Intracavitary Liposome-Mediated p53 Gene Transfer into Glioblastoma with Endogenous Wild-Type p53in VivoResults in Tumor Suppression and Long-Term Survival

1997 ◽  
Vol 233 (2) ◽  
pp. 359-364 ◽  
Author(s):  
Michael Hsiao ◽  
Victor Tse ◽  
Jason Carmel ◽  
Yali Tsai ◽  
Philip L. Felgner ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Tumor Suppression ◽  
P53 Gene ◽  
Wild Type ◽  
Term Survival ◽  
Long Term Survival

Adenovirus-mediated OX40Ig gene transfer induces long-term survival of orthotopic liver allograft in rats

2018 ◽  
Vol 48 ◽  
pp. 32-38 ◽  
Author(s):  
Zhi-hong Chen ◽  
Chao Wang ◽  
Fa-xing Wei ◽  
Bin-bin Xu ◽  
Jun Liu ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Liver Allograft ◽  
Term Survival ◽  
Long Term Survival

Long-term survival in primary glioblastoma revisited: The contribution of isocitrate dehydrogenase mutations.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 2027-2027
Author(s):  
Michael Weller ◽  
Bettina Hentschel ◽  
Matthias Simon ◽  
Manfred Westphal ◽  
Gabriele Schackert ◽  
...  
Keyword(s):  
Promoter Methylation ◽  
Mgmt Promoter Methylation ◽  
Molecular Characteristics ◽  
Wild Type ◽  
Who Grade ◽  
Term Survival ◽  
Long Term Survival ◽  
Tp53 Mutations ◽  
Mgmt Promoter

2027 Background: The determinants of long-term survival in glioblastoma have remained largely obscure. Isocitrate dehydrogenase (IDH) 1 or 2 mutations are common in WHO grade 2/3 gliomas, but rare in primary glioblastomas, and associated with longer survival. Methods: We compared clinical and molecular characteristics of 69 patients with centrally confirmed glioblastoma and survival > 36 months (LTS-36), including 33 patients surviving > 60 months (LTS-60), with 259 patients surviving < 36 months. MGMT promoter methylation, 1p/19q codeletions, EGFR amplification, TP53 mutations and IDH1/2mutations were determined by standard techniques. Results: The rate of IDH1/2 mutations in LTS-36 patients was 34% (23/67 patients) as opposed to 4.3% in controls (11/257 patients). Long-term survivors with IDH1/2 -mutant glioblastomas were younger, had almost no EGFR amplifications, but exhibited more often 1p/19q codeletions and TP53 mutations than LTS patients with IDH1/2 wild-type glioblastomas. Among LTS-36 patients, wild-type TP53 status, MGMT promoter methylation, and absence of EGFR amplification, but not IDH1/2 mutation, were associated with prolonged survival. Among 11 patients with IDH1/2-mutant glioblastomas without long-term survival, the only difference to IDH1/2-mutant long-term survivors was less frequent MGMT promoter methylation. Compared with LTS-36 patients, LTS-60 patients had been treated initially with radiotherapy alone and had TP53 mutations less frequently. Conclusions: IDH1/2 mutations define a subgroup of tumors of LTS patients that exhibit molecular characteristics of WHO grade 2/3 gliomas and secondary glioblastomas. Determinants of LTS with IDH1/2 wild-type glioblastomas, which exhibit typical molecular features of primary glioblastomas, beyond MGMT promoter methylation, remain to be identified.

scholarly journals The Stringent Response of Mycobacterium tuberculosis Is Required for Long-Term Survival

2000 ◽  
Vol 182 (17) ◽  
pp. 4889-4898 ◽  
Author(s):  
Todd P. Primm ◽  
Susan J. Andersen ◽  
Valerie Mizrahi ◽  
David Avarbock ◽  
Harvey Rubin ◽  
...  
Keyword(s):  
Growth Rate ◽  
Mycobacterium Tuberculosis ◽  
Stringent Response ◽  
Wild Type ◽  
Liquid Media ◽  
Term Survival ◽  
Long Term Survival ◽  
Starvation Conditions

ABSTRACT The stringent response utilizes hyperphosphorylated guanine [(p)ppGpp] as a signaling molecule to control bacterial gene expression involved in long-term survival under starvation conditions. In gram-negative bacteria, (p)ppGpp is produced by the activity of the related RelA and SpoT proteins. Mycobacterium tuberculosis contains a single homolog of these proteins (RelMtb) and responds to nutrient starvation by producing (p)ppGpp. A relMtb knockout strain was constructed in a virulent strain of M. tuberculosis, H37Rv, by allelic replacement. The relMtb mutant displayed a significantly slower aerobic growth rate than the wild type in synthetic liquid media, whether rich or minimal. The growth rate of the wild type was equivalent to that of the mutant when citrate or phospholipid was employed as the sole carbon source. These two organisms also showed identical growth rates within a human macrophage-like cell line. These results suggest that the in vivo carbon source does not represent a stressful condition for the bacilli, since it appears to be utilized in a similar RelMtb-independent manner. In vitro growth in liquid media represents a condition that benefits from RelMtb-mediated adaptation. Long-term survival of therelMtb mutant during in vitro starvation or nutrient run out in normal media was significantly impaired compared to that in the wild type. In addition, the mutant was significantly less able to survive extended anerobic incubation than the wild-type virulent organism. Thus, the RelMtb protein is required for long-term survival of pathogenic mycobacteria under starvation conditions.

Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression

1994 ◽  
Vol 5 (8) ◽  
pp. 465-472 ◽  
Author(s):  
J. R. Dorin ◽  
B. J. Stevenson ◽  
S. Fleming ◽  
E. W. F. W. Alton ◽  
P. Dickinson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cystic Fibrosis ◽  
Mutant Mouse ◽  
Cftr Gene ◽  
Wild Type ◽  
Term Survival ◽  
Long Term Survival ◽  
Low Level ◽  
Exon 10

scholarly journals Case Report: Long-Term Survival in Patient with Cirrhosis of the Liver and Colon Cancer K-ras Wild-Type

2014 ◽  
Vol 03 (06) ◽  
pp. 373-377
Author(s):  
Emiddio Barletta ◽  
Lucia Cannella ◽  
Vincenza Tinessa ◽  
Domenico Germano ◽  
Bruno Daniele
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Cirrhosis Of The Liver ◽  
Wild Type ◽  
Term Survival ◽  
Long Term Survival
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