Decreased T Cell Apoptosis and T Cell Recovery during Highly Active Antiretroviral Therapy (HAART)

2000 ◽  
Vol 97 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Fabrizio Ensoli ◽  
Valeria Fiorelli ◽  
Cecilia Alario ◽  
Maria De Cristofaro ◽  
Donatella Santini Muratori ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Apoptosis ◽  
Highly Active Antiretroviral Therapy ◽  
Cell Recovery ◽  
T Cell Apoptosis ◽  
Highly Active

T-cell apoptosis in HIV-1–infected individuals receiving highly active antiretroviral therapy

Blood ◽  
2001 ◽  
Vol 97 (6) ◽  
pp. 1898-1901 ◽  
Author(s):  
Thomas Böhler ◽  
Klaus-Michael Debatin ◽  
Uwe Wintergerst
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Apoptosis ◽  
Highly Active Antiretroviral Therapy ◽  
T Cell Apoptosis ◽  
Highly Active ◽  
Hiv 1

The Fas/FasL System and T Cell Apoptosis in HIV-1-Infected Lymphoid Tissue during Highly Active Antiretroviral Therapy

2001 ◽  
Vol 101 (2) ◽  
pp. 169-179 ◽  
Author(s):  
Anne Ma Dyrhol-Riise ◽  
Gianna Stent ◽  
Bård I. Røsok ◽  
Pål Voltersvik ◽  
Jan Olofsson ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Apoptosis ◽  
Highly Active Antiretroviral Therapy ◽  
Lymphoid Tissue ◽  
T Cell Apoptosis ◽  
Highly Active ◽  
Hiv 1

scholarly journals Interleukin-7 levels before highly active antiretroviral therapy may predict CD4+ T-cell recovery and virological failure in HIV-infected children

2006 ◽  
Vol 57 (4) ◽  
pp. 798-800 ◽  
Author(s):  
Salvador Resino ◽  
Alicia Pérez ◽  
Juan Antonio León ◽  
Mª Dolores Gurbindo ◽  
Mª Ángeles Muñoz-Fernández
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Virological Failure ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Cell Recovery ◽  
Interleukin 7 ◽  
Highly Active

Predicting the magnitude of short-term CD4+ T-cell recovery in HIV-infected patients during first-line highly active antiretroviral therapy

2010 ◽  
Vol 15 (2) ◽  
pp. 165-175 ◽  
Author(s):  
Antonella Castagna ◽  
Laura Galli ◽  
Carlo Torti ◽  
Antonella D’Arminio Monforte ◽  
Cristina Mussini ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Cell Recovery ◽  
First Line ◽  
Short Term ◽  
Highly Active

scholarly journals Antigen-driven CD4+ T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy

1999 ◽  
Vol 96 (26) ◽  
pp. 15167-15172 ◽  
Author(s):  
N. M. Ferguson ◽  
F. deWolf ◽  
A. C. Ghani ◽  
C. Fraser ◽  
C. A. Donnelly ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Viral Replication ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Highly Active ◽  
Hiv 1

scholarly journals Untangling the Immunological Implications of Nadir on CD4+ Cell Recovery during Suppressive Highly Active Antiretroviral Therapy

2008 ◽  
Vol 46 (1) ◽  
pp. 149-150 ◽  
Author(s):  
L. Ferraris ◽  
G. M. Bellistri ◽  
V. Pegorer ◽  
C. Tincati ◽  
L. Meroni ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Cell Recovery ◽  
Highly Active ◽  
Cd4 Cell

scholarly journals Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus Type 1-Infected Children: Analysis of Cellular Immune Responses

2001 ◽  
Vol 8 (5) ◽  
pp. 943-948 ◽  
Author(s):  
Vesna Blazevic ◽  
Shirley Jankelevich ◽  
Seth M. Steinberg ◽  
Freda Jacobsen ◽  
Robert Yarchoan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Delayed Type Hypersensitivity ◽  
Strong Increase ◽  
Highly Active ◽  
Cell Counts ◽  
Immunodeficiency Virus

ABSTRACT The present study analyzes the effect of highly active antiretroviral therapy (HAART) on restoration of cellular immunity in human immunodeficiency virus (HIV)-infected children over a 24-week period following initiation of HAART with ritonavir, nevirapine, and stavudine. The immunological parameters evaluated at four time points (at enrollment and at 4, 12, and 24 weeks of therapy) included cytokine production by monocytes as well as T-cell proliferation in response to mitogen, alloantigen, and recall antigens including HIV type 1 envelope peptides. Circulating levels of interleukin-16 (IL-16) were measured, in addition to CD4+ T-cell counts, plasma HIV RNA levels, and the delayed-type hypersensitivity (DTH) response. At enrollment the children exhibited defects in several immune parameters measured. Therapy increased CD4+ T-cell counts and decreased viral loads significantly. By contrast, the only immunological parameter that was significantly increased was IL-12 p70 production by monocytes; the DTH response to Candida albicans also showed a strong increase in patients becoming positive. In conclusion, these results demonstrate that HAART in HIV-infected children affects the dynamics of HIV replication and the CD4+ T-cell count over 24 weeks, similar to the pattern seen in HIV-infected adults. Furthermore, these data indicate improvement in antigen-presenting cell immunological function in HIV-infected children induced by HAART.

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