Tight Hormonal Control of PRP Gene Expression in Endocrine Pancreatic Cells

1994 ◽  
Vol 201 (3) ◽  
pp. 1220-1226 ◽  
Author(s):  
F. Atouf ◽  
R. Scharfmann ◽  
C. Lasmezas ◽  
P. Czernichow
Keyword(s):  
Gene Expression ◽  
Hormonal Control ◽  
Pancreatic Cells ◽  
Prp Gene ◽  
Endocrine Pancreatic Cells

scholarly journals Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse

Diabetologia ◽  
2009 ◽  
Vol 52 (4) ◽  
pp. 645-652 ◽  
Author(s):  
R. Kikugawa ◽  
H. Katsuta ◽  
T. Akashi ◽  
S. Yatoh ◽  
G. C. Weir ◽  
...  
Keyword(s):  
Pancreatic Cells ◽  
Endocrine Pancreatic Cells

HORMONAL CONTROL OF GENE EXPRESSION.

1988 ◽  
Vol 29 (3) ◽  
pp. 337-348 ◽  
Author(s):  
J. A. FRANKLYN ◽  
M. C. SHEPPARD
Keyword(s):  
Gene Expression ◽  
Hormonal Control ◽  
Control Of Gene Expression

Pancreatic vasopressin V1b receptors: characterization in In-R1-G9 cells and localization in human pancreas

2003 ◽  
Vol 285 (3) ◽  
pp. E566-E576 ◽  
Author(s):  
Viviane Folny ◽  
Danielle Raufaste ◽  
Ludovit Lukovic ◽  
Brigitte Pouzet ◽  
Pierrick Rochard ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Glucagon Secretion ◽  
Hormonal Control ◽  
Human Pancreas ◽  
Single Population ◽  
Pancreatic Cell ◽  
Functional Studies ◽  
Mediated Effects ◽  
Pancreatic Cells ◽  
Intracellular Ca

Vasopressin (AVP) receptors present in In-R1-G9 cells, a hamster glucagon-secreting α-pancreatic cell line, were characterized using SSR-149415, a selective nonpeptide V1b receptor antagonist, and reference AVP compounds. Binding experiments, using [3H]AVP as a ligand, identified a single population of high-affinity binding sites. SSR-149415 competitively inhibited this binding and exhibited nanomolar and stereospecific affinity for these sites. The affinity of various AVP/oxytocin ligands confirmed a V1b binding profile. In functional studies, AVP was a potent stimulant in inducing intracellular Ca2+ increase, glucagon secretion, and cell proliferation. These effects were fully antagonized by SSR-149415 with a nanomolar potency, whereas its diasteroisomer as well as two selective V1a and V2 receptor antagonists were much less potent. Additionally, the order of potency of AVP agonists and antagonists was in agreement with V1b-mediated effects. By RT-PCR, we confirmed the presence of V1b receptor mRNA in both In-R1-G9 cells and in human pancreas. The distribution pattern of V1b receptors investigated in human pancreas by immunohistochemistry showed strong labeling in islets of Langerhans, and colocalization studies indicated that this receptor was expressed in α-glucagon, β-insulin, and somatostatin pancreatic cells. Thus, in In-R1-G9 cells, AVP mediates intracellular Ca2+ increase, glucagon secretion, and cell proliferation by activating V1b receptors, and these effects are potently antagonized by SSR-149415. Moreover, the presence of V1b receptors also found in human Langerhans islets could suggest hormonal control of AVP in human pancreas.

scholarly journals Foxa2 Controls Pdx1 Gene Expression in Pancreatic  -Cells In Vivo

Diabetes ◽  
2002 ◽  
Vol 51 (8) ◽  
pp. 2546-2551 ◽  
Author(s):  
C. S. Lee ◽  
N. J. Sund ◽  
M. Z. Vatamaniuk ◽  
F. M. Matschinsky ◽  
D. A. Stoffers ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cells

Culture of endocrine pancreatic cells in protein-free, chemically defined media

1990 ◽  
Vol 26 (10) ◽  
pp. 1004-1010 ◽  
Author(s):  
Fabienne Kinard ◽  
Lieve Clercq ◽  
Brigitte Billen ◽  
Brigitte Amory ◽  
Jules-Joseph Hoet ◽  
...  
Keyword(s):  
Chemically Defined Media ◽  
Pancreatic Cells ◽  
Defined Media ◽  
Endocrine Pancreatic Cells

scholarly journals Delegating Sex: Differential Gene Expression in Stolonizing Syllids Uncovers the Hormonal Control of Reproduction

2018 ◽  
Vol 11 (1) ◽  
pp. 295-318 ◽  
Author(s):  
Patricia Álvarez-Campos ◽  
Nathan J Kenny ◽  
Aida Verdes ◽  
Rosa Fernández ◽  
Marta Novo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Differential Gene Expression ◽  
Hormonal Control ◽  
Differential Gene

scholarly journals Mechanisms of Enhancer-mediated Hormonal Control of Vitamin D Receptor Gene Expression in Target Cells

2015 ◽  
Vol 290 (51) ◽  
pp. 30573-30586 ◽  
Author(s):  
Seong Min Lee ◽  
Mark B. Meyer ◽  
Nancy A. Benkusky ◽  
Charles A. O'Brien ◽  
J. Wesley Pike
Keyword(s):  
Gene Expression ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Hormonal Control ◽  
Target Cells ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Expression

scholarly journals Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic  -Cells

Diabetes ◽  
2009 ◽  
Vol 58 (9) ◽  
pp. 2048-2058 ◽  
Author(s):  
G. Fontes ◽  
M. Semache ◽  
D. K. Hagman ◽  
C. Tremblay ◽  
R. Shah ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Gene ◽  
Pancreatic Cells ◽  
Insulin Gene Expression
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