Protective Effect of Ginseng on Cytokine-Induced Apoptosis in Pancreatic β-Cells

2007 ◽  
Vol 55 (8) ◽  
pp. 2816-2823 ◽  
Author(s):  
Hye Young Kim ◽  
Kyong Kim
Keyword(s):  
Protective Effect ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Induced Apoptosis

scholarly journals Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1319 ◽  
Author(s):  
Tanyawan Suantawee ◽  
Thavaree Thilavech ◽  
Henrique Cheng ◽  
Sirichai Adisakwattana
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Oxidative Dna Damage ◽  
Inhibitory Effect ◽  
Protein Glycation ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Glyoxalase 1 ◽  
Its Gene ◽  
Induced Apoptosis

Recently, the mechanisms responsible for anti-glycation activity of cyanidin and its derivatives on the inhibition of methylglyoxal (MG)-induced protein glycation and advanced glycation-end products (AGEs) as well as oxidative DNA damage were reported. In this study, we investigated the protective effect of cyanidin against MG-induced oxidative stress and apoptosis in rat INS-1 pancreatic β-cells. Exposure of cells to cytotoxic levels of MG (500 µM) for 12 h caused a significant reduction in cell viability. However, the pretreatment of cells with cyanidin alone (6.25–100 μM) for 12 h, or cotreatment of cells with cyanidin (3.13–100 μM) and MG, protected against cell cytotoxicity. In the cotreatment condition, cyanidin (33.3 and 100 μM) also decreased MG-induced apoptosis as determined by caspase-3 activity. Furthermore, INS-1 cells treated with MG increased the generation of reactive oxygen species (ROS) during a 6 h exposure. The MG-induced increase in ROS production was inhibited by cyanidin (33.3 and 100 μM) after 3 h stimulation. Furthermore, MG diminished the activity of glyoxalase 1 (Glo-1) and its gene expression as well as the level of total glutathione. In contrast, cyanidin reversed the inhibitory effect of MG on Glo-1 activity and glutathione levels. Interestingly, cyanidin alone was capable of increasing Glo-1 activity and glutathione levels without affecting Glo-1 mRNA expression. These findings suggest that cyanidin exerts a protective effect against MG-induced oxidative stress and apoptosis in pancreatic β-cells by increasing the activity of Glo-1.

scholarly journals Novel protective effect of O-1602 and abnormal cannabidiol, GPR55 agonists, on ER stress-induced apoptosis in pancreatic β-cells

2019 ◽  
Vol 111 ◽  
pp. 1176-1186 ◽  
Author(s):  
Chi Teng Vong ◽  
Hisa Hui Ling Tseng ◽  
Yiu Wa Kwan ◽  
Simon Ming-Yuen Lee ◽  
Maggie Pui Man Hoi
Keyword(s):  
Protective Effect ◽  
Er Stress ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Induced Apoptosis

Delphinidin-induced autophagy protects pancreatic β cells against apoptosis resulting from high-glucose stress via AMPK signaling pathway

2019 ◽  
Vol 51 (12) ◽  
pp. 1242-1249 ◽  
Author(s):  
Dengni Lai ◽  
Mingyong Huang ◽  
Lingyan Zhao ◽  
Yan Tian ◽  
Yong Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
High Glucose ◽  
Cell Mass ◽  
Protective Role ◽  
Common Disease ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Ampk Signaling ◽  
Compound C ◽  
Induced Apoptosis

Abstract Hyperglycemia, a diagnostic characteristic of diabetes mellitus, is detrimental to pancreatic β cells. Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. However, whether delphinidin plays a protective role in pancreatic β-cell mass and function is not clear. In this study, delphinidin was found to decrease the high-glucose-induced apoptosis of RIN-m5F pancreatic β cells. In addition, delphinidin induced autophagy in RIN-m5F cells under the normal and high-glucose conditions, while 3-methyladenine (3-MA) inhibition of autophagy significantly diminished the protective role of delphinidin against high-glucose-induced apoptosis of pancreatic β cells. Delphinidin also decreased the level of cleaved caspase 3 and increased the phosphorylation level of AMP-activated protein kinase α (AMPKα) Thr172. Compound C, an AMPK inhibitor, was found to decrease the ratio of LC3-II/LC3-I, and the apoptotic rate of high-glucose-injured cells was increased after treatment with delphinidin, indicating that delphinidin attenuated the negative effects of high-glucose stress to cells. In conclusion, our data demonstrate that delphinidin protects pancreatic β cells against high-glucose-induced injury by autophagy regulation via the AMPK signaling pathway. These findings might shed light on the underlying mechanisms of diabetes and help improve the prevention and therapy of this common disease.

Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model

2019 ◽  
Vol 24 (10) ◽  
pp. 1272-1277 ◽  
Author(s):  
Armin Mooranian ◽  
Nassim Zamani ◽  
Giuseppe Luna ◽  
Hesham Al-Sallami ◽  
Momir Mikov ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Bile Acid ◽  
Protective Effect ◽  
Murine Model ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Diabetes Development

Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction

2016 ◽  
Vol 420 (1-2) ◽  
pp. 95-106 ◽  
Author(s):  
Hao-Hao Zhang ◽  
Xiao-Jun Ma ◽  
Li-Na Wu ◽  
Yan-Yan Zhao ◽  
Peng-Yu Zhang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Sirtuin 3 ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Induced Apoptosis

Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo

2017 ◽  
Vol 448 ◽  
pp. 108-121 ◽  
Author(s):  
Lukas A. Berchtold ◽  
Michela Miani ◽  
Thi A. Diep ◽  
Andreas N. Madsen ◽  
Valentina Cigliola ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Induced Apoptosis

AMPK α1 mediates the protective effect of adiponectin against insulin resistance in INS‐1 pancreatic β cells

2019 ◽  
Vol 37 (8) ◽  
pp. 625-632 ◽  
Author(s):  
Yan Wang ◽  
Yan Li ◽  
Jing Qiao ◽  
Na Li ◽  
Shun Qiao
Keyword(s):  
Insulin Resistance ◽  
Protective Effect ◽  
Β Cells ◽  
Pancreatic Β Cells
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