Collaborative Study on Test Systems to Assess Toxicity of Whole Cell Pertussis Vaccine

Biologicals ◽  
1997 ◽  
Vol 25 (1) ◽  
pp. 41-57 ◽  
Author(s):  
Ineke van Straaten-van de Kappelle ◽  
Johan W. van der Gun ◽  
Frits R. Marsman ◽  
Coenraad F.M. Hendriksen ◽  
Huib J.M. van de Donk
Keyword(s):  
Pertussis Vaccine ◽  
Collaborative Study ◽  
Whole Cell ◽  
Test Systems

Primary Immunization of Infants With an Acellular Pertussis Vaccine in a Double-Blind Randomized Clinical Trial

PEDIATRICS ◽  
1988 ◽  
Vol 82 (3) ◽  
pp. 293-299
Author(s):  
Margareta Blennow ◽  
Marta Granström ◽  
Eva Jäätmaa ◽  
Patrick Olin
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Pertussis Vaccine ◽  
Acellular Pertussis Vaccine ◽  
Cell Vaccine ◽  
Primary Immunization ◽  
Double Blind ◽  
Whole Cell ◽  
Whole Cell Vaccine ◽  
Acellular Vaccine

The rate of adverse reactions and the immunogenicity of a two-component acellular pertussis vaccine as compared with a plain whole-cell vaccine and a placebo were evaluated for primary immunization in 319 6-month-old infants in a double-blind randomized clinical trial. The acellular vaccine produced few and mild systemic and local reactions. Fever (≥38°C) occurred in 6% to 8% of acellular vaccinees as opposed to 25% to 37% of whole-cell vaccinees. Redness (≥1 cm) appeared in 2% to 13% of the acellular vaccine and 24% to 32% of the whole-cell vaccine recipients. Antibody response to pertussis toxin measured in a neutralization test was obtained in 97% to 100% of the infants receiving either two or three doses of the acellular vaccine as compared to 59% after three doses of whole-cell vaccine.

Revisiting the possibility of serious adverse events from the whole cell pertussis vaccine: Were metabolically vulnerable children at risk?

2010 ◽  
Vol 74 (1) ◽  
pp. 150-154 ◽  
Author(s):  
Kumanan Wilson ◽  
Beth Potter ◽  
Douglas Manuel ◽  
Jennifer Keelan ◽  
Pranesh Chakraborty
Keyword(s):  
At Risk ◽  
Adverse Events ◽  
Pertussis Vaccine ◽  
Children At Risk ◽  
Vulnerable Children ◽  
Serious Adverse Events ◽  
Whole Cell

In vitro innate immune cell based models to assess whole cell Bordetella pertussis vaccine quality: A proof of principle

Biologicals ◽  
2015 ◽  
Vol 43 (2) ◽  
pp. 100-109 ◽  
Author(s):  
M.E. Hoonakker ◽  
L.M. Verhagen ◽  
C.F.M. Hendriksen ◽  
C.A.C.M. van Els ◽  
R.J. Vandebriel ◽  
...  
Keyword(s):  
Pertussis Vaccine ◽  
Bordetella Pertussis ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Whole Cell ◽  
Proof Of Principle

Evaluation of the Pertussis Components of Diphtheria-Tetanus-Pertussis Vaccine

PEDIATRICS ◽  
1983 ◽  
Vol 71 (2) ◽  
pp. 200-205
Author(s):  
M. Dianne Murphy ◽  
Jeane Rasnack ◽  
Harold D. Dickson ◽  
Marc Dietch ◽  
Philip A. Brunell
Keyword(s):  
Pertussis Vaccine ◽  
Geometric Mean ◽  
Aluminum Phosphate ◽  
The United States ◽  
Geometric Mean Titer ◽  
Whole Cell ◽  
Pertussis Antigen ◽  
Dtp Vaccine ◽  
Local Reactions ◽  
The Individual

The adjuvant and antigen components of the pertussis fraction of diphtheria-tetanus-pertussis (DTP) vaccine were evaluated. Four preparations of DTP vaccine composed of either whole cell (Wc) or extracted (E) pertussis antigen combined with either an aluminum phosphate (Ph) or alum (Al) adjuvant were compared. Local reactions were similar in all four vaccines after the first two immunizations but were significantly increased in incidence and severity following the third immunization with vaccine WcPh. This appeared to be due to the Ph adjuvant rather than the antigen component. Febrile reactions were experienced more often (P = .0009) and with higher temperatures (P = .0001) with the WcPh vaccine following the first immunization. This appeared to be due to the Wc component. Comparing the pooled Wc groups with the pooled E groups revealed a greater febrile response in the Wc group after both the first (P = .0008) and the second (P = .03) immunization. Local reactions appear temporally and etiologically to be distinct from febrile reactions. The pooled Wc antigen group produced a higher geometric mean titer than the pooled E antigen group (P = .05). Serologic responses, with respect to geometric mean titer, were not significantly different among the individual vaccines. This study suggests that the combination of whole cell and aluminum phosphate, which is currently in use in the United States, is probably not the optimal formulation for pertussis vaccine.

Interleukin-1β-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine

2000 ◽  
Vol 111 (1-2) ◽  
pp. 68-76 ◽  
Author(s):  
Christine E Loscher ◽  
Sheila Donnelly ◽  
Kingston H.G Mills ◽  
Marina A Lynch
Keyword(s):  
Pertussis Vaccine ◽  
Interleukin 1Β ◽  
Whole Cell ◽  
Parenteral Immunization
Sign in / Sign up

Export Citation Format

Share Document