scholarly journals OP08.09: Concurrent and contingency strategies using first trimester markers for the prediction of pre-eclampsia in women with a priori high risk

2009 ◽  
Vol 34 (S1) ◽  
pp. 87-87
Author(s):  
A. Khalil ◽  
N. Cowans ◽  
K. Spencer ◽  
S. Goichman ◽  
H. Meiri ◽  
...  
Keyword(s):  
High Risk ◽  
A Priori ◽  
First Trimester

First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk

2009 ◽  
Vol 29 (8) ◽  
pp. 781-789 ◽  
Author(s):  
Asma Khalil ◽  
Nicholas J. Cowans ◽  
Kevin Spencer ◽  
Sergey Goichman ◽  
Hamutal Meiri ◽  
...  
Keyword(s):  
High Risk ◽  
A Priori ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Protein

scholarly journals First trimester markers for the prediction of pre-eclampsia in women with a priori high risk

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Asma Khalil ◽  
Nicholas J Cowans ◽  
Kevin Spencer ◽  
Sergey Goichman ◽  
Hamutal Meiri ◽  
...  
Keyword(s):  
High Risk ◽  
A Priori ◽  
First Trimester

scholarly journals Patterns of antenatal care in low-versus high-risk pregnancies in Lebanon

2004 ◽  
Vol 10 (3) ◽  
pp. 268-276
Author(s):  
F. El Kak ◽  
M. Chaaya ◽  
O. Campbell ◽  
A. Kaddour
Keyword(s):  
High Risk ◽  
Antenatal Care ◽  
Laboratory Tests ◽  
Risk Groups ◽  
First Trimester ◽  
Pregnancy Risk ◽  
High Risk Women ◽  
Special Diets ◽  
Number Of Visits ◽  
Antenatal Visits

Westudied patterns of antenatal care in low- versus high-risk pregnancies in Lebanon comparing 538 women after delivery in urban Beirut with rural Baka’a. Most women had 9 antenatal care visits with an obstetrician, starting in the first trimester. Care for high-risk and low-risk pregnancies was similar in terms of type of provider, number of visits and timing of first visit. More high-risk women had advice about special diets, supplements and laboratory tests. Maternal and fetal outcomes showed that, controlling for area and pregnancy risk, more antenatal visits were associated with fewer preterm deliveries, more caesarean sections and fewer cases of postpartum depression. Overall, differences between risk groups were small

scholarly journals Disentangling vulnerability, state and trait features of neurocognitive impairments in depression

Brain ◽  
2020 ◽  
Author(s):  
Yuen-Siang Ang ◽  
Nicole Frontero ◽  
Emily Belleau ◽  
Diego A Pizzagalli
Keyword(s):  
Factor Analysis ◽  
High Risk ◽  
Model Comparison ◽  
A Priori ◽  
Low Risk ◽  
Cross Sectional ◽  
Brain Volumes ◽  
Neurocognitive Impairments ◽  
Bayesian Model Comparison ◽  
Depressed Children

Abstract Depression is a debilitating disorder that often starts manifesting in early childhood and peaks in onset during adolescence. Neurocognitive impairments have emerged as clinically important characteristics of depression, but it remains controversial which domains specifically index pre-existing vulnerability, state-related or trait-related markers. Here, we disentangled these effects by analysing the Adolescent Brain Cognitive Development dataset (n = 4626). Using information of participants’ current and past mental disorders, as well as family mental health history, we identified low-risk healthy (n = 2100), high-risk healthy (n = 2023), remitted depressed (n = 401) and currently depressed children (n = 102). Factor analysis of 11 cognitive variables was performed to elucidate latent structure and canonical correlation analyses conducted to probe regional brain volumes reliably associated with the cognitive factors. Bayesian model comparison of various a priori hypotheses differing in how low-risk healthy, high-risk healthy, remitted depressed and currently depressed children performed in various cognitive domains was performed. Factor analysis revealed three domains: language and reasoning, cognitive flexibility and memory recall. Deficits in language and reasoning ability, as well as in volumes of associated regions such as the middle temporal and superior frontal gyrus, represented state- and trait-related markers of depression but not pre-existing vulnerability. In contrast, there was no compelling evidence of impairments in other domains. These findings—although cross-sectional and specific to 9–10-year-old children—might have important clinical implications, suggesting that cognitive dysfunction may not be useful targets of preventive interventions. Depressed patients, even after remission, might also benefit from less commonly used treatments such as cognitive remediation therapy.

P5021Hypoperfusion markers identify patients with acute pulmonary embolism at highest risk for an adverse outcome

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Ebner ◽  
C Sentler ◽  
V P Harjola ◽  
H Bueno ◽  
K Keller ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Cardiac Arrest ◽  
High Risk ◽  
Predictive Value ◽  
Odds Ratio ◽  
Adverse Outcome ◽  
A Priori ◽  
Positive Likelihood Ratio ◽  
Adverse Outcomes ◽  
Prognostic Information

Abstract Background/Introduction According to the European Society of Cardiology (ESC) 2014 guideline, systemic hypotension (HT) is the critical variable defining high-risk in patients with pulmonary embolism (PE). However, signs of organ hypoperfusion might more adequately identify PE patients with cardiogenic shock due to right ventricular (RV) failure. Purpose We investigated whether hypoperfusion markers provide superior prognostic information for identifying PE patients at highest risk of early adverse outcomes. Methods Consecutive PE patients enrolled in a prospective single-centre registry between 09/2008 and 03/2018 were included. We analysed the predictive value of symptoms and findings suggesting hypoperfusion for in-hospital adverse outcome (catecholamine treatment, resuscitation or PE-related death) and in-hospital all-cause mortality. Results We analysed 814 patients, including 83 (10.2%) ESC 2014 high-risk patients. Patients presenting with cardiac arrest (CA, 4.5%) were a priori defined as high risk. Markers suggesting hypoperfusion of the brain (altered metal status, odds ratio [OR] 8.2 [95% CI, 4.2–16.0]), lung (respiratory insufficiency, 25.0 [9.4–66.7]) and tissue (venous lactate ≥2.2 mmol/l, 6.4 [3.2–12.9]) as well as HT (13.5 [6.7–27.2]) predicted an adverse outcome. The risk for an adverse outcome increased with the number of positive markers (AUC 0.86 [0.80–0.93]). Patients with ≥3 positive hypoperfusion markers had an OR of 42.9 (11.0–167.3) and patients defined as high-risk by the ESC 2014 an OR of 17.2 (8.8–33.3) with regard to an adverse outcome (Figure 1; Table 1). A new definition of high-risk (CA or ≥3 hypoperfusion markers) was associated with an OR of 73.2 (31.3–171.1) for an in-hospital adverse outcome and 26.2 (12.1–56.7) for in-hospital mortality. Table 1. Prognostic performance of hypoperfusion markers Adverse outcome (if negative) Adverse outcome (if positive) Sensitivity Specificity LR+ OR (95% CI) ≥1 hypoperfusion marker 1.1% 21.0% 91.9% 68.2% 2.9 24.4 (7.3–80.8) ≥2 hypoperfusion markers 4.7% 50.0% 48.6% 95.5% 10.9 20.3 (9.1–45.1) ≥3 hypoperfusion markers 6.5% 75.0% 24.3% 99.3% 32.7 42.9 (11.0–167.3) ESC 2014 high-risk 5.7% 51.1% 35.0% 96.9% 11.4 17.2 (8.8–33.3) Cardiac arrest 8.4% 86.5% 33.0% 99.3% 47.3 70.1 (26.4–186.1) Abbreviations: LR+, positive likelihood ratio; OR, odds ratio; CI, confidence interval. Figure 1. Frequency of adverse outcome Conclusions Markers of organ hypoperfusion have high predictive value for early adverse outcomes in acute PE. Risk increases with the number of positive markers and is critically elevated in patients presenting with CA or ≥3 markers. Acknowledgement/Funding This study was supported by the German Federal Ministry of Education and Research (BMBF 01EO1503).

Replication of pre-pregnancy or first-trimester risk scoring to identify women at high risk of preterm birth

2020 ◽  
Vol 245 ◽  
pp. 210-211
Author(s):  
Rebecca J. Baer ◽  
Elizabeth Jasper ◽  
John Dagle ◽  
Kelli K. Ryckman ◽  
John Dagle ◽  
...  
Keyword(s):  
Preterm Birth ◽  
High Risk ◽  
First Trimester ◽  
Risk Scoring
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