First‐trimester accuracy of cell‐free DNA test for trisomy 21 screening in twin pregnancies

2020 ◽  
Author(s):  
E. Gottardi ◽  
J.‐M. Costa ◽  
P. Kleinfinger ◽  
L. Lohmann ◽  
J. Carrara ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
Cell Free Dna ◽  
Dna Test ◽  
Free Dna ◽  
Twin Pregnancies

Cell-free DNA analysis for trisomy 21 in first-trimester twin pregnancies

2019 ◽  
Vol 493 ◽  
pp. S596
Author(s):  
I. Vazquez Rico ◽  
P. Carrasco Salas ◽  
C. Santos Rosa ◽  
R. Granell Escobar ◽  
M.R. Torres Aguilar ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Dna Analysis ◽  
First Trimester ◽  
Cell Free Dna ◽  
Free Dna ◽  
Twin Pregnancies

First-Trimester Contingent Screening for Trisomy 21 by Fetal Nuchal Translucency and Maternal Serum Biomarkers and Maternal Blood Cell-Free DNA Testing

2018 ◽  
Vol 5 (3) ◽  
pp. 139-143
Author(s):  
Sarang Younesi ◽  
Shahram Savad ◽  
Soudeh Ghafouri-Fard ◽  
Mohammad Mahdi Taheri-Amin ◽  
Pourandokht Saadati ◽  
...  
Keyword(s):  
Blood Cell ◽  
Trisomy 21 ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Serum Biomarkers ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna

Cell-Free DNA Screening for Fetal Aneuploidy

2021 ◽  
pp. 115-120
Author(s):  
Ashley N. Battarbee ◽  
Neeta L. Vora
Keyword(s):  
Trisomy 21 ◽  
Dna Analysis ◽  
Chromosomal Abnormalities ◽  
Area Under The Curve ◽  
First Trimester ◽  
Outcome Data ◽  
Cell Free Dna ◽  
High Risk Women ◽  
Free Dna ◽  
Trimester Screening

In a prospective, multicenter blinded study at 35 international centers, the Noninvasive Examination of Trisomy (NEXT) study evaluated the performance of cell-free DNA screening for fetal trisomy compared to standard first trimester screening with nuchal translucency and serum analytes in a routine prenatal population. Among the 15,841 women who had standard screening and cell-free DNA analysis with neonatal outcome data, there were 68 chromosomal abnormalities (1 in 236). Of these, 38 were Trisomy 21 (1 in 417). Cell-free DNA analysis had a higher area under the curve (AUC) for trisomy 21, compared to standard screening (0.999 vs. 0.958, p = 0.001). Cell-free DNA analysis also had greater sensitivity, specificity, and positive predictive value compared to standard screening for trisomy 21, 18, and 13. While cell-free DNA analysis cannot detect all chromosome abnormalities, it performed better than standard screening for detection of trisomies 21, 18, and 13 in a routine population including low- and high-risk women.

Chromosome-selective sequencing of maternal plasma cell–free DNA for first-trimester detection of trisomy 21 and trisomy 18

2012 ◽  
Vol 206 (4) ◽  
pp. 322.e1-322.e5 ◽  
Author(s):  
Ghalia Ashoor ◽  
Argyro Syngelaki ◽  
Marion Wagner ◽  
Cahit Birdir ◽  
Kypros H. Nicolaides
Keyword(s):  
Plasma Cell ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Plasma ◽  
Trisomy 18 ◽  
Cell Free Dna ◽  
Free Dna ◽  
Selective Sequencing

scholarly journals First-trimester contingent screening for trisomy 21 by biomarkers and maternal blood cell-free DNA testing

2013 ◽  
Vol 42 (1) ◽  
pp. 41-50 ◽  
Author(s):  
K. H. Nicolaides ◽  
D. Wright ◽  
L. C. Poon ◽  
A. Syngelaki ◽  
M. M. Gil
Keyword(s):  
Blood Cell ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Blood ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals Cell-Free DNA Analysis for Trisomy Risk Assessment in First-Trimester Twin Pregnancies

2013 ◽  
Vol 35 (3) ◽  
pp. 204-211 ◽  
Author(s):  
M.M. Gil ◽  
Maria Soledad Quezada ◽  
Barbara Bregant ◽  
Argyro Syngelaki ◽  
Kypros H. Nicolaides
Keyword(s):  
Risk Assessment ◽  
Dna Analysis ◽  
First Trimester ◽  
Cell Free Dna ◽  
Free Dna ◽  
Twin Pregnancies

scholarly journals Screening for Common Fetal Trisomies in Twin Pregnancies: First-Trimester Combined, Cell-Free DNA, or Both?

2018 ◽  
Vol 46 (4) ◽  
pp. 217-222
Author(s):  
Lucia Pasquini ◽  
Ilaria Ponziani ◽  
Enrico Periti ◽  
Laura Marchi ◽  
Carlo Luchi ◽  
...  
Keyword(s):  
First Trimester ◽  
Cell Free Dna ◽  
Free Dna ◽  
Twin Pregnancies
Sign in / Sign up

Export Citation Format

Share Document