scholarly journals Vascular characteristics and expression of hypoxia genes in Tibetan pigs’ hearts

2021 ◽  
Author(s):  
Yanan Yang ◽  
Caixia Gao ◽  
Tianliang Yang ◽  
Yuzhu Sha ◽  
Yuan Cai ◽  
...  
Keyword(s):  
Tibetan Pigs

scholarly journals Expression and hypoxia adaptation analysis of the EPO gene in different tissues of plateau Tibetan pigs

2015 ◽  
Vol 14 (1) ◽  
pp. 1700-1706 ◽  
Author(s):  
B.Z. Deji ◽  
P. Shang ◽  
W.J. Danzeng ◽  
H. Zhang ◽  
Y.Z. Qiangba
Keyword(s):  
Tibetan Pigs ◽  
Hypoxia Adaptation ◽  
Different Tissues

scholarly journals The Expression Regulatory Network in the Lung Tissue of Tibetan Pigs Provides Insight Into Hypoxia-Sensitive Pathways in High-Altitude Hypoxia

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanan Yang ◽  
Haonan Yuan ◽  
Tianliang Yang ◽  
Yongqing Li ◽  
Caixia Gao ◽  
...  
Keyword(s):  
High Altitude ◽  
Regulatory Networks ◽  
Alveolar Wall ◽  
Potential Candidate ◽  
Low Oxygen ◽  
Structure Damage ◽  
High Altitude Adaptation ◽  
Tibetan Pigs ◽  
Altitude Adaptation ◽  
Insight Into

To adapt to a low-oxygen environment, Tibetan pigs have developed a series of unique characteristics and can transport oxygen more effectively; however, the regulation of the associated processes in high-altitude animals remains elusive. We performed mRNA-seq and miRNA-seq, and we constructed coexpression regulatory networks of the lung tissues of Tibetan and Landrace pigs. HBB, AGT, COL1A2, and EPHX1 were identified as major regulators of hypoxia-induced genes that regulate blood pressure and circulation, and they were enriched in pathways related to signal transduction and angiogenesis, such as HIF-1, PI3K-Akt, mTOR, and AMPK. HBB may promote the combination of hemoglobin and oxygen as well as angiogenesis for high-altitude adaptation in Tibetan pigs. The expression of MMP2 showed a similar tendency of alveolar septum thickness among the four groups. These results indicated that MMP2 activity may lead to widening of the alveolar wall and septum, alveolar structure damage, and collapse of alveolar space with remarkable fibrosis. These findings provide a perspective on hypoxia-adaptive genes in the lungs in addition to insights into potential candidate genes in Tibetan pigs for further research in the field of high-altitude adaptation.

β-defensins gene expression in tissues of the crossbred and Tibetan pigs

2009 ◽  
Vol 123 (2-3) ◽  
pp. 161-168 ◽  
Author(s):  
Sharina Qi ◽  
Jinyong Chen ◽  
Rongfu Guo ◽  
Bing Yu ◽  
Daiwen Chen
Keyword(s):  
Gene Expression ◽  
Tibetan Pigs

Molecular Detection of Indigenous Hepatitis E Virus (HEV) from Tibetan Pigs in Tibet, China

2018 ◽  
Vol 10 (4) ◽  
pp. 373-377 ◽  
Author(s):  
Lihong Zhang ◽  
Shucheng Huang ◽  
Kun Li ◽  
Mujeeb Ur Rehman ◽  
Xiong Jiang ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Molecular Detection ◽  
Hepatitis E ◽  
Tibetan Pigs

scholarly journals High Altitude Adaptability and Meat Quality in Tibetan Pigs: A Reference for Local Pork Processing and Genetic Improvement

Animals ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1080 ◽  
Author(s):  
Mailin Gan ◽  
Linyuan Shen ◽  
Yuan Fan ◽  
Zhixian Guo ◽  
Bin Liu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
High Altitude ◽  
Meat Quality ◽  
Genetic Improvement ◽  
Essential Fatty Acids ◽  
Pcr Analysis ◽  
Pig Breeds ◽  
Tibetan Pigs ◽  
Yorkshire Pigs

The carcass and meat quality traits of pig breeds living at three different altitudes (Yorkshire pigs, YP: 500m; Qingyu Pigs, QYP: 1500m; Tibetan pigs, TP: 2500m) were compared. It was observed that there are obvious differences in pig breeds with respect to performance parameters. Specifically, YP had the best carcass traits, showing high slaughter rates and leanest meat. Conversely, QYP had the highest back fat thickness and intramuscular fat (IMF) content. For the high-altitude breed TP, the animals exhibited low L* and high a* values. The genotypes contributing to the observed phenotypes were supported by a PCR analysis. The glycolytic genes expression (HK, PFK, PK) were highest in YP, whereas expression of genes related to adipogenesis (C/EBPα, FABP4, SCD1) were highest in QYP. As expected, genes associated with angiogenesis and hypoxia (HIF1a, VEGFA) were expressed at the highest levels in TP. The composition and proportion of amino and fatty acids in pig muscles at the three altitudes examined also varied substantially. Among the breeds, TP had the highest proportion of umami amino acids, whereas QYP had the highest proportion of sweet amino acids. However, TP also exhibited the highest proportion of essential fatty acids and the lowest proportion of n6:n3. This study explains the high-altitude adaptive evolution and the formation of meat quality differences in different altitude pigs from various angles and provides a reference for local pork food processing and genetic improvement of local pigs.

Macrolide-Resistance Selection in Tibetan Pigs with a High Load ofMycoplasma hyopneumoniae

2018 ◽  
Vol 24 (7) ◽  
pp. 1043-1049 ◽  
Author(s):  
Gang Qiu ◽  
Yapei Rui ◽  
Jialu Zhang ◽  
Lihong Zhang ◽  
Shucheng Huang ◽  
...  
Keyword(s):  
High Load ◽  
Macrolide Resistance ◽  
Resistance Selection ◽  
Tibetan Pigs

Epidemiological survey of classical swine fever in Tibetan pigs in Nyingchi, Tibet China

2016 ◽  
Author(s):  
Jia-Kui Li ◽  
Hui Zhang ◽  
Peng Shang ◽  
Yangzom Chamba
Keyword(s):  
Classical Swine Fever ◽  
Epidemiological Survey ◽  
Economic Losses ◽  
Serum Samples ◽  
Immune Effect ◽  
Tibetan Pigs ◽  
Significant Difference ◽  
Long Time ◽  
The Government

Classical swine fever (CSF) is a major hazardous disease to the pigs and as a dangerous epidemic; it causes a serious economic losses to the pig industry. Though, a national compulsory immunization of CSF vaccines had been carried out for a long time, scarce information can be got about the immune effect of CSF in Tibetan pigs. The present study was to investigate the seroprevalence of CSF in Tibetan pigs in Nyingchi area of Tibet, China. A total 454 samples were collected from November 2014 to January 2015 and were investigated through enzyme-linked immuno sorbent assay (ELISA). The results showed that 241 (53.1%, 95% CI 48.4-57.8) pigs were found to be positive for CSF with the further distribution of 53.3% (95% CI 46.8–59.6), 49.5% (95% CI 42.2-56.8) and 93.8% (95% CI 69.8-99.8) in Tibetan counties of Nyingchi, Mainling and Gongbo'gyamda, respectively. There was no significant difference in male (52.8%, 95% CI 46.4-59.1) and female pigs (50.0%, 95% CI 42.6-57.4). Though, 53.1% of the serum samples were tested out positive to CSF, only the seroprevalence of CSF in Tibetan pigs in Gongbo'gyamda were higher than 70% which was ruled by the government. The low seroprevalence of CSF in Tibetan pigs should arise a serious concern and effective methods should be taken, in order to prevent CSF infection effectively.

scholarly journals Genetic Variation of EPAS1 Gene in Tibetan Pigs and Three Low-Altitude Pig Breeds in China

2014 ◽  
Vol 13 (9) ◽  
pp. 1990-1998 ◽  
Author(s):  
Kun-zhe DONG ◽  
Ye KANG ◽  
Na YAO ◽  
Guo-tao SHU ◽  
Qing-qing ZUO ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Pig Breeds ◽  
Tibetan Pigs ◽  
Low Altitude
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