Molecular to pharmacologic control of osteoblast proliferation and differentiation

1994 ◽  
Vol 55 (3) ◽  
pp. 310-320 ◽  
Author(s):  
Suresh R. Siddhanti ◽  
L. Darryl Quarles
Keyword(s):  
Osteoblast Proliferation ◽  
Proliferation And Differentiation

scholarly journals Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tuo Deng ◽  
Wenwen Zhang ◽  
Yanling Zhang ◽  
Mengqi Zhang ◽  
Zhikun Huan ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Mrna Levels ◽  
Dependent Manner ◽  
Osteoblast Proliferation ◽  
Normal Thyroid ◽  
Normal Thyroid Function ◽  
Gene And Protein Expression ◽  
Proliferation And Differentiation ◽  
Stimulating Hormone

Abstract Background As the incidence of secretory osteoporosis has increased, bone loss, osteoporosis and their relationships with thyroid-stimulating hormone (TSH) have received increased attention. In this study, the role of TSH in bone metabolism and its possible underlying mechanisms were investigated. Methods We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and TSH and the bone mineral density (BMD) levels of 114 men with normal thyroid function. In addition, osteoblasts from rat calvarial samples were treated with different doses of TSH for different lengths of time. The related gene and protein expression levels were investigated. Results A comparison of the BMD between the high-level and low-level serum TSH groups showed that the TSH serum concentration was positively correlated with BMD. TSH at concentrations of 10 mU/mL and 100 mU/mL significantly increased the mRNA levels of ALP, COI1 and Runx2 compared with those of the control (P < 0.05, P < 0.01). Bone morphogenetic protein (BMP)2 activity was enhanced with both increased TSH concentration and increased time. The protein levels of Runx2 and osterix were increased in a dose-dependent manner. Conclusions The circulating concentrations of TSH and BMD were positively correlated with normal thyroid function in males. TSH promoted osteoblast proliferation and differentiation in rat primary osteoblasts.

Nitric Oxide Mediates 17β-Estradiol-Stimulated Human and Rodent Osteoblast Proliferation and Differentiation

2000 ◽  
Vol 277 (3) ◽  
pp. 604-610 ◽  
Author(s):  
Meg C. O'Shaughnessy ◽  
Julia M. Polak ◽  
Faiza Afzal ◽  
Mika V.J. Hukkanen ◽  
Paul Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Osteoblast Proliferation ◽  
Proliferation And Differentiation ◽  
17Β Estradiol

Low intensity lasers differently induce primary human osteoblast proliferation and differentiation

2016 ◽  
Vol 163 ◽  
pp. 14-21 ◽  
Author(s):  
Flávia A. Oliveira ◽  
Adriana A. Matos ◽  
Mariana R. Santesso ◽  
Cintia K. Tokuhara ◽  
Aline L. Leite ◽  
...  
Keyword(s):  
Human Osteoblast ◽  
Osteoblast Proliferation ◽  
Low Intensity ◽  
Primary Human Osteoblast ◽  
Proliferation And Differentiation

scholarly journals Effect of rat brain tissue extracts on osteoblast proliferation and differentiation

2011 ◽  
Vol 36 (4) ◽  
pp. 887-893
Author(s):  
Gang-Yong Huang ◽  
Xin Ma ◽  
Xin-Lei Xia ◽  
Jian-Yuan Jiang ◽  
Wei-Fang Jin ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Osteoblast Proliferation ◽  
Tissue Extracts ◽  
Proliferation And Differentiation ◽  
Rat Brain Tissue

LncRNA GHET1 promotes osteoblast proliferation and differentiation by inhibiting PTEN

2019 ◽  
Author(s):  
Deheng Li ◽  
Liangdong Li ◽  
Xin Chen ◽  
Yang Gao ◽  
Yiqun Cao ◽  
...  
Keyword(s):  
Osteoblast Proliferation ◽  
Proliferation And Differentiation

The Effects of Exercise Serum From Prepubertal Girls and Women on In Vitro Myoblast and Osteoblast Proliferation and Differentiation

2021 ◽  
Vol 33 (2) ◽  
pp. 82-89
Author(s):  
Yasmeen Mezil ◽  
Joyce Obeid ◽  
Inna Ushcatz ◽  
Sandeep Raha ◽  
Brian W. Timmons
Keyword(s):  
Moderate Intensity ◽  
Osteoblast Proliferation ◽  
Moderate Intensity Exercise ◽  
Acute Bout ◽  
Myotube Formation ◽  
Proliferation And Differentiation ◽  
Proliferation In Vitro ◽  
Prepubertal Girls ◽  
Time Point

Purpose: In girls and women, the authors studied the effects of an acute bout of low-impact, moderate-intensity exercise serum on myoblast and osteoblast proliferation in vitro. Methods: A total of 12 pre/early pubertal girls (8–10 y old) and 12 women (20–30 y old) cycled at 60% VO2max for 1 hour followed by 1-hour recovery. Blood samples were collected at rest, mid-exercise, end of exercise, mid-recovery, and end of recovery. C2C12 myoblasts and MC3T3E1 osteoblasts were incubated with serum from each time point for 1 hour, then monitored for 24 hours (myoblasts) or 36 hours (osteoblasts) to examine proliferation. Cells were also monitored for 6 days (myoblasts) to examine myotube formation and 21 days (osteoblasts) to examine mineralization. Results: Exercise did not affect myoblast or osteoblast proliferation. Girls exhibited lower cell proliferation relative to women at end of exercise (osteoblasts, P = .041; myoblasts, P = .029) and mid-recovery (osteoblasts, P = .010). Mineralization was lower at end of recovery relative to rest (P = .014) in both girls and women. Myotube formation was not affected by exercise or group. Conclusion: The systemic environment following one acute bout of low-impact moderate-intensity exercise in girls and women does not elicit osteoblast or myoblast activity in vitro. Differences in myoblast and osteoblast proliferation between girls and women may be influenced by maturation.

Biomimetic Mineralization and Bioactivity of Phosphorylated Chitosan

2005 ◽  
Vol 288-289 ◽  
pp. 429-432 ◽  
Author(s):  
Zhi Qing Chen ◽  
Quan Li Li ◽  
Quan Zen ◽  
Gang Li ◽  
Hao Bin Jiang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Crystal Nucleation ◽  
Osteoblast Proliferation ◽  
Biomimetic Mineralization ◽  
P Content ◽  
Proliferation And Differentiation ◽  
Nucleation Growth

Phosphorylated chitosans were synthesized as templates to manipulate hydroxyapatite (HA) crystal nucleation, growth and microstructure. Two kinds of insoluble phosphorylated chitosan were soaked in saturated Ca(OH)2 solution for 4 d and in 1.5× SBF (simulated body fluid) solutions for 14 d at 37 °C for biomimetic mineralization. A lower [P]-content of phosphorylated chitosan promoted greater mineralization than higher [P]-content. Phosphorylated chitosan inhibited osteoblast proliferation and differentiation in vitro, while calcium phosphate phosphorylated chitosan composites did not.

Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β-catenin pathway

2018 ◽  
Vol 99 ◽  
pp. 319-324 ◽  
Author(s):  
Kejia Li ◽  
Xiaochao Zhang ◽  
Bo He ◽  
Renhua Yang ◽  
Yue Zhang ◽  
...  
Keyword(s):  
Osteoblast Proliferation ◽  
Proliferation And Differentiation
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