scholarly journals VP50.01: Quality assessment of first trimester uterine artery pulsatility index measurements in a pre‐eclampsia screening validation study

2020 ◽  
Vol 56 (S1) ◽  
pp. 284-285
Author(s):  
I. Riishede ◽  
A. Wright ◽  
D. Wright ◽  
P. Nørgaard ◽  
K. Pihl ◽  
...  
Keyword(s):  
Quality Assessment ◽  
Validation Study ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
First Trimester

scholarly journals Evaluation of oxidative/nitrative stress and uterine artery pulsatility index in early pregnancy

2021 ◽  
Vol 107 (4) ◽  
pp. 479-490
Author(s):  
D. Gerszi ◽  
Á. Penyige ◽  
Z. Mezei ◽  
B. Sárai-Szabó ◽  
R. Benkő ◽  
...  
Keyword(s):  
Birth Weight ◽  
Antioxidant Capacity ◽  
Pregnancy Outcomes ◽  
Total Antioxidant Capacity ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Color Doppler ◽  
First Trimester ◽  
Nitrative Stress ◽  
Total Antioxidant

AbstractIntroductionIncreased oxidative/nitrative stress is characteristic not only in pathologic, but also in healthy pregnancy. High uterine artery pulsatility index (UtAPI) at the end of the first trimester is associated with altered placentation and elevated risk for adverse pregnancy outcomes. We aimed to examine the relationship of systemic oxidative/nitrative stress and uterine artery pulsatility index in the first trimester and their correlation to pregnancy outcomes.Material and methodsHealthy pregnant women were recruited at 12–13th gestational week ultrasound examination; UtAPI was determined by color Doppler ultrasound. Patients were divided into high (UtAPI ≥ 2.3) (n = 30) and low (n = 31) resistance groups, and pregnancies were followed until labor. Systemic oxidative/nitrative stress was estimated by measuring total peroxide level, total antioxidant capacity and nitrotyrosine level.ResultsPlasma total peroxide level was significantly lower (2,510 ± 39 µM vs. 2,285 ± 59 µM), total antioxidant capacity was higher (781 ± 16 mM CRE vs. 822 ± 13 mM CRE) in the high UtAPI group, which were accompanied by lower birth weight (3,317 ± 64 vs. 3,517 ± 77 g, P < 0.05). Plasma total peroxide level showed a negative correlation (by Pearson) to UtAPI (P < 0.01) and positive correlation to birth weight (P < 0.05).ConclusionsAccording to our results, lower systemic oxidative stress showed correlation with high UtAPI measured between the 12–13th weeks of gestation. We also found significant differences in the birth weight of healthy newborns; therefore it is worth examining this relationship in pathological pregnancies.

First trimester uterine artery pulsatility index levels in euploid and aneuploid pregnancies

2019 ◽  
Vol 300 (6) ◽  
pp. 1559-1564
Author(s):  
Natalia Prodan ◽  
Philipp Wagner ◽  
Jiri Sonek ◽  
Markus Hoopmann ◽  
Armin Mutz ◽  
...  
Keyword(s):  
Pulsatility Index ◽  
Uterine Artery ◽  
First Trimester

scholarly journals Prediction of pre-eclampsia in early pregnancy using PAPP-A and uterine artery pulsatility index

2018 ◽  
Vol 7 (12) ◽  
pp. 5005
Author(s):  
Charu Pratap ◽  
Srishti Thakur
Keyword(s):  
Sensitivity And Specificity ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Protein A ◽  
Subsequent Development ◽  
First Trimester ◽  
Maternal Serum ◽  
Medical College ◽  
First Trimester Pregnancy ◽  
High Level

Background: The aim is to study the role of first trimester pregnancy associated plasma protein A (PAPP A) and second trimester uterine artery pulsatility index (PI) in prediction of pre-eclampsia in early pregnancy.Methods: This prospective study conducted at GSVM Medical College, Kanpur from May 2011 to May 2012 included 100 pregnant women. Serum PAPP-A level was determined in the first trimester (8-14 weeks) and uterine artery Doppler was done at 20-25 weeks of gestation.Results: Out of 100 patients 7 developed pre-eclampsia. Mean PAPP-A level in pre eclamptic and normotensive patients were 1.25±1.4 and 2.5±0.5ng/ml respectively. Mean PI level in pre eclamptic and normotensive patients were 1.77±0.28 and 0.96±0.25 respectively. The sensitivity and specificity of PAPP-A at cut off <1.7ng/ml was 71%, 71% respectively. The sensitivity and specificity of pulsatility index at cut off >1.4 was 100% ,94% respectively.Conclusions: Low level of maternal serum PAPP-A at 8-14weeks and high level of uterine artery PI at 22-25 weeks of pregnancy can predict subsequent development of pre-eclampsia.

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