Insulin-like Growth Factor Type 1 Upregulates Uncoupling Protein 3

2001 ◽  
Vol 287 (5) ◽  
pp. 1105-1111 ◽  
Author(s):  
Helena Gustafsson ◽  
Lars Adamson ◽  
Jan Hedander ◽  
Erik Walum ◽  
Anna Forsby
Keyword(s):  
Growth Factor ◽  
Uncoupling Protein ◽  
Insulin Like Growth Factor ◽  
Uncoupling Protein 3 ◽  
Factor Type

Insulin-like growth factor type 1 prevents hyperglycemia-induced uncoupling protein 3 down-regulation and oxidative stress

2004 ◽  
Vol 77 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Helena Gustafsson ◽  
Therése Söderdahl ◽  
Gunn Jönsson ◽  
Jan-Ove Bratteng ◽  
Anna Forsby
Keyword(s):  
Oxidative Stress ◽  
Growth Factor ◽  
Uncoupling Protein ◽  
Insulin Like Growth Factor ◽  
Down Regulation ◽  
Uncoupling Protein 3 ◽  
Factor Type ◽  
And Oxidative Stress

Production and Characterization of Monoclonal Antibodies Against Insulin-Like Growth Factor Type 1 Receptor

Hybridoma ◽  
2006 ◽  
Vol 25 (4) ◽  
pp. 230-237 ◽  
Author(s):  
Mehrnaz Keyhanfar ◽  
Briony E. Forbes ◽  
Leah J. Cosgrove ◽  
John C. Wallace ◽  
Grant W. Booker
Keyword(s):  
Monoclonal Antibodies ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Factor Type

Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: A predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas

2012 ◽  
Vol 48 (16) ◽  
pp. 3027-3035 ◽  
Author(s):  
Irène Asmane ◽  
Emmanuel Watkin ◽  
Laurent Alberti ◽  
Adeline Duc ◽  
Perrine Marec-Berard ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Growth Factor ◽  
Predictive Biomarker ◽  
Nuclear Staining ◽  
Insulin Like Growth Factor ◽  
Factor Type

Expression of Insulin-like Growth Factor Type 1 Receptor is Linked to Inflammation in Adamantinomatous Craniopharyngioma

2021 ◽  
Author(s):  
Lang Yang ◽  
Kai Li ◽  
Weizhao Li ◽  
Chaohu Wang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
High Expression ◽  
Inflammatory Factors ◽  
Insulin Like Growth Factor ◽  
Factor Type ◽  
Adamantinomatous Craniopharyngioma ◽  
The Relationship ◽  
Igf1r Expression

Introduction Insulin-like growth factor type 1 receptor (IGF1R) is overexpressed in various malignant tumors, which relates to their transformation and recurrence. Craniopharyngioma is a benign tumor with malignant results, often accompanied by a severe inflammatory reaction. However, the relationship between IGF1R expression and the inflammatory response of craniopharyngioma is unclear. Methods We enrolled 85 patients with adamantinomatous craniopharyngioma (ACP) in a study to explore the relationship between IGF1R expression and clinical features of this disease. Results Patients in the IGF1R high expression group had a significantly higher incidence of hypopituitarism, higher recurrence rate and lower progression-free survival. Beta-catenin can further regulate expression of the stem cell marker, CD44, by regulating IGF1R. Using immunofluorescence, we found that tumor stem cell–like cells did not express phosphorylated (p)-ERK, although p-ERK activation was evident in the surrounding cells. Picropodophyllin, a specific inhibitor of IGF1R, increased the expression of p-ERK protein, and decreased the transcription level of interleukin-6. Conclusions High expression of IGF1R might promote inflammation of ACP, which might be an unfavorable factor for pituitary function and prognosis. The high expression of IGF1R in tumor cell stem-like cells might inhibit the expression of p-ERK and promote the generation of inflammatory factors. Insulin-like growth factor type 1 receptor plays a stemness maintenance role in ACP and regulates the production of inflammatory factors through a p-ERK pathway, which suggests that targeting IGF1R and p-ERK might provide a new direction for alleviating tumor inflammation.

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