Nitric Oxide Mediates 17β-Estradiol-Stimulated Human and Rodent Osteoblast Proliferation and Differentiation

2000 ◽  
Vol 277 (3) ◽  
pp. 604-610 ◽  
Author(s):  
Meg C. O'Shaughnessy ◽  
Julia M. Polak ◽  
Faiza Afzal ◽  
Mika V.J. Hukkanen ◽  
Paul Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Osteoblast Proliferation ◽  
Proliferation And Differentiation ◽  
17Β Estradiol

Prevention of Fatty Streak Formation of 17β-Estradiol Is Not Mediated by the Production of Nitric Oxide in Apolipoprotein E– Deficient Mice

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 3048-3052 ◽  
Author(s):  
R. Elhage ◽  
F. Bayard ◽  
V. Richard ◽  
P. Holvoet ◽  
N. Duverger ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Apolipoprotein E ◽  
Fatty Streak ◽  
17Β Estradiol ◽  
Deficient Mice

scholarly journals Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tuo Deng ◽  
Wenwen Zhang ◽  
Yanling Zhang ◽  
Mengqi Zhang ◽  
Zhikun Huan ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Osteoblast Proliferation ◽  
Normal Thyroid ◽  
Normal Thyroid Function ◽  
Gene And Protein Expression ◽  
Proliferation And Differentiation ◽  
Stimulating Hormone

Abstract Background As the incidence of secretory osteoporosis has increased, bone loss, osteoporosis and their relationships with thyroid-stimulating hormone (TSH) have received increased attention. In this study, the role of TSH in bone metabolism and its possible underlying mechanisms were investigated. Methods We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and TSH and the bone mineral density (BMD) levels of 114 men with normal thyroid function. In addition, osteoblasts from rat calvarial samples were treated with different doses of TSH for different lengths of time. The related gene and protein expression levels were investigated. Results A comparison of the BMD between the high-level and low-level serum TSH groups showed that the TSH serum concentration was positively correlated with BMD. TSH at concentrations of 10 mU/mL and 100 mU/mL significantly increased the mRNA levels of ALP, COI1 and Runx2 compared with those of the control (P < 0.05, P < 0.01). Bone morphogenetic protein (BMP)2 activity was enhanced with both increased TSH concentration and increased time. The protein levels of Runx2 and osterix were increased in a dose-dependent manner. Conclusions The circulating concentrations of TSH and BMD were positively correlated with normal thyroid function in males. TSH promoted osteoblast proliferation and differentiation in rat primary osteoblasts.

Low intensity lasers differently induce primary human osteoblast proliferation and differentiation

2016 ◽  
Vol 163 ◽  
pp. 14-21 ◽  
Author(s):  
Flávia A. Oliveira ◽  
Adriana A. Matos ◽  
Mariana R. Santesso ◽  
Cintia K. Tokuhara ◽  
Aline L. Leite ◽  
...  
Keyword(s):  
Human Osteoblast ◽  
Osteoblast Proliferation ◽  
Low Intensity ◽  
Primary Human Osteoblast ◽  
Proliferation And Differentiation

scholarly journals Effect of rat brain tissue extracts on osteoblast proliferation and differentiation

2011 ◽  
Vol 36 (4) ◽  
pp. 887-893
Author(s):  
Gang-Yong Huang ◽  
Xin Ma ◽  
Xin-Lei Xia ◽  
Jian-Yuan Jiang ◽  
Wei-Fang Jin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Osteoblast Proliferation ◽  
Tissue Extracts ◽  
Proliferation And Differentiation ◽  
Rat Brain Tissue

LncRNA GHET1 promotes osteoblast proliferation and differentiation by inhibiting PTEN

2019 ◽  
Author(s):  
Deheng Li ◽  
Liangdong Li ◽  
Xin Chen ◽  
Yang Gao ◽  
Yiqun Cao ◽  
...  
Keyword(s):  
Osteoblast Proliferation ◽  
Proliferation And Differentiation
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