Functional Effects of FGF-13 on Human Lung Fibroblasts, Dermal Microvascular Endothelial Cells, and Aortic Smooth Muscle Cells

1998 ◽  
Vol 251 (2) ◽  
pp. 667
Author(s):  
Kam H. Leung ◽  
Vani Pippalla ◽  
Anne Kreutter ◽  
Mary Chandler
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Human Lung ◽  
Muscle Cells ◽  
Lung Fibroblasts ◽  
Microvascular Endothelial Cells ◽  
Human Lung Fibroblasts ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

scholarly journals Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Manal Fardoun ◽  
Tuqa Al-Shehabi ◽  
Ahmed El-Yazbi ◽  
Khodr Issa ◽  
Fouad Zouein ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Matrix Metalloproteases ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Ziziphus Nummularia

Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and vascular smooth muscle cells (VSMCs). Despite significant advances, current treatments for atherosclerosis remain insufficient, prompting the search for alternative modalities, including herbal medicine. Ziziphus nummularia is an herb commonly used in the amelioration of symptoms associated with many health conditions such as cold, diarrhea, cancer, and diabetes. However, its effect on the inflammation-induced behavior of VSMCs remains unknown. In this study, we sought to determine the effect of the ethanolic extract of Z. nummularia (ZNE) on TNF-α-induced phenotypic changes of human aortic smooth muscle cells (HASMCs). The treatment of HASMCs with ZNE decreased cell proliferation, adhesion to fibronectin, migration, and invasion. ZNE treatment also caused a concentration- and time-dependent reduction in the TNF-α-induced expression of matrix metalloproteases MMP-2 and MMP-9, NF-κB, and cell adhesion molecules ICAM-1 and VCAM-1. Furthermore, ZNE decreased the adhesion of THP-1 monocytes to HASMCs and endothelial cells in a concentration-dependent manner. These data provide evidence for the anti-inflammatory effect of Ziziphus nummularia, along with potential implications for its use as an agent that could ameliorate inflammation-induced atherogenic phenotype of VSMCs in atherosclerosis.

scholarly journals Human Aortic Smooth Muscle Cells Promote Arteriole Formation by Coengrafted Endothelial Cells

2009 ◽  
Vol 15 (1) ◽  
pp. 165-173 ◽  
Author(s):  
Benjamin R. Shepherd ◽  
Steven M. Jay ◽  
W. Mark Saltzman ◽  
George Tellides ◽  
Jordan S. Pober
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle
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