Oral Exposure of Dimethylarsinic Acid, a Main Metabolite of Inorganic Arsenics, in Mice Leads to an Increase in 8-Oxo-2′-deoxyguanosine Level, Specifically in the Target Organs for Arsenic Carcinogenesis

2001 ◽  
Vol 287 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Kenzo Yamanaka ◽  
Fumiyo Takabayashi ◽  
Mutsumi Mizoi ◽  
Yan An ◽  
Akira Hasegawa ◽  
...  
Keyword(s):  
Oral Exposure ◽  
Dimethylarsinic Acid ◽  
Main Metabolite ◽  
Target Organs ◽  
Inorganic Arsenics

Dimethylarsinic acid, a main metabolite of inorganic arsenics, has tumorigenicity and progression effects in the pulmonary tumors of A/J mice

1998 ◽  
Vol 125 (1-2) ◽  
pp. 83-88 ◽  
Author(s):  
Hiroyuki Hayashi ◽  
Masayoshi Kanisawa ◽  
Kenzo Yamanaka ◽  
Takaaki Ito ◽  
Naoko Udaka ◽  
...  
Keyword(s):  
Dimethylarsinic Acid ◽  
Main Metabolite ◽  
Pulmonary Tumors ◽  
Inorganic Arsenics

scholarly journals Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice

1996 ◽  
Vol 17 (4) ◽  
pp. 767-770 ◽  
Author(s):  
Kenzo Yamanaka ◽  
Kaori Ohtsubo ◽  
Akira Hasegawa ◽  
Hiroyuki Hayashi ◽  
Hiroshi Ohji ◽  
...  
Keyword(s):  
Dimethylarsinic Acid ◽  
Main Metabolite ◽  
Inorganic Arsenics

Methylation and Demethylation of Dimethylarsinic Acid in Rats Following Chronic Oral Exposure

1996 ◽  
Vol 10 (9) ◽  
pp. 741-745 ◽  
Author(s):  
Hua Chen ◽  
Kaoru Yoshida ◽  
Hideki Wanibuchi ◽  
Shoji Fukushima ◽  
Yoshinori Inoue ◽  
...  
Keyword(s):  
Oral Exposure ◽  
Dimethylarsinic Acid

scholarly journals Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Douglas Rossi Jesus ◽  
Lorena Neris Barbosa ◽  
Thiago Bruno Lima Prando ◽  
Leonardo Franco Martins ◽  
Francielli Gasparotto ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Toxicity Assessment ◽  
Cassava Starch ◽  
Pharmaceutical Products ◽  
The Body ◽  
Oral Exposure ◽  
Oral Toxicity ◽  
Starch Acetate ◽  
Target Organs ◽  
And Control

The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity in Wistar rats, indicating possible safety of this biofilm.

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