First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk

2009 ◽  
Vol 29 (8) ◽  
pp. 781-789 ◽  
Author(s):  
Asma Khalil ◽  
Nicholas J. Cowans ◽  
Kevin Spencer ◽  
Sergey Goichman ◽  
Hamutal Meiri ◽  
...  
Keyword(s):  
High Risk ◽  
A Priori ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Protein

scholarly journals OP08.08: Maternal serum placental protein 13 (PP13) testing to predict pre-eclampsia among first trimester high risk patients

2009 ◽  
Vol 34 (S1) ◽  
pp. 87-87
Author(s):  
N. Cowans ◽  
A. Stamatopoulou ◽  
K. Spencer ◽  
A. Khalil ◽  
J. Vaarno ◽  
...  
Keyword(s):  
High Risk ◽  
First Trimester ◽  
Maternal Serum ◽  
High Risk Patients ◽  
Risk Patients ◽  
Placental Protein

Assessment of first trimester maternal serum placental protein 13 for the prediction of IUGR with and without preeclampsia

2006 ◽  
Vol 195 (6) ◽  
pp. S151
Author(s):  
Gonen Ron ◽  
Ilana Chefetz ◽  
Yael Inna Grimpel ◽  
Marei Sammar ◽  
Hamutal Meiri
Keyword(s):  
First Trimester ◽  
Maternal Serum ◽  
Placental Protein

scholarly journals Potential screening strategies for early prediction of pre-eclampsia

2021 ◽  
Vol 10 (4) ◽  
pp. 1436
Author(s):  
Hymavathi K. ◽  
Sandhya Rani Davuluru ◽  
Sameera Shaik ◽  
Sahithi Kaviti
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Uterine Artery ◽  
Strong Association ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tools ◽  
Early Prediction ◽  
Inhibin A ◽  
Study Results

Background: This study was conducted to evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia.Methods: This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal serum inhibin A and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers were: chemiluminescence immunoassay (CLIA) for serum inhibin A levels, and uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer.Results: The present study revealed a significant rise of inhibin A in preeclamptic women when compared to normotensive women (p<0.0001). The mean levels of 1st and 2nd trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (p<0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal serum inhibin A, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE.Conclusions: Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, inhibin A. In our setting, MAP, UAPI, inhibin A, appeared to be better screening modalities. Combination of the biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

Placental protein-13 (PP13) in combination with PAPP-A and free leptin index (fLI) in first trimester maternal serum screening for severe and early preeclampsia

2017 ◽  
Vol 56 (1) ◽  
Author(s):  
Carin P. De Villiers ◽  
Paula L. Hedley ◽  
Sophie Placing ◽  
Karen R. Wøjdemann ◽  
Anne-Cathrine Shalmi ◽  
...  
Keyword(s):  
Detection Rate ◽  
False Positive Rate ◽  
First Trimester ◽  
Serum Marker ◽  
Maternal Serum ◽  
Maternal Serum Screening ◽  
Discriminatory Ability ◽  
Screening Performance ◽  
Positive Rate ◽  
Placental Protein

AbstractBackground:Placental protein-13 (PP13) is involved in placental invasion and has been suggested as a maternal serum marker of preeclampsia (PE) development. However, the discriminatory ability of PP13 in first trimester has not been completely clarified.Methods:PP13 was measured in first trimester (week 10Results:In severe PE (including HELLP) cases (n=26) the median PP13 concentration was 35.8 pg/mL (range: 17.8–85.5 pg/mL) and in PE pregnancies (n=10) with birth prior to week 34, the median PP13 concentration was 30.6 pg/mL (13.1–50.1 pg/mL), compared to controls with a median of 54.8 pg/mL (range: 15.4–142.6 pg/mL) (p<0.04). The population screening detection rate (DR) for a false-positive rate of 10% for severe PE and HELLP was 26% for PP13, 28% for PP13+PAPP-A, 33% for PP13+fLI, and 40% for PP13+PAPP-A+fLI.Conclusions:PP13 is a marker of severe PE and HELLP syndrome. The screening performance of PP13 can be markedly improved by combining it with fLI and PAPP-A.

First trimester maternal serum placental protein 13 levels in singleton vs. twin pregnancies with and without severe pre-eclampsia

2013 ◽  
Vol 0 (0) ◽  
pp. 1-6 ◽  
Author(s):  
Ran Svirsky ◽  
Hamutal Meiri ◽  
Ayelet Herzog ◽  
Vered Kivity ◽  
Howard Cuckle ◽  
...  
Keyword(s):  
First Trimester ◽  
Maternal Serum ◽  
Placental Protein ◽  
Twin Pregnancies

scholarly journals OP08.09: Concurrent and contingency strategies using first trimester markers for the prediction of pre-eclampsia in women with a priori high risk

2009 ◽  
Vol 34 (S1) ◽  
pp. 87-87
Author(s):  
A. Khalil ◽  
N. Cowans ◽  
K. Spencer ◽  
S. Goichman ◽  
H. Meiri ◽  
...  
Keyword(s):  
High Risk ◽  
A Priori ◽  
First Trimester

scholarly journals Relationship between first-trimester serum placental protein-13 and maternal characteristics, placental Doppler studies and pregnancy outcome

2016 ◽  
Vol 44 (5) ◽  
Author(s):  
Viola Seravalli ◽  
Yael Inna Grimpel ◽  
Hamutal Meiri ◽  
Miriam Blitzer ◽  
Ahmet A. Baschat
Keyword(s):  
Pregnancy Outcome ◽  
Gestational Age ◽  
Umbilical Artery ◽  
Adverse Pregnancy Outcome ◽  
First Trimester ◽  
Maternal Serum ◽  
Low Risk ◽  
Arterial Blood ◽  
Risk Patients ◽  
Placental Protein

AbstractTo examine potential correlations between maternal serum placental protein-13 (PP-13) and first trimester maternal and placental factors, and to evaluate the association of this marker with adverse pregnancy outcome.Serum samples from prospectively enrolled patients between 11 and 13 weeks and 6 days were analyzed for PP-13 using an ELISA assay. The relationships between maternal serum PP-13 levels and gestational age, maternal age, ethnicity, parity, smoking status, body mass index (BMI), mean arterial blood pressure, uterine and umbilical artery Doppler parameters were examined. The association between first-trimester PP-13 levels and subsequent pre-eclampsia and delivery of a small for gestational age (SGA) neonate was also investigated, after excluding patients who received aspirin.In 908 patients, PP-13 levels ranged from 8.0 to 537.5 pg/mL. A significant negative correlation was identified between PP13 and BMI (Spearman rho –0.20, P<0.0001). Smoking significantly decreased PP-13 (P<0.01). No relationship was identified with the other parameters. In a subgroup of 668 low-risk patients who did not receive aspirin, PP-13 levels were not associated with development of pre-eclampsia, SGA or the combination of them.First-trimester PP-13 levels are significantly correlated with BMI and smoking. These correlations appear independent of uterine and umbilical artery resistance. In low risk patients, PP-13 levels fail to predict the risk for pre-eclampsia or SGA.

scholarly journals First trimester markers for the prediction of pre-eclampsia in women with a priori high risk

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Asma Khalil ◽  
Nicholas J Cowans ◽  
Kevin Spencer ◽  
Sergey Goichman ◽  
Hamutal Meiri ◽  
...  
Keyword(s):  
High Risk ◽  
A Priori ◽  
First Trimester
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