scholarly journals OP19.06: Assessment of the first trimester uterine artery pulsatility index in Hong Kong Chinese pregnant women

2013 ◽  
Vol 42 (s1) ◽  
pp. 103-103
Author(s):  
D. S. Sahota ◽  
L. Law ◽  
Y. Ting ◽  
K. Cheng ◽  
T. Leung
Keyword(s):  
Hong Kong ◽  
Pregnant Women ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
First Trimester ◽  
Hong Kong Chinese

scholarly journals Evaluation of oxidative/nitrative stress and uterine artery pulsatility index in early pregnancy

2021 ◽  
Vol 107 (4) ◽  
pp. 479-490
Author(s):  
D. Gerszi ◽  
Á. Penyige ◽  
Z. Mezei ◽  
B. Sárai-Szabó ◽  
R. Benkő ◽  
...  
Keyword(s):  
Birth Weight ◽  
Antioxidant Capacity ◽  
Pregnancy Outcomes ◽  
Total Antioxidant Capacity ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Color Doppler ◽  
First Trimester ◽  
Nitrative Stress ◽  
Total Antioxidant

AbstractIntroductionIncreased oxidative/nitrative stress is characteristic not only in pathologic, but also in healthy pregnancy. High uterine artery pulsatility index (UtAPI) at the end of the first trimester is associated with altered placentation and elevated risk for adverse pregnancy outcomes. We aimed to examine the relationship of systemic oxidative/nitrative stress and uterine artery pulsatility index in the first trimester and their correlation to pregnancy outcomes.Material and methodsHealthy pregnant women were recruited at 12–13th gestational week ultrasound examination; UtAPI was determined by color Doppler ultrasound. Patients were divided into high (UtAPI ≥ 2.3) (n = 30) and low (n = 31) resistance groups, and pregnancies were followed until labor. Systemic oxidative/nitrative stress was estimated by measuring total peroxide level, total antioxidant capacity and nitrotyrosine level.ResultsPlasma total peroxide level was significantly lower (2,510 ± 39 µM vs. 2,285 ± 59 µM), total antioxidant capacity was higher (781 ± 16 mM CRE vs. 822 ± 13 mM CRE) in the high UtAPI group, which were accompanied by lower birth weight (3,317 ± 64 vs. 3,517 ± 77 g, P < 0.05). Plasma total peroxide level showed a negative correlation (by Pearson) to UtAPI (P < 0.01) and positive correlation to birth weight (P < 0.05).ConclusionsAccording to our results, lower systemic oxidative stress showed correlation with high UtAPI measured between the 12–13th weeks of gestation. We also found significant differences in the birth weight of healthy newborns; therefore it is worth examining this relationship in pathological pregnancies.

scholarly journals Potential screening strategies for early prediction of pre-eclampsia

2021 ◽  
Vol 10 (4) ◽  
pp. 1436
Author(s):  
Hymavathi K. ◽  
Sandhya Rani Davuluru ◽  
Sameera Shaik ◽  
Sahithi Kaviti
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Uterine Artery ◽  
Strong Association ◽  
First Trimester ◽  
Maternal Serum ◽  
Screening Tools ◽  
Early Prediction ◽  
Inhibin A ◽  
Study Results

Background: This study was conducted to evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia.Methods: This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal serum inhibin A and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers were: chemiluminescence immunoassay (CLIA) for serum inhibin A levels, and uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer.Results: The present study revealed a significant rise of inhibin A in preeclamptic women when compared to normotensive women (p<0.0001). The mean levels of 1st and 2nd trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (p<0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal serum inhibin A, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE.Conclusions: Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, inhibin A. In our setting, MAP, UAPI, inhibin A, appeared to be better screening modalities. Combination of the biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

scholarly journals Preeclampsia prediction –First trimester screening markers

2021 ◽  
Vol 8 (2) ◽  
pp. 223-229
Author(s):  
Kaliki Hymavathi ◽  
Bhaavya Paturi ◽  
Duvvuru Akshitha ◽  
K Sravya
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Uterine Artery ◽  
First Trimester ◽  
Screening Tools ◽  
Early Prediction ◽  
Creatinine Ratio ◽  
Spot Urine ◽  
Maternal Urine ◽  
Urine Albumin

Preeclampsia is a multi-system disorder manifested primarily by hypertension and proteinuria during second half of pregnancy. It is a major cause of maternal morbidity and mortality worldwide. Despite decades of research into the condition, the ability of clinicians to predict preeclampsia prior to the onset of symptoms has not improved significantly. In this review we will look at potential biomarkers for early prediction and diagnosis of preeclampsia. To evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia. This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal urine microalbumin, urinary albumin to creatinine ratio, and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers are: immunoturbidimetric method for urine albumin, modified kinetic Jaffe reaction without deproteinization for Urine creatinine and Uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer. In the present study, spot urine microalbumin and spot urine albumin to creatinine ratio (UACR) at 11-13 were significantly higher in women who developed PE subsequently when compared to nonpreeclamptic women.(P&#60;0.0001). The mean levels of 1st and 2nd-trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (P&#60;0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal urine microalbumin, albumin to creatinine ratio, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE. Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, microalbuminuria and urine albumin to creatinine ratio than the normotensive women. In our setting, MAP, UAPI, microalbuminuria, and UACR markers appeared to be better screening modalities. The combination of biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

First trimester uterine artery pulsatility index levels in euploid and aneuploid pregnancies

2019 ◽  
Vol 300 (6) ◽  
pp. 1559-1564
Author(s):  
Natalia Prodan ◽  
Philipp Wagner ◽  
Jiri Sonek ◽  
Markus Hoopmann ◽  
Armin Mutz ◽  
...  
Keyword(s):  
Pulsatility Index ◽  
Uterine Artery ◽  
First Trimester
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