
Diabetes Intervention ◽  
Internet Program
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