Human Immunodeficiency Virus Type-1 TAT Enhances Interleukin-2 Promoter Activity Through Synergism with Phorbol Ester and Calcium-Mediated Activation of the NF-AT cis-Regulatory Motif

1994 ◽  
Vol 205 (1) ◽  
pp. 467-474 ◽  
Author(s):  
A. Vacca ◽  
M. Farina ◽  
M. Maroder ◽  
E. Alesse ◽  
I. Screpanti ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Phorbol Ester ◽  
Promoter Activity ◽  
Interleukin 2 ◽  
Regulatory Motif ◽  
Immunodeficiency Virus

scholarly journals Human Immunodeficiency Virus Type 1-Specific Immune Responses in Primates upon Sequential Immunization with Adenoviral Vaccine Carriers of Human and Simian Serotypes

2004 ◽  
Vol 78 (14) ◽  
pp. 7392-7399 ◽  
Author(s):  
A. Reyes-Sandoval ◽  
J. C. Fitzgerald ◽  
R. Grant ◽  
S. Roy ◽  
Z. Q. Xiang ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
Immune Responses ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Interleukin 2 ◽  
Cell Subset ◽  
Immunodeficiency Virus ◽  
Adenoviral Vaccine

ABSTRACT Two triple immunization vaccine regimens with adenoviral vectors with E1 deleted expressing Gag of human immunodeficiency virus type 1 were tested for induction of T- and B-cell-mediated-immune responses in mice and in nonhuman primates. The vaccine carriers were derived from distinct serotypes of human and simian adenoviruses that fail to elicit cross-neutralizing antibodies expected to dampen the effect of booster immunizations. Both triple immunization regimens induced unprecedented frequencies of gamma interferon-producing CD8+ T cells to Gag in mice and monkeys that remained remarkably stable over time. In addition, monkeys developed Gag-specific interleukin-2-secreting T cells, presumably belonging to the CD4+ T-cell subset, and antibodies to both Gag and the adenoviral vaccine carriers.

Sign in / Sign up

Export Citation Format

Share Document