scholarly journals Protective effect of pancreatic β -cells MIN6 by some medicinal plants in the Mekong Delta

2018 ◽  
Vol 56 (5) ◽  
pp. 637-641
Author(s):  
Le Thi Bach ◽  
Le Tien Dung ◽  
Nguyen Trong Tuan ◽  
Nguyen Thanh Phuong ◽  
Patrick Kestemont ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Protective Effect ◽  
Mekong Delta ◽  
Β Cells ◽  
Pancreatic Β Cells

Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model

2019 ◽  
Vol 24 (10) ◽  
pp. 1272-1277 ◽  
Author(s):  
Armin Mooranian ◽  
Nassim Zamani ◽  
Giuseppe Luna ◽  
Hesham Al-Sallami ◽  
Momir Mikov ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Bile Acid ◽  
Protective Effect ◽  
Murine Model ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Diabetes Development

AMPK α1 mediates the protective effect of adiponectin against insulin resistance in INS‐1 pancreatic β cells

2019 ◽  
Vol 37 (8) ◽  
pp. 625-632 ◽  
Author(s):  
Yan Wang ◽  
Yan Li ◽  
Jing Qiao ◽  
Na Li ◽  
Shun Qiao
Keyword(s):  
Insulin Resistance ◽  
Protective Effect ◽  
Β Cells ◽  
Pancreatic Β Cells

scholarly journals Protective Effect of Siegesbeckia orientalis on Pancreatic β-Cells under High Glucose-Induced Glucotoxicity

2021 ◽  
Vol 11 (22) ◽  
pp. 10963
Author(s):  
Chi-Chang Chang ◽  
Jer-Yiing Houng ◽  
Shih-Wei Wang ◽  
Chin-Feng Hsuan ◽  
Yung-Chuan Lu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Insulin Secretion ◽  
Protective Effect ◽  
Normal Level ◽  
High Glucose ◽  
Glucose Concentration ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Siegesbeckia Orientalis

The glucotoxicity caused by long-term exposure of β-cells to high glucose (HG) conditions may lead to the generation of more reactive oxygen species (ROS), reduce the activity of antioxidant enzymes, cause cell damage and apoptosis, and induce insulin secretion dysfunction. Siegesbeckia orientalis linne is a traditional folk herbal medicine used to treat snake bites, rheumatoid arthritis, allergies, and immune deficiencies. In this study, we evaluated the protective effect of S. orientalis ethanol extract (SOE) on cell death and oxidative stress in RIN-m5f pancreatic β-cells stimulated by two HG concentrations (50–100 mM). In the cell viability assay, SOE could significantly increase the survival rate of pancreatic β-cells under HG-induced conditions. For the oxidative stress induced by HG condition, the treatment of SOE effectively reduced the ROS formation, increased the content of intracellular glutathione, and up-regulated the expression of antioxidant enzymes, catalase, superoxide dismutase, and glutathione peroxidase. As a result, the SOE treatment could decrease the glucotoxicity-mediated oxidative damage on RIN-m5F β-cells. Moreover, SOE had the function of regulating insulin secretion in pancreatic β-cells under different HG-mediated conditions. It could decrease the increasing intracellular insulin secretion under the low glucose concentration to normal level; while increase the decreasing intracellular insulin secretion under the relatively high glucose concentration to normal level. Taken together, this study suggests that SOE has a protective effect on pancreatic β-cells under the HG-stimulated glucotoxic environment.

Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1α/TNF-α pathway and protective effect of taurine

2019 ◽  
Vol 125 ◽  
pp. 392-402 ◽  
Author(s):  
Pei Pei ◽  
Xiaofeng Yao ◽  
Liping Jiang ◽  
Tianming Qiu ◽  
Ningning Wang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Inorganic Arsenic ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Tnf Α

Protective effect of telmisartan on pancreatic β cells of type 2 diabetic rats

2008 ◽  
Vol 32 (3) ◽  
pp. S56-S56
Author(s):  
Ya Qi Chen ◽  
Wan Qin Xiao ◽  
Shao Wen Tian ◽  
Jing Zhang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Diabetic Rats ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Type 2 Diabetic

Protective effect of Schisandrae chinensis oil on pancreatic β-cells in diabetic rats

Endocrine ◽  
2014 ◽  
Vol 48 (3) ◽  
pp. 818-825 ◽  
Author(s):  
Liping An ◽  
Yingping Wang ◽  
Chunmei Wang ◽  
Meizhen Fan ◽  
Xiao Han ◽  
...  
Keyword(s):  
Protective Effect ◽  
Diabetic Rats ◽  
Β Cells ◽  
Pancreatic Β Cells
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