Molecular and Functional Roles of Duodenal Cytochrome B (Dcytb) in Iron Metabolism

2002 ◽  
Vol 29 (3) ◽  
pp. 356-360 ◽  
Author(s):  
G.O. Latunde-Dada ◽  
J. Van der Westhuizen ◽  
C.D. Vulpe ◽  
G.J. Anderson ◽  
R.J. Simpson ◽  
...  
Keyword(s):  
Cytochrome B ◽  
Iron Metabolism ◽  
Functional Roles ◽  
Duodenal Cytochrome B

scholarly journals Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation

Nutrients ◽  
2015 ◽  
Vol 7 (4) ◽  
pp. 2274-2296 ◽  
Author(s):  
Darius Lane ◽  
Dong-Hun Bae ◽  
Angelica Merlot ◽  
Sumit Sahni ◽  
Des Richardson
Keyword(s):  
Cytochrome B ◽  
Iron Metabolism ◽  
Duodenal Cytochrome B

Duodenal cytochrome B and hephaestin expression in patients with iron deficiency and hemochromatosis

2003 ◽  
Vol 125 (3) ◽  
pp. 746-754 ◽  
Author(s):  
Heinz Zoller ◽  
Igor Theurl ◽  
Robert O. Koch ◽  
Andrew T. Mckie ◽  
Wolfgang Vogel ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Cytochrome B ◽  
Duodenal Cytochrome B

Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity

Neuroscience ◽  
2013 ◽  
Vol 245 ◽  
pp. 179-190 ◽  
Author(s):  
S.-Y. Loke ◽  
N.J. Siddiqi ◽  
A.S. Alhomida ◽  
H.-C. Kim ◽  
W.-Y. Ong
Keyword(s):  
Cytochrome B ◽  
Rat Hippocampus ◽  
Duodenal Cytochrome B

Immunolocalization of duodenal cytochrome B: a relationship with circulating markers of iron status

2006 ◽  
Vol 36 (12) ◽  
pp. 890-898 ◽  
Author(s):  
A. C. Y. Li ◽  
A. Warley ◽  
V. Thoree ◽  
R. J. Simpson ◽  
A. T. Mckie ◽  
...  
Keyword(s):  
Cytochrome B ◽  
Iron Status ◽  
Circulating Markers ◽  
Duodenal Cytochrome B

Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells

2006 ◽  
Vol 291 (2) ◽  
pp. L272-L280 ◽  
Author(s):  
Jennifer L. Turi ◽  
Xinchao Wang ◽  
Andrew T. McKie ◽  
Eva Nozik-Grayck ◽  
Lisa B. Mamo ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Cytochrome B ◽  
Iron Transport ◽  
Iron Concentration ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Cellular Iron ◽  
Duodenal Cytochrome B

Catalytically active iron in the lung causes oxidative stress and promotes microbial growth that can be limited by intracellular sequestration of iron within ferritin. Because cellular iron uptake requires membrane ferrireductase activity that in the gut can be provided by duodenal cytochrome b (Dcytb), we sought Dcytb in the lung to test the hypothesis that it contributes to epithelial iron regulation by reducing Fe3+ for cellular iron transport. Dcytb expression was found in respiratory epithelium in vitro and in vivo and was responsive to iron concentration. Iron transport was measured in human bronchial epithelial (HBE) cells using inductively coupled plasma atomic emission spectroscopy and was demonstrated to be partially inhibited in the presence of Dcytb-blocking antibody, suggesting that Dcytb reduces Fe3+ for cellular iron transport. A definite source of reducing equivalents for Dcytb was sought but not identified. We found no evidence that ascorbate was involved but did demonstrate that O2−· production decreased when Dcytb function was blocked. The presence of Dcytb in airway epithelial cells and its regulation by iron therefore may contribute to pulmonary cytoprotection.

scholarly journals Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism

2008 ◽  
Vol 1777 (3) ◽  
pp. 260-268 ◽  
Author(s):  
Jonathan S. Oakhill ◽  
Sophie J. Marritt ◽  
Elena Garcia Gareta ◽  
Richard Cammack ◽  
Andrew T. McKie
Keyword(s):  
Cytochrome B ◽  
Functional Characterization ◽  
Redox Properties ◽  
Duodenal Cytochrome B ◽  
Ascorbate Metabolism

Duodenal cytochrome b (Cybrd 1) and HIF-2α expression during acute hypoxic exposure in mice

2011 ◽  
Vol 50 (8) ◽  
pp. 699-704 ◽  
Author(s):  
Gladys O. Latunde-Dada ◽  
Lan Xiang ◽  
Robert J. Simpson ◽  
Andrew T. McKie
Keyword(s):  
Cytochrome B ◽  
Hypoxic Exposure ◽  
Duodenal Cytochrome B

scholarly journals Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells

Metallomics ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 1389-1393 ◽  
Author(s):  
F. Schlottmann ◽  
M. Vera-Aviles ◽  
G. O. Latunde-Dada
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Cytochrome B ◽  
Cho Cells ◽  
Reductase Activity ◽  
Ferric Reductase ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Functional Studies ◽  
Duodenal Cytochrome B ◽  
In Cells

A single nucleotide polymorphism (rs10455) in the last exon of the Dcytb gene in C282Y hemochromatosis subjects exhibited increased ferric reductase activity in transgenic CHO cells.

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