Cloning and Characterization of BAP3 (BAI-Associated Protein 3), a C2 Domain-Containing Protein That Interacts with BAI1

1998 ◽  
Vol 251 (1) ◽  
pp. 158-165 ◽  
Author(s):  
Takayuki Shiratsuchi ◽  
Katsutoshi Oda ◽  
Hiroyuki Nishimori ◽  
Mikio Suzuki ◽  
Eiichi Takahashi ◽  
...  
Keyword(s):  
C2 Domain

scholarly journals Characterization of Multiple C2 Domain and Transmembrane Region Proteins in Arabidopsis

2017 ◽  
Vol 176 (3) ◽  
pp. 2119-2132 ◽  
Author(s):  
Lu Liu ◽  
Chunying Li ◽  
Zhe Liang ◽  
Hao Yu
Keyword(s):  
C2 Domain ◽  
Transmembrane Region

Characterization of the Membrane Binding Mode of the C2 Domain of PKCε†

Biochemistry ◽  
2003 ◽  
Vol 42 (40) ◽  
pp. 11661-11668 ◽  
Author(s):  
Senena Corbalán-Garcia ◽  
Susana Sánchez-Carrillo ◽  
Josefa García-García ◽  
Juan C. Gómez-Fernández
Keyword(s):  
Membrane Binding ◽  
Binding Mode ◽  
C2 Domain

Characterization of the optimized C2 domain of protein G: finding its additional chicken IgY-binding ability

2013 ◽  
Vol 35 (9) ◽  
pp. 1441-1447 ◽  
Author(s):  
Yongsheng Cao ◽  
Di Li ◽  
Chong Cao ◽  
Mingchun Gao ◽  
Runxiang Zhang ◽  
...  
Keyword(s):  
Protein G ◽  
C2 Domain ◽  
Binding Ability

Molecular characterization of a pepper C2 domain-containing SRC2 protein implicated in resistance against host and non-host pathogens and abiotic stresses

Planta ◽  
2008 ◽  
Vol 227 (5) ◽  
pp. 1169-1179 ◽  
Author(s):  
Young-Cheol Kim ◽  
Soo-Yong Kim ◽  
Doil Choi ◽  
Choong-Min Ryu ◽  
Jeong Mee Park
Keyword(s):  
Molecular Characterization ◽  
Abiotic Stresses ◽  
C2 Domain

scholarly journals Structural characterization of the PtdIns(4,5)P 2 ‐PKCα‐C2 domain interaction

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Senena Corbalan‐Garcia ◽  
Marta Guerrero‐Valero ◽  
Cristina Ferrer‐Orta ◽  
Jordi Querol‐Audi ◽  
Consuelo Marin‐Vicente ◽  
...  
Keyword(s):  
Structural Characterization ◽  
C2 Domain ◽  
Domain Interaction

Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase C2 domain

2020 ◽  
Vol 148 ◽  
pp. 180-192
Author(s):  
Mohd Sabri Pak Dek ◽  
Priya Padmanabhan ◽  
Krishnaraj Tiwari ◽  
James F. Todd ◽  
Gopinadhan Paliyath
Keyword(s):  
Solanum Lycopersicum ◽  
Functional Characterization ◽  
C2 Domain ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

Cloning and Characterization of a Novel Class II Phosphoinositide 3-Kinase Containing C2 Domain

1998 ◽  
Vol 244 (2) ◽  
pp. 531-539 ◽  
Author(s):  
Hiroyuki Misawa ◽  
Motoaki Ohtsubo ◽  
Neal G. Copeland ◽  
Debra J. Gilbert ◽  
Nancy A. Jenkins ◽  
...  
Keyword(s):  
Class Ii ◽  
C2 Domain ◽  
Phosphoinositide 3 Kinase

scholarly journals Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

1997 ◽  
Vol 326 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Jan DOMIN ◽  
Françoise PAGES ◽  
Stefano VOLINIA ◽  
Susan E. RITTENHOUSE ◽  
Marketa J. ZVELEBIL ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Biochemical Analysis ◽  
Cellular Responses ◽  
C2 Domain ◽  
Substrate Specificities ◽  
Sequence Heterogeneity ◽  
Phosphoinositide 3 Kinase ◽  
Lipid Substrate ◽  
K Activity

The generation of phosphatidylinositide 3-phosphates has been observed in a variety of cellular responses. The enzymes that mediate synthesis are the phosphoinositide 3-kinases (PI3-Ks) that form a family of structurally diverse enzymes with distinct substrate specificities. In this paper, we describe the cloning of a novel human PI3-K, namely PI3-K-C2α, which contains a C-terminal C2 domain. This enzyme can be assigned to the class II PI3-Ks, which was defined by characterization of the Drosophila 68D enzyme and includes the recently described murine enzymes m-cpk and p170. Despite the overall similarity in the amino acid sequence of the murine and human enzymes, which suggests that they are encoded by closely related genes, these molecules show marked sequence heterogeneity at their N-termini. Biochemical analysis of recombinant PI3-K-C2α demonstrates a restricted lipid substrate specificity. As reported for other members of this class, the enzyme only phosphorylates PtdIns and PtdIns4P when the lipids are presented alone. However, when lipids were presented together with phosphatidylserine acting as a carrier, phosphorylation of PtdIns(4,5)P2 was also observed. The catalytic activity of PI3-K-C2α is refractory to concentrations of wortmannin and LY294002 which inhibit the PI3-K activity of other family members. The comparative insensitivity of PI3-K-C2α to these inhibitors suggests that their use should be re-evaluated in the study of PI3-Ks.

Characterization of a wheat C2 domain protein encoding gene regulated by stripe rust and abiotic stresses

2013 ◽  
Vol 57 (4) ◽  
pp. 701-710 ◽  
Author(s):  
G. Zhang ◽  
Y. F. Sun ◽  
Y. M. Li ◽  
Y. L. Dong ◽  
X. L. Huang ◽  
...  
Keyword(s):  
Stripe Rust ◽  
Abiotic Stresses ◽  
C2 Domain ◽  
Protein Encoding ◽  
Domain Protein ◽  
Encoding Gene
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