Polymorphisms of the prion‐related protein gene are strongly associated with cervids’ susceptibility to chronic wasting disease

2021 ◽  
Author(s):  
In‐Soon Roh ◽  
Yong‐Chan Kim ◽  
Hyo‐Jin Kim ◽  
Sae‐Young Won ◽  
Min‐Ju Jeong ◽  
...  
Keyword(s):  
Protein Gene ◽  
Chronic Wasting Disease ◽  
Related Protein ◽  
Wasting Disease

scholarly journals Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus)

Prion ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Mariella E. Güere ◽  
Jørn Våge ◽  
Helene Tharaldsen ◽  
Sylvie L. Benestad ◽  
Turid Vikøren ◽  
...  
Keyword(s):  
Prion Protein ◽  
Rangifer Tarandus ◽  
Protein Gene ◽  
Chronic Wasting Disease ◽  
Prion Protein Gene ◽  
Wasting Disease ◽  
Wild Reindeer

scholarly journals Prion protein gene sequence and chronic wasting disease susceptibility in white-tailed deer (Odocoileus virginianus)

Prion ◽  
2015 ◽  
Vol 9 (6) ◽  
pp. 449-462 ◽  
Author(s):  
Adam L Brandt ◽  
Amy C Kelly ◽  
Michelle L Green ◽  
Paul Shelton ◽  
Jan Novakofski ◽  
...  
Keyword(s):  
Odocoileus Virginianus ◽  
Prion Protein ◽  
Gene Sequence ◽  
Disease Susceptibility ◽  
Protein Gene ◽  
Chronic Wasting Disease ◽  
Prion Protein Gene ◽  
Wasting Disease

scholarly journals Prion Protein Gene (PRNP) Sequences Suggest Differing Vulnerability to Chronic Wasting Disease for Florida Key Deer (Odocoileus virginianus clavium) and Columbian White-Tailed Deer (O. v. leucurus)

2020 ◽  
Vol 111 (6) ◽  
pp. 564-572
Author(s):  
Tolulope I N Perrin-Stowe ◽  
Yasuko Ishida ◽  
Emily E Terrill ◽  
Brian C Hamlin ◽  
Linda Penfold ◽  
...  
Keyword(s):  
Odocoileus Virginianus ◽  
Prion Protein ◽  
Protein Gene ◽  
Chronic Wasting Disease ◽  
Synonymous Substitution ◽  
Spongiform Encephalopathy ◽  
Prion Protein Gene ◽  
Wasting Disease ◽  
Genetic Vulnerability ◽  
Key Deer

Abstract Chronic wasting disease (CWD) is a fatal, highly transmissible spongiform encephalopathy caused by an infectious prion protein. CWD is spreading across North American cervids. Studies of the prion protein gene (PRNP) in white-tailed deer (WTD; Odocoileus virginianus) have identified non-synonymous substitutions associated with reduced CWD frequency. Because CWD is spreading rapidly geographically, it may impact cervids of conservation concern. Here, we examined the genetic vulnerability to CWD of 2 subspecies of WTD: the endangered Florida Key deer (O. v. clavium) and the threatened Columbian WTD (O. v. leucurus). In Key deer (n = 48), we identified 3 haplotypes formed by 5 polymorphisms, of which 2 were non-synonymous. The polymorphism c.574G>A, unique to Key deer (29 of 96 chromosomes), encodes a non-synonymous substitution from valine to isoleucine at codon 192. In 91 of 96 chromosomes, Key deer carried c.286G>A (G96S), previously associated with substantially reduced susceptibility to CWD. Key deer may be less genetically susceptible to CWD than many mainland WTD populations. In Columbian WTD (n = 13), 2 haplotypes separated by one synonymous substitution (c.438C>T) were identified. All of the Columbian WTD carried alleles that in other mainland populations are associated with relatively high susceptibility to CWD. While larger sampling is needed, future management plans should consider that Columbian WTD are likely to be genetically more vulnerable to CWD than many other WTD populations. Finally, we suggest that genetic vulnerability to CWD be assessed by sequencing PRNP across other endangered cervids, both wild and in captive breeding facilities.

scholarly journals Chronic wasting disease in Norway – a survey of prion protein gene variation among cervids

2021 ◽  
Author(s):  
Mariella Evelyn Güere ◽  
Jørn Våge ◽  
Helene Tharaldsen ◽  
Kjersti Sternang Kvie ◽  
Bård‐Jørgen Bårdsen ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Chronic Wasting Disease ◽  
Prion Protein Gene ◽  
Wasting Disease ◽  
Gene Variation

scholarly journals Characterization of the prion protein gene in axis deer (Axis axis) and implications for susceptibility to chronic wasting disease

Prion ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 44-52
Author(s):  
Matthew J. Buchholz ◽  
Emily A. Wright ◽  
Blake A. Grisham ◽  
Robert D. Bradley ◽  
Thomas L. Arsuffi ◽  
...  
Keyword(s):  
Prion Protein ◽  
Protein Gene ◽  
Chronic Wasting Disease ◽  
Prion Protein Gene ◽  
Wasting Disease ◽  
Axis Axis ◽  
Axis Deer

scholarly journals Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Katayoun Moazami-Goudarzi ◽  
Olivier Andréoletti ◽  
Jean-Luc Vilotte ◽  
Vincent Béringue
Keyword(s):  
Animal Species ◽  
Protein Gene ◽  
Chronic Wasting Disease ◽  
Genetic Selection ◽  
Population Declines ◽  
Wasting Disease ◽  
Strain Diversity ◽  
Zoonotic Risk ◽  
Infectious Form ◽  
Free Ranging

AbstractTo date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting several captive, free ranging and wild cervid species. Responsible for marked population declines in North America, its geographical spread is now becoming a major concern in Europe. Polymorphisms in the prion protein gene (PRNP) are an important factor influencing the susceptibility to prions and their rate of propagation. All reported cervid PRNP genotypes are affected by CWD. However, in each species, some polymorphisms are associated with lower attack rates and slower progression of the disease. This has potential consequences in terms of genetic selection, CWD diffusion and strain evolution. CWD also presents a zoonotic risk due to prions capacity to cross species barriers. This review summarizes our current understanding of CWD control, focusing on PRNP genetic, strain diversity and capacity to infect other animal species, including humans.

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