OP35.07: In vitro fertilization does not predict fetal diagnosis of congenital heart disease

2011 ◽  
Vol 38 (S1) ◽  
pp. 157-157
Author(s):  
J. K. Votava-Smith ◽  
J. S. Glickstein ◽  
L. Simpson ◽  
I. A. Williams
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
In Vitro Fertilization ◽  
Congenital Heart ◽  
Fetal Diagnosis ◽  
Vitro Fertilization

scholarly journals Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease

2021 ◽  
Vol 14 (3) ◽  
pp. dmm047522
Author(s):  
Abdul Jalil Rufaihah ◽  
Ching Kit Chen ◽  
Choon Hwai Yap ◽  
Citra N. Z. Mattar
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Computational Models ◽  
Developing Heart ◽  
Heterogenous Group ◽  
In Silico Models ◽  
Large Animals

ABSTRACTBirth defects contribute to ∼0.3% of global infant mortality in the first month of life, and congenital heart disease (CHD) is the most common birth defect among newborns worldwide. Despite the significant impact on human health, most treatments available for this heterogenous group of disorders are palliative at best. For this reason, the complex process of cardiogenesis, governed by multiple interlinked and dose-dependent pathways, is well investigated. Tissue, animal and, more recently, computerized models of the developing heart have facilitated important discoveries that are helping us to understand the genetic, epigenetic and mechanobiological contributors to CHD aetiology. In this Review, we discuss the strengths and limitations of different models of normal and abnormal cardiogenesis, ranging from single-cell systems and 3D cardiac organoids, to small and large animals and organ-level computational models. These investigative tools have revealed a diversity of pathogenic mechanisms that contribute to CHD, including genetic pathways, epigenetic regulators and shear wall stresses, paving the way for new strategies for screening and non-surgical treatment of CHD. As we discuss in this Review, one of the most-valuable advances in recent years has been the creation of highly personalized platforms with which to study individual diseases in clinically relevant settings.

Usefulness of multidetector CT imaging to assess vascular stents in children with congenital heart disease: An in vivo and in vitro study

2008 ◽  
Vol 72 (4) ◽  
pp. 544-551 ◽  
Author(s):  
Joachim G. Eichhorn ◽  
Frederick R. Long ◽  
Claudia Jourdan ◽  
Johannes T. Heverhagen ◽  
Sharon L. Hill ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Multidetector Ct ◽  
In Vitro Study ◽  
Ct Imaging ◽  
Vitro Study ◽  
Vascular Stents

Patient-specific in vitro models for hemodynamic analysis of congenital heart disease – Additive manufacturing approach

2017 ◽  
Vol 54 ◽  
pp. 111-116 ◽  
Author(s):  
Rafael Medero ◽  
Sylvana García-Rodríguez ◽  
Christopher J. François ◽  
Alejandro Roldán-Alzate
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Additive Manufacturing ◽  
Congenital Heart ◽  
In Vitro Models ◽  
Patient Specific

P20 Impact on mode of delivery and early neonatal outcomes following fetal diagnosis of life-threatening congenital heart disease in the north east of england

Heart ◽  
2016 ◽  
Vol 102 (Suppl 1) ◽  
pp. A11.2-A11
Author(s):  
Albert Lim ◽  
Paul Moran ◽  
Maria Kontou ◽  
Wan Norshuhada Wan Montil ◽  
Majd Abu-Harb ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Mode Of Delivery ◽  
Neonatal Outcomes ◽  
Fetal Diagnosis ◽  
North East ◽  
The North ◽  
Life Threatening
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