Characterization of the Advanced Glycation End-Product Receptor Complex in Human Vascular Endothelial Cells

1999 ◽  
Vol 256 (3) ◽  
pp. 549-556 ◽  
Author(s):  
Alan W. Stitt ◽  
Cijang He ◽  
Helen Vlassara
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Receptor Complex ◽  
Advanced Glycation ◽  
Advanced Glycation End Product

scholarly journals RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jun-ichi Takino ◽  
Takuma Sato ◽  
Takumi Kanetaka ◽  
Kasumi Okihara ◽  
Kentaro Nagamine ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Permeability ◽  
Advanced Glycation End Products ◽  
Protective Factor ◽  
Vascular Endothelial Cells ◽  
Enzymatic Reaction ◽  
Vascular Endothelial ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

AbstractAdvanced glycation end-products (AGEs) are formed by the non-enzymatic reaction of sugars and proteins. Among the AGEs, glyceraldehyde-derived toxic AGEs (TAGE) are associated with various diseases, including diabetic complications such as diabetic retinopathy (DR). The risk of developing DR is strongly associated with poor glycemic control, which causes AGE accumulation and increases AGE-induced vascular permeability. We previously reported that Ras guanyl nucleotide releasing protein 2 (RasGRP2), which activates small G proteins, may play an essential role in the cell response to toxicity when exposed to various factors. However, it is not known whether RasGRP2 prevents the adverse effects of TAGE in vascular endothelial cells. This study observed that TAGE enhanced vascular permeability by disrupting adherens junctions and tight junctions via complex signaling, such as ROS and non-ROS pathways. In particular, RasGRP2 protected adherens junction disruption, thereby suppressing vascular hyper-permeability. These results indicate that RasGRP2 is an essential protective factor of vascular permeability and may help develop novel therapeutic strategies for AGE-induced DR.

Molecular cloning and characterization of antigens expressed on rat tumor vascular endothelial cells

2000 ◽  
Vol 86 (6) ◽  
pp. 799-805 ◽  
Author(s):  
Kenji Taniguchi ◽  
Naoki Harada ◽  
Iwao Ohizumi ◽  
Michiko Kinoshita ◽  
Yasuo Tsutsumi ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Molecular Cloning ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Rat Tumor

Isolation and characterization of vascular endothelial cells derived from fetal tooth buds of miniature swine

2013 ◽  
Vol 49 (3) ◽  
pp. 189-195 ◽  
Author(s):  
Masanori Nasu ◽  
Taka Nakahara ◽  
Noriko Tominaga ◽  
Yuichi Tamaki ◽  
Yoshiaki Ide ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Miniature Swine ◽  
Isolation And Characterization ◽  
Tooth Buds

Characterization of endothelin secretion by vascular endothelial cells

1990 ◽  
Vol 167 (1) ◽  
pp. 294-300 ◽  
Author(s):  
Terry D. Hexum ◽  
Carl Hoeger ◽  
Jean E. Rivier ◽  
Andrew Baird ◽  
Marvin R. Brown
Keyword(s):  
Endothelial Cells ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial
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