Hepatocyte Nuclear Factors-1α, -1β, and -3β Expressed in the Gonad of Tilapia (Oreochromis mossambicus)

2001 ◽  
Vol 288 (4) ◽  
pp. 833-840 ◽  
Author(s):  
Wei-Tung Huang ◽  
Hong-Yi Gong ◽  
Cliff Ji-Fan Lin ◽  
Ching-Feng Weng ◽  
Mark Hung-Chih Chen ◽  
...  
Keyword(s):  
Oreochromis Mossambicus ◽  
Nuclear Factors ◽  
Hepatocyte Nuclear Factors

scholarly journals Mutations in transcription factor as rare causes of diabetes in pregnancy

2019 ◽  
Vol 22 (3) ◽  
pp. 274-280 ◽  
Author(s):  
Natalia A. Zubkova ◽  
Fatima F. Burumkulova ◽  
Vasily A. Petrukhin ◽  
Margarita A. Plechanova ◽  
Anton E. Panov ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Glycemic Control ◽  
Pregnant Women ◽  
Clinical Characteristics ◽  
Diabetes In Pregnancy ◽  
Perinatal Complications ◽  
Nuclear Factors ◽  
Hepatocyte Nuclear Factors ◽  
Hnf1a Gene ◽  
In Pregnancy

MODY1 and MODY3 represent rare causes of diabetes in pregnancy. Establishing a molecular diagnosis of MODY1 or MODY3 during pregnancy may be important for minimizing risk of perinatal complications and for improving glycemic control after pregnancy. The objective of the study was to evaluate the contribution of mutations in HNF4A and HNF1A genes in development of diabetes in pregnancy and to describe clinical characteristics of diabetes in pregnancy associated with these mutations. 230 pregnant women (20-43 years) with different type of glucose intolerance complicated during their current pregnancy were included in the study. A custom NGS panel targeting 28 diabetes causative genes was used for sequencing. Heterozygous mutations in HNF4A and HNF1A genes were detected in 3% of cases. Mutations p.I271T in HNF4A gene and p.L148F, p.Y265C, p.G288W in HNF1A gene were novel. This study includes a description of patients with pregnancy diabetes due to mutations in hepatocyte nuclear factors.

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