scholarly journals Duodenal cytochrome b (Cybrd1) ferric reductase functional studies in cells

Metallomics ◽  
2017 ◽  
Vol 9 (10) ◽  
pp. 1389-1393 ◽  
Author(s):  
F. Schlottmann ◽  
M. Vera-Aviles ◽  
G. O. Latunde-Dada
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Cytochrome B ◽  
Cho Cells ◽  
Reductase Activity ◽  
Ferric Reductase ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Functional Studies ◽  
Duodenal Cytochrome B ◽  
In Cells

A single nucleotide polymorphism (rs10455) in the last exon of the Dcytb gene in C282Y hemochromatosis subjects exhibited increased ferric reductase activity in transgenic CHO cells.

scholarly journals Phenotype of asthmatics with increased airway S-nitrosoglutathione reductase activity

2014 ◽  
Vol 45 (1) ◽  
pp. 87-97 ◽  
Author(s):  
Nadzeya V. Marozkina ◽  
Xin-Qun Wang ◽  
Vitali Stsiapura ◽  
Anne Fitzpatrick ◽  
Silvia Carraro ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Smooth Muscle ◽  
Severe Asthma ◽  
Reductase Activity ◽  
Asthma Diagnosis ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Asthma Patients ◽  
Increased Activity ◽  
Smooth Muscle Relaxant

S-Nitrosoglutathione is an endogenous airway smooth muscle relaxant. Increased airway S-nitrosoglutathione breakdown occurs in some asthma patients. We asked whether patients with increased airway catabolism of this molecule had clinical features that distinguished them from other asthma patients.We measured S-nitrosoglutathione reductase expression and activity in bronchoscopy samples taken from 66 subjects in the Severe Asthma Research Program. We also analysed phenotype and genotype data taken from the program as a whole.Airway S-nitrosoglutathione reductase activity was increased in asthma patients (p=0.032). However, only a subpopulation was affected and this subpopulation was not defined by a “severe asthma” diagnosis. Subjects with increased activity were younger, had higher IgE and an earlier onset of symptoms. Consistent with a link between S-nitrosoglutathione biochemistry and atopy: 1) interleukin 13 increased S-nitrosoglutathione reductase expression and 2) subjects with an S-nitrosoglutathione reductase single nucleotide polymorphism previously associated with asthma had higher IgE than those without this single nucleotide polymorphism. Expression was higher in airway epithelium than in smooth muscle and was increased in regions of the asthmatic lung with decreased airflow.An early-onset, allergic phenotype characterises the asthma population with increased S-nitrosoglutathione reductase activity.

scholarly journals A Single Nucleotide Polymorphism in the MDM2 Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells

2007 ◽  
Vol 67 (6) ◽  
pp. 2757-2765 ◽  
Author(s):  
Wenwei Hu ◽  
Zhaohui Feng ◽  
Lan Ma ◽  
John Wagner ◽  
J. Jeremy Rice ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Nucleotide Polymorphism ◽  
Mdm2 Gene ◽  
Single Nucleotide ◽  
In Cells
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