scholarly journals First-trimester maternal serum level of pregnancy-associated plasma protein-A is an independent predictor of fetal maxillary bone length

2005 ◽  
Vol 27 (1) ◽  
pp. 9-12 ◽  
Author(s):  
T. Y. Leung ◽  
L. W. Chan ◽  
T. N. Leung ◽  
T. Y. Fung ◽  
D. S. Sahota ◽  
...  
Keyword(s):  
Serum Level ◽  
Plasma Protein ◽  
Independent Predictor ◽  
Protein A ◽  
First Trimester ◽  
Maternal Serum ◽  
Maxillary Bone ◽  
Bone Length

scholarly journals Correlation between first trimester fetal bone length and maternal serum pregnancy-associated plasma protein-A (PAPP-A)

2006 ◽  
Vol 21 (11) ◽  
pp. 3019-3021 ◽  
Author(s):  
Federico Prefumo ◽  
Silvana Canini ◽  
Angela Crovo ◽  
Daniela Pastorino ◽  
Pier Luigi Venturini ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Maternal Serum ◽  
Fetal Bone ◽  
Bone Length

Association between first-trimester maternal serum pregnancy-associated plasma protein-A and obstetric complications

2013 ◽  
Vol 33 (9) ◽  
pp. 839-847 ◽  
Author(s):  
Francesco D'Antonio ◽  
Claudia Rijo ◽  
Basky Thilaganathan ◽  
Ranjit Akolekar ◽  
Asma Khalil ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Protein A ◽  
First Trimester ◽  
Maternal Serum ◽  
Obstetric Complications

scholarly journals First Trimester Biochemical Screening for Trisomy 21: The Role of Free Beta hCG, Alpha Fetoprotein and Pregnancy Associated Plasma Protein A

1994 ◽  
Vol 31 (5) ◽  
pp. 447-454 ◽  
Author(s):  
K Spencer ◽  
D A Aitken ◽  
J A Crossley ◽  
G McCaw ◽  
E Berry ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Plasma Protein ◽  
Human Chorionic Gonadotropin ◽  
Trisomy 21 ◽  
False Positive Rate ◽  
Protein A ◽  
First Trimester ◽  
Serum Markers ◽  
Maternal Serum ◽  
Detection Rates

The potential efficacy of screening for trisomy 21 in the first trimester, using maternal serum markers α fetoprotein, free β human chorionic gonadotropin, unconjugated oestriol and pregnancy associated plasma protein A, was studied in an unselected population of women between the seventh and fourteenth week of gestation. Using a combination of α fetoprotein and free β human chorionic gonadotropin, 53% of affected pregnancies could be identified at a false positive rate of 5%. Unconjugated oestriol and pregnancy associated plasma protein A levels were lower in cases of trisomy 21, but their inclusion with other markers did not significantly improve detection rate. Monitoring the same pregnancies also in the second trimester showed that screening in the first trimester identified the same cases as in the second. We conclude that first trimester screening using free β human chorionic gonadotropin and α fetoprotein, is a viable possibility and will lead to detection rates in excess of 50%. Prospective studies are needed to confirm these observations.

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