scholarly journals Endotoxin contamination of engineered nanomaterials: Overcoming the hurdles associated with endotoxin testing

2021 ◽  
Author(s):  
Gary Hannon ◽  
Adriele Prina‐Mello
Keyword(s):  
Engineered Nanomaterials ◽  
Endotoxin Contamination

Endotoxin contamination of engineered nanomaterials

2010 ◽  
Vol 4 (1) ◽  
pp. 73-83 ◽  
Author(s):  
R. Keith Esch ◽  
Li Han ◽  
Karin K. Foarde ◽  
David S. Ensor
Keyword(s):  
Engineered Nanomaterials ◽  
Endotoxin Contamination

Evaluation of EndoTrap® blue for removing endotoxin contamination from Echinacea extracts

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
S Gusenleitner ◽  
K Woelkart ◽  
S Barth ◽  
R Bauer
Keyword(s):  
Endotoxin Contamination

Toxicity Evaluation of Engineered Nanomaterials: Risk Evaluation Tools (Phase 3 Studies)

2012 ◽  
Author(s):  
Saber Hussain ◽  
Christin Grabinski ◽  
Nicole Schaeublin ◽  
Elizabeth Maurer ◽  
Mohan Sankaran ◽  
...  
Keyword(s):  
Risk Evaluation ◽  
Engineered Nanomaterials ◽  
Toxicity Evaluation ◽  
Evaluation Tools ◽  
Phase 3

Occupational Risk Assessment of Engineered Nanomaterials: Limits, Challenges and Opportunities

2016 ◽  
Vol 13 (1) ◽  
pp. 55-78 ◽  
Author(s):  
Veruscka Leso ◽  
Luca Fontana ◽  
Maria Mauriello ◽  
Ivo Iavicoli
Keyword(s):  
Risk Assessment ◽  
Occupational Risk ◽  
Engineered Nanomaterials ◽  
Challenges And Opportunities

Interference of Gold Nanoparticles with In vitro Endotoxin Detection Assays

2020 ◽  
Vol 16 (2) ◽  
pp. 204-213 ◽  
Author(s):  
Melissa A. Vetten ◽  
Mary Gulumian
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Surface Reactivity ◽  
In Vitro Assays ◽  
Limulus Amebocyte Lysate ◽  
Chromogenic Assay ◽  
Nanoparticle Suspensions ◽  
Endotoxin Contamination ◽  
Factor C

Background: Endotoxin-free engineered nanoparticle suspensions are imperative for their successful applications in the field of nanomedicine as well as in the investigations in their toxicity. Gold nanoparticles are known to interfere with various in vitro assays due to their optical properties and potential for surface reactivity. In vitro endotoxin testing assays are known to be susceptible to interference caused by the sample being tested. Objective: This study aimed to identify a preferred assay for the testing of endotoxin contamination in gold nanoparticle suspensions. Methods: The interference by gold nanoparticles on three assays namely, the commonly used limulus amebocyte lysate chromogenic assay, the limulus amebocyte lysate gel-clot method, and the less common recombinant Factor C (rFC) assay, was tested. Results: Possible interference could be observed with all three assays. The interference with the absorbance- based chromogenic assay could not be overcome by dilution; whilst the qualitative nature of the gel-clot assay excluded the possibility of distinguishing between a false positive result due to enhancement of the sensitivity of the assay, and genuine endotoxin contamination. However, interference with the rFC assay was easily overcome through dilution. Conclusion: The rFC assay is recommended as an option for endotoxin contamination detection in gold nanoparticle suspensions.

Hazards for Construction Workers

2017 ◽  
Author(s):  
Gavin H. West ◽  
Laura S. Welch
Keyword(s):  
Heavy Metals ◽  
Prevention And Control ◽  
Respiratory Diseases ◽  
Noise Exposure ◽  
Engineered Nanomaterials ◽  
Construction Workers ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
And Control ◽  
The Impact

This chapter describes the hazards for construction workers, with a particular focus on injuries as well as exposures to hazardous chemicals and dusts. A section describes hazardous exposures to lead and other heavy metals. Another section describes noise exposure. The impact of musculoskeletal disorders among construction workers is then discussed. A section on respiratory diseases focuses on asbestosis, silicosis, chronic obstructive pulmonary disease, and asthma. Exposures known to cause dermatitis and cancer are reviewed. There is a discussion of engineered nanomaterials as a potential emerging hazard. Various approaches to prevention and control, including regulations and health services, are described.

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