Complication with re‐sedation in southern Ground‐hornbills ( Bucorvus leadbeateri ) following partial reversal of two orally administered sedation protocols

2021 ◽  
Author(s):  
Liesel L. Laubscher ◽  
Katja Koeppel ◽  
Robert Campbell ◽  
Sarah Chabangu ◽  
Lucy V. Kemp
Keyword(s):  
Partial Reversal

scholarly journals Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

Blood ◽  
2012 ◽  
Vol 120 (17) ◽  
pp. 3555-3562 ◽  
Author(s):  
Dennis J. Goussetis ◽  
Elias Gounaris ◽  
Edward J. Wu ◽  
Eliza Vakana ◽  
Bhumika Sharma ◽  
...  
Keyword(s):  
Arsenic Trioxide ◽  
Chronic Myelogenous Leukemia ◽  
Cathepsin B ◽  
Myelogenous Leukemia ◽  
Molecular Targeting ◽  
Therapeutic Approaches ◽  
Subsequent Degradation ◽  
Autophagic Degradation ◽  
Partial Reversal

Abstract We provide evidence that arsenic trioxide (As2O3) targets the BCR-ABL oncoprotein via a novel mechanism involving p62/SQSTM1-mediated localization of the oncoprotein to the autolysosomes and subsequent degradation mediated by the protease cathepsin B. Our studies demonstrate that inhibitors of autophagy or cathepsin B activity and/or molecular targeting of p62/SQSTM1, Atg7, or cathepsin B result in partial reversal of the suppressive effects of AS2O3 on BCR-ABL expressing leukemic progenitors, including primitive leukemic precursors from chronic myelogenous leukemia (CML) patients. Altogether, these findings indicate that autophagic degradation of BCR-ABL is critical for the induction of the antileukemic effects of As2O3 and raise the potential for future therapeutic approaches to target BCR-ABL expressing cells by modulating elements of the autophagic machinery to promote BCR-ABL degradation.

Pyruvate kinase from the liver and kidney of Arapaima gigas

1978 ◽  
Vol 56 (4) ◽  
pp. 852-859 ◽  
Author(s):  
H. Guderley ◽  
J. H. A. Fields ◽  
J. M. Cardenas ◽  
P. W. Hochachka
Keyword(s):  
Pyruvate Kinase ◽  
Arapaima Gigas ◽  
Liver And Kidney ◽  
Low Levels ◽  
Pyruvate Kinases ◽  
Regulatory Properties ◽  
Partial Reversal

Pyruvate kinases from the kidney and liver of the osteoglossid Arapaima gigas were partially purified and characterized kinetically. The two enzymes have different elect rophoretic mobilities at pH 7.0, and while they share some qualitative similarities they show quantitative differences in their catalytic and regulatory properties. Both enzymes are activated by fructose 1.6-bisphosphate and inhibited by low levels of alanine and MgATP. The liver isozyme shows hyperbolic phosphoenolpyruvate binding, with a K1 for alanine inhibition of 0.7 mM and a K1 for MgATP inhibition of 1.0 mM. In contrast, the kidney isozyme shows cooperative phosphoenolpyruvate binding, which is accentuated at low levels of ADP. MgATP inhibition does not increase the cooperativity and shows an apparent K1 of 1.68 mM. The inhibition of alanine leads to considerable increases in the cooperativity and is effective at 1 mM and lower levels. Fructose 1.6-bisphosphate completely reverses the inhibition by alanine for both isozymes, while only leading to a partial reversal of the MgATP inhibition. These regulatory properties of both the kidney and the liver isozymes suit them for function in tissues which undergo both glycolysis and gluconeogenesis.

scholarly journals Altered levels of memory T cell subsets and common γc cytokines in Strongyloides stercoralis infection and partial reversal following anthelmintic treatment

2018 ◽  
Vol 12 (5) ◽  
pp. e0006481
Author(s):  
Anuradha Rajamanickam ◽  
Saravanan Munisankar ◽  
Yukti Bhootra ◽  
Chandra Kumar Dolla ◽  
Kannan Thiruvengadam ◽  
...  
Keyword(s):  
T Cell ◽  
Strongyloides Stercoralis ◽  
T Cell Subsets ◽  
Anthelmintic Treatment ◽  
Memory T Cell ◽  
Partial Reversal

scholarly journals A Climate for Abduction, a Climate for Redemption: The Politics of Inclusion during and after the Armenian Genocide

2013 ◽  
Vol 55 (3) ◽  
pp. 522-553 ◽  
Author(s):  
Lerna Ekmekcioglu
Keyword(s):  
World War I ◽  
Ethnic Group ◽  
Great Powers ◽  
Armenian Genocide ◽  
World War ◽  
Reverse Transfer ◽  
Depth Study ◽  
Women And Children ◽  
Turkish State ◽  
Partial Reversal

AbstractThis article explores a forcible, wartime transfer of women and minors from one ethnic group to another, and its partial reversal after the war. I analyze the historical conditions that enabled the original transfer, and then the circumstances that shaped the reverse transfer. The setting is Istanbul during and immediately after World War I, and the protagonists are various influential agents connected to the Ottoman Turkish state and to the Armenian Patriarchate. The absence and subsequent involvement of European Great Powers determines the broader, shifting context. The narrative follows the bodies of women and children, who were the subjects of the protagonists' discourses and the objects of their policies. This is the first in-depth study to connect these two processes involved: the wartime integration of Armenian women and children into Muslim settings, and postwar Armenian attempts to rescue, reintegrate, and redistribute them. I explain why and how the Armenian vorpahavak (gathering of orphans and widows) worked as it did, and situate it comparatively with similar events. I highlight its uniqueness, and the theoretical possibilities that it offers toward understanding why and how women, children, and reproduction matter to collectivities in crisis.

Depletion of mesolimbic dopamine during behavioral despair: Partial reversal by chronic imipramine

1993 ◽  
Vol 242 (3) ◽  
pp. 313-315 ◽  
Author(s):  
Zvani L. Rossetti ◽  
Marina Lai ◽  
Yousef Hmaidan ◽  
Gian Luigi Gessa
Keyword(s):  
Mesolimbic Dopamine ◽  
Behavioral Despair ◽  
Chronic Imipramine ◽  
Partial Reversal
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