scholarly journals OC12.03: Maternal obesity and congenital heart defects in the offspring: a Danish nationwide cohort study

2021 ◽  
Vol 58 (S1) ◽  
pp. 36-36
Author(s):  
G. Hedermann ◽  
I.N. Thagaard ◽  
P.L. Hedley ◽  
L. Krebs ◽  
C.M. Hagen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Maternal Obesity ◽  
Heart Defects

scholarly journals Prevalence of congenital heart defects in neuroblastoma patients: a cohort study and systematic review of literature

2008 ◽  
Vol 168 (9) ◽  
pp. 1081-1090 ◽  
Author(s):  
Klaartje van Engelen ◽  
Johannes H. M. Merks ◽  
Jan Lam ◽  
Leontien C. M. Kremer ◽  
Manouk Backes ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Study ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Review Of Literature

scholarly journals Intake of sucrose-sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in offspring: a Norwegian pregnancy cohort study

2019 ◽  
Vol 34 (4) ◽  
pp. 383-396 ◽  
Author(s):  
Maria T. Grønning Dale ◽  
Per Magnus ◽  
Elisabeth Leirgul ◽  
Henrik Holmstrøm ◽  
Håkon K. Gjessing ◽  
...  
Keyword(s):  
Cohort Study ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Pregnancy Cohort

scholarly journals Maternal psychological distress, education, household income, and congenital heart defects: a prospective cohort study from the Japan environment and children’s study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yasuaki Saijo ◽  
Eiji Yoshioka ◽  
Yukihiro Sato ◽  
Hiroshi Azuma ◽  
Yusuke Tanahashi ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Cohort Study ◽  
Psychological Distress ◽  
Congenital Heart Defects ◽  
Household Income ◽  
Prospective Cohort ◽  
Congenital Heart ◽  
Maternal Education ◽  
Heart Defects ◽  
Maternal Psychological Distress

Abstract Background The influence of maternal psychological distress on infant congenital heart defects (CHDs) has not been thoroughly investigated. Furthermore, there have been no reports on the combined effect of maternal psychological distress and socioeconomic status on infant CHDs. This study aimed to examine whether maternal psychological distress, socioeconomic status, and their combinations were associated with CHD. Methods We conducted a prospective cohort study using data from the Japan Environment and Children’s Study, which recruited pregnant women between 2011 and 2014. Maternal psychological distress was evaluated using the Kessler Psychological Distress Scale in the first trimester, while maternal education and household income were evaluated in the second and third trimesters. The outcome of infant CHD was determined using the medical records at 1 month of age and/or at birth. Crude- and confounder-adjusted logistic regression analyses were performed to evaluate the association between maternal psychological distress and education and household income on infant CHD. Results A total of 93,643 pairs of mothers and infants were analyzed, with 1.1% of infants having CHDs. Maternal psychological distress had a significantly higher odds ratio in the crude analysis but not in the adjusted analysis, while maternal education and household income were statistically insignificant. In the analysis of the combination variable of lowest education and psychological distress, the P for trend was statistically significant in the crude and multivariate model excluding anti-depressant medication, but the significance disappeared in the full model (P = 0.050). Conclusions The combination of maternal psychological distress and lower education may be a possible indicator of infant CHD.

scholarly journals Congenital heart defects of fetus after maternal exposure to organic and inorganic environmental factors: a cohort study

Oncotarget ◽  
2017 ◽  
Vol 8 (59) ◽  
pp. 100717-100723
Author(s):  
Wei Gong ◽  
Qianhong Liang ◽  
Dongming Zheng ◽  
Risheng Zhong ◽  
Yunjie Wen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Environmental Factors ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Maternal Exposure

scholarly journals Maternal Obesity and the Risk of Congenital Heart Defects: the Mediation Effect of Pregestational Diabetes

2021 ◽  
Author(s):  
Xiao-Xia Wu ◽  
Ru-Xiu Ge ◽  
Le Huang ◽  
Fu-Ying Tian ◽  
Yi-Xuan Chen ◽  
...  
Keyword(s):  
Risk Factor ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Maternal Education ◽  
Maternal Obesity ◽  
Heart Defects ◽  
Normal Weight ◽  
Mediation Effect ◽  
Pregestational Diabetes ◽  
Increased Risk

Abstract Background Congenital heart defects (CHDs) are the most common birth defects worldwide. Maternal obesity has been proposed as a risk factor for CHDs, but the results are controversial and inconclusive. Pregestational diabetes (PGDM) is well known as a risk factor for CHDs and is closely related to obesity. However, the effect of PGDM on the association between maternal obesity and CHDs has not been investigated.Objectives We aimed to explore the association between maternal obesity and CHDs and to further evaluate the mediation effect of PGDM on this association.Methods We involved 53708 mother-infant pairs with deliveries between 2017 and 2019 from the Birth Cohort in Shenzhen (BiCoS). Mothers were categorized into four groups: the underweight group (BMI < 18.5), normal weight group (18.5 ≤ BMI < 24), overweight group (24 ≤ BMI < 28) and obesity group (BMI ≥ 28). To evaluate the association between BMI and CHDs, we fit multivariable logistic regression models, adjusting for maternal age, maternal education level, mode of conception, parity, GDM and offspring sex. Mediation analysis was used to confirm the mediation effect of PGDM on the association between maternal obesity and CHDs.Results The proportion of obese individuals in the BiCoS was 2.11%. Overall, 372 (0.69%) infants were diagnosed with CHDs. The prevalence of CHDs in underweight, normal weight, overweight and obese individuals was 0.64%, 0.68%, 0.72% and 1.24%, respectively. Maternal obesity was associated with an increased risk of CHDs (OR=1.97, 95% CI 1.14–3.41). The offspring of women with PGDM were 6.88 times (95% CI 4.11–11.53) more likely to have CHDs than the offspring of mothers without PGDM. The mediation effect of PGDM on the association between maternal obesity and CHDs was significant (OR=1.18, 95% CI 1.06–1.32). The estimated mediation proportion was 24.83%.Conclusion Our findings suggested that maternal obesity was associated with CHDs and that PGDM partially mediated the association between maternal obesity and CHDs.

scholarly journals VP33.03: The diagnostic yield of prenatal genomic testing in congenital heart defects: a cohort study

2020 ◽  
Vol 56 (S1) ◽  
pp. 194-194
Author(s):  
F. Mone ◽  
B. Stott ◽  
S. Hamilton ◽  
A.N. Seale ◽  
E. Quinlan‐Jones ◽  
...  
Keyword(s):  
Cohort Study ◽  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Diagnostic Yield ◽  
Heart Defects ◽  
Genomic Testing
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