Decrease of Red Cell Membrane Fluidity and -SH Groups Due to Hyperglycemic Conditions Is Counteracted by α-Lipoic Acid1

1995 ◽  
Vol 324 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Michael Hofmann ◽  
Peter Mainka ◽  
Hans Tritschler ◽  
Jürgen Fuchs ◽  
Guido Zimmer
Keyword(s):  
Cell Membrane ◽  
Membrane Fluidity ◽  
Red Cell ◽  
Red Cell Membrane ◽  
Sh Groups ◽  
Cell Membrane Fluidity

A compensatory mechanism improving red cell membrane fluidity in hemodialysed patients

1990 ◽  
Vol 190 (1-2) ◽  
pp. 57-66 ◽  
Author(s):  
Evelyne Peuchant ◽  
Claude Motta ◽  
Christine Salles ◽  
Michel Clerc
Keyword(s):  
Cell Membrane ◽  
Membrane Fluidity ◽  
Compensatory Mechanism ◽  
Red Cell ◽  
Red Cell Membrane ◽  
Cell Membrane Fluidity

Red cell membrane fluidity in combined hyperlipidaemia

1995 ◽  
Vol 115 ◽  
pp. S108
Author(s):  
S.I. Muzulu ◽  
R.I. Norman ◽  
R.F. Bing
Keyword(s):  
Cell Membrane ◽  
Membrane Fluidity ◽  
Red Cell ◽  
Red Cell Membrane ◽  
Cell Membrane Fluidity

scholarly journals Lipid analyses and fluidity studies by electron spin resonance of red cell membranes in hereditary high red cell membrane phosphatidylcholine hemolytic anemia

Blood ◽  
1984 ◽  
Vol 64 (5) ◽  
pp. 1129-1134 ◽  
Author(s):  
Y Yawata ◽  
T Sugihara ◽  
M Mori ◽  
S Nakashima ◽  
Y Nozawa
Keyword(s):  
Electron Spin Resonance ◽  
Cell Membrane ◽  
Membrane Fluidity ◽  
Hemolytic Anemia ◽  
Electron Spin ◽  
Order Parameter ◽  
Red Cells ◽  
Red Cell ◽  
Red Cell Membrane ◽  
Spin Resonance

Abstract Membrane lipid analyses and electron spin resonance (ESR) studies of membrane fluidity were carried out on the red cells of a Japanese patient with hereditary high red cell membrane phosphatidylcholine hemolytic anemia (HPCHA). Increased amounts of phosphatidylcholine (PC) and cholesterol were found in the membrane lipids of the affected patient, despite normal plasma lipids. The order parameter of cholesterol-free pure phospholipid liposomes prepared from this patient's red cells was decreased, apparently because of the increased PC. In contrast, the order parameter of the total red cell lipid liposomes (containing free cholesterol) was essentially normal. The overall fluidity of the intact red cells was determined by ESR with a spin probe, 5-SAL. Again, the order parameters were normal in the intact red cells of the patient with HPCHA. This suggests that the concomitant increase of membrane cholesterol and phosphatidylcholine serves to maintain normal membrane fluidity in the HPCHA red cells.

scholarly journals Lipid analyses and fluidity studies by electron spin resonance of red cell membranes in hereditary high red cell membrane phosphatidylcholine hemolytic anemia

Blood ◽  
1984 ◽  
Vol 64 (5) ◽  
pp. 1129-1134
Author(s):  
Y Yawata ◽  
T Sugihara ◽  
M Mori ◽  
S Nakashima ◽  
Y Nozawa
Keyword(s):  
Electron Spin Resonance ◽  
Cell Membrane ◽  
Membrane Fluidity ◽  
Hemolytic Anemia ◽  
Electron Spin ◽  
Order Parameter ◽  
Red Cells ◽  
Red Cell ◽  
Red Cell Membrane ◽  
Spin Resonance

Membrane lipid analyses and electron spin resonance (ESR) studies of membrane fluidity were carried out on the red cells of a Japanese patient with hereditary high red cell membrane phosphatidylcholine hemolytic anemia (HPCHA). Increased amounts of phosphatidylcholine (PC) and cholesterol were found in the membrane lipids of the affected patient, despite normal plasma lipids. The order parameter of cholesterol-free pure phospholipid liposomes prepared from this patient's red cells was decreased, apparently because of the increased PC. In contrast, the order parameter of the total red cell lipid liposomes (containing free cholesterol) was essentially normal. The overall fluidity of the intact red cells was determined by ESR with a spin probe, 5-SAL. Again, the order parameters were normal in the intact red cells of the patient with HPCHA. This suggests that the concomitant increase of membrane cholesterol and phosphatidylcholine serves to maintain normal membrane fluidity in the HPCHA red cells.

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