Predicting the magnitude of short-term CD4+ T-cell recovery in HIV-infected patients during first-line highly active antiretroviral therapy

2010 ◽  
Vol 15 (2) ◽  
pp. 165-175 ◽  
Author(s):  
Antonella Castagna ◽  
Laura Galli ◽  
Carlo Torti ◽  
Antonella D’Arminio Monforte ◽  
Cristina Mussini ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Cell Recovery ◽  
First Line ◽  
Short Term ◽  
Highly Active

scholarly journals Interleukin-7 levels before highly active antiretroviral therapy may predict CD4+ T-cell recovery and virological failure in HIV-infected children

2006 ◽  
Vol 57 (4) ◽  
pp. 798-800 ◽  
Author(s):  
Salvador Resino ◽  
Alicia Pérez ◽  
Juan Antonio León ◽  
Mª Dolores Gurbindo ◽  
Mª Ángeles Muñoz-Fernández
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Virological Failure ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Cell Recovery ◽  
Interleukin 7 ◽  
Highly Active

scholarly journals Antigen-driven CD4+ T cell and HIV-1 dynamics: Residual viral replication under highly active antiretroviral therapy

1999 ◽  
Vol 96 (26) ◽  
pp. 15167-15172 ◽  
Author(s):  
N. M. Ferguson ◽  
F. deWolf ◽  
A. C. Ghani ◽  
C. Fraser ◽  
C. A. Donnelly ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Viral Replication ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Highly Active ◽  
Hiv 1

scholarly journals Persistence of Genital Tract T Cell Responses in HIV-Infected Women on Highly Active Antiretroviral Therapy

2010 ◽  
Vol 84 (20) ◽  
pp. 10765-10772 ◽  
Author(s):  
Nonhlanhla N. Mkhize ◽  
Pamela P. Gumbi ◽  
Lenine J. Liebenberg ◽  
Yuan Ren ◽  
Peter Smith ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Genital Tract ◽  
T Cell Responses ◽  
Antiretroviral Drugs ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Highly Active ◽  
Cell Counts

ABSTRACT Initiation of highly active antiretroviral therapy (HAART) for HIV-infected individuals is associated with control of viremia, improved CD4 counts, and declining systemic HIV-specific immune responses. While HAART effectively reduces plasma viremia, it remains unclear how effectively antiretroviral drugs reach mucosal surfaces, such as those of the genital tract. The aim of this study was to determine the effect of HAART on genital tract CD4 T cell reconstitution, HIV shedding, and HIV-specific T cell responses. Cervical cytobrush and blood specimens were obtained from 35 HIV-infected, HAART-naïve women and 27 women on HAART in order to investigate HIV Gag-specific T cell responses by intracellular gamma interferon (IFN-γ) staining. Interleukin 1β (IL-1β), IL-6, and IL-8 concentrations were measured by enzyme-linked immunosorbent assays (ELISA). We show that for HIV-infected women, HAART is associated with significantly improved CD4 T cell counts both in blood and at the cervix. While HAART effectively suppressed both blood and cervical viremia, HIV-specific CD8 T cell responses in blood were lost, while those at the cervix were preserved.

scholarly journals Impact of highly active antiretroviral therapy initiation on CD4+ T-cell repopulation in duodenal and rectal mucosa

AIDS ◽  
2013 ◽  
Vol 27 (6) ◽  
pp. 867-877 ◽  
Author(s):  
Timothy L. Hayes ◽  
David M. Asmuth ◽  
J. William Critchfield ◽  
Thomas H. Knight ◽  
Bridget E. McLaughlin ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Rectal Mucosa ◽  
Cd4 T Cell ◽  
Highly Active ◽  
Therapy Initiation ◽  
Cell Repopulation

Bcl-2 expression is moderately correlated with long-term variability of CD4 T-cell increase under successful highly active antiretroviral therapy

AIDS ◽  
2003 ◽  
Vol 17 (1) ◽  
pp. 141-143 ◽  
Author(s):  
Maria Cristina Uccelli ◽  
Carlo Torti ◽  
Eugenia Quiros-Roldan ◽  
Carmine Tinelli ◽  
Andrea Patroni ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Cd4 T Cell ◽  
Highly Active
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