Current and Past Prevention and Intervention Trials in Type 1 Diabetes

2008 ◽  
pp. 99-112
Author(s):  
Teodora Staeva
Keyword(s):  
Type 1 Diabetes ◽  
Prevention And Intervention ◽  
Intervention Trials

scholarly journals Future Intervention Trials in Type 1 Diabetes

Diabetes Care ◽  
2004 ◽  
Vol 27 (4) ◽  
pp. 996-997 ◽  
Author(s):  
T. Wilkin ◽  
J. Ludvigsson ◽  
C. Greenbaum ◽  
J. Palmer ◽  
D. Becker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Intervention Trials

scholarly journals The Effect of Ethnicity in the Rate of Beta-Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis

2020 ◽  
Vol 105 (12) ◽  
pp. e4393-e4406 ◽  
Author(s):  
Mustafa Tosur ◽  
Mario A Cleves ◽  
Jay M Sosenko ◽  
Ingrid Libman ◽  
David A Baidal ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Clinical Diagnosis ◽  
Area Under The Curve ◽  
Diabetes Diagnosis ◽  
Z Score ◽  
C Peptide ◽  
Functional Loss ◽  
Intervention Trials

Abstract Objective We set forth to compare ethnicities for metabolic and immunological characteristics at the clinical diagnosis of type 1 diabetes (T1D) and assess the effect of ethnicity on beta-cell functional loss within 3 years after clinical diagnosis. Research Methods and Design We studied participants in TrialNet New Onset Intervention Trials (n = 624, median age = 14.4 years, 58% male, 8.7% Hispanic) and followed them prospectively for 3 years. Mixed meal tolerance tests (MMTT) were performed within 6 months following clinical diagnosis and repeated semiannually. Unless otherwise indicated, analyses were adjusted for age, sex, BMI Z-score, and diabetes duration. Results At T1D clinical diagnosis, Hispanics, compared with non-Hispanic whites (NHW), had a higher frequency of diabetic ketoacidosis (DKA) (44.7% vs 25.3%, OR = 2.36, P = 0.01), lower fasting glucose (97 vs 109 mg/dL, P = 0.02) and higher fasting C-peptide (1.23 vs 0.94 ng/mL, P = 0.02) on the first MMTT, and higher frequency of ZnT8 autoantibody positivity (n = 201, 94.1% vs 64%, OR = 7.98, P = 0.05). After exclusion of participants in experimental arms of positive clinical trials, C-peptide area under the curve (AUC) trajectories during the first 3 years after clinical diagnosis were not significantly different between Hispanics and NHW after adjusting for age, sex, BMI-z score, and DKA (n = 413, P = 0.14). Conclusion Despite differences in the metabolic and immunological characteristics at clinical diagnosis of T1D between Hispanics and NHW, C-peptide trajectories did not differ significantly in the first 3 years following clinical diagnosis after adjustment for body mass index and other confounders. These findings may inform the design of observational studies and intervention trials in T1D.

scholarly journals Guidelines for Intervention Trials in Subjects With Newly Diagnosed Type 1 Diabetes

Diabetes ◽  
2003 ◽  
Vol 52 (5) ◽  
pp. 1059-1065 ◽  
Author(s):  
C. J. Greenbaum ◽  
L. C. Harrison
Keyword(s):  
Type 1 Diabetes ◽  
Newly Diagnosed ◽  
Intervention Trials

scholarly journals Genetics and pathogenesis of type 1 diabetes: prospects for prevention and intervention

2011 ◽  
Vol 2 (6) ◽  
pp. 415-420 ◽  
Author(s):  
Hiroshi Ikegami ◽  
Shinsuke Noso ◽  
Naru Babaya ◽  
Yumiko Kawabata
Keyword(s):  
Type 1 Diabetes ◽  
Prevention And Intervention

Cigarette smoking among adolescents with type 1 diabetes: Strategies for behavioral prevention and intervention

2012 ◽  
Vol 26 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Darren Mays ◽  
Randi Streisand ◽  
Leslie R. Walker ◽  
Alexander V. Prokhorov ◽  
Kenneth P. Tercyak
Keyword(s):  
Type 1 Diabetes ◽  
Cigarette Smoking ◽  
Prevention And Intervention ◽  
Behavioral Prevention

scholarly journals Biomarkers for immune intervention trials in type 1 diabetes

2013 ◽  
Vol 149 (3) ◽  
pp. 286-296 ◽  
Author(s):  
Roberto Mallone ◽  
Bart O. Roep
Keyword(s):  
Type 1 Diabetes ◽  
Immune Intervention ◽  
Intervention Trials

164-OR: Efficacy of New-Onset Type 1 Diabetes (T1D) Intervention Trials: Variation in 1-Year Outcomes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 164-OR
Author(s):  
MICHAEL J. HALLER ◽  
MADISON N. GRECO ◽  
DESMOND SCHATZ ◽  
MARK A. ATKINSON ◽  
TODD M. BRUSKO ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Onset Type ◽  
Intervention Trials ◽  
New Onset
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