scholarly journals VP42.05: Case report: congenital atrioventricular block and fetal growth restriction in biamniotic bichorial twin pregnancy with of Ro/La autoantibodies

2020 ◽  
Vol 56 (S1) ◽  
pp. 241-241
Author(s):  
D.P. Luna Seguel ◽  
C. Martinovic ◽  
P. Vargas ◽  
C. Solari ◽  
J. Kusanovic ◽  
...  
Keyword(s):  
Case Report ◽  
Atrioventricular Block ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Twin Pregnancy ◽  
Growth Restriction ◽  
Congenital Atrioventricular Block

scholarly journals Potential effects of transdermal nitric oxide donor on fetal growth restriction and oligohydramnios: A case report

2020 ◽  
Vol 8 (12) ◽  
pp. 3288-3293
Author(s):  
Tsuyoshi Murata ◽  
Toma Fukuda ◽  
Tetsu Sato ◽  
Aya Kanno ◽  
Hyo Kyozuka ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Case Report ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Nitric Oxide Donor

Advanced tubal pregnancy associated with severe fetal growth restriction: a case report

2003 ◽  
Vol 13 (6) ◽  
pp. 422-425 ◽  
Author(s):  
T. Radaelli ◽  
G. Bulfamante ◽  
I. Cetin ◽  
A. M. Marconi ◽  
G. Pardi
Keyword(s):  
Case Report ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Tubal Pregnancy ◽  
Growth Restriction

scholarly journals Maternal sirolimus therapy and fetal growth restriction

2021 ◽  
Vol 8 (2) ◽  
pp. 19-24
Author(s):  
Sangay Tshering ◽  
Namkha Dorji ◽  
Youden Sonam
Keyword(s):  
Case Report ◽  
Signaling Pathway ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Mtor Signaling ◽  
Growth Restriction ◽  
Mtor Signaling Pathway ◽  
Epigenetic Modulation ◽  
In Pregnancy

Fetal growth restriction associated with continued maternal sirolimus therapy in pregnancy has not been reported. We hereby present a case of maternal sirolimus therapy resulting in fetal growth restriction and propose a multi-hit model. This hypothetic model is based on inhibition of mTOR signaling pathway and epigenetic modulation. This case report adds to the paucity of literature on continued monotherapeutic maternal sirolimus in pregnancy and its adverse fetal effects.

scholarly journals Case report: Klippel-Trenaunay-Weber syndrome associated with fetal growth restriction

1996 ◽  
Vol 11 (11) ◽  
pp. 2544-2545 ◽  
Author(s):  
G. Fait ◽  
Y. Daniel ◽  
M.J. Kupfenninc ◽  
I. Gull ◽  
M.R. Peyser ◽  
...  
Keyword(s):  
Case Report ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Weber Syndrome

scholarly journals OP0175 INTERNATIONAL MULTICENTRIC PROSPECTIVE STUDY ON PREGNANCY IN SYSTEMIC SCLEROSIS (IMPRESS-2)

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 105.1-105
Author(s):  
E. Tombetti ◽  
V. Ramoni ◽  
M. Betelli ◽  
Y. Allanore ◽  
M. Matucci Cerinic ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Pregnant Women ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Twin Pregnancy ◽  
Gestational Hypertension ◽  
Immunosuppressive Agents ◽  
Growth Restriction ◽  
Controlled Study ◽  
Obstetric Outcomes

Background:Data about the obstetric outcomes of pregnant women with Systemic Sclerosis (SSc) mainly derive from retrospective studies. Moreover, little evidence is available to define if pregnancy impacts on SSc course and if children of SSc mothers have a normal post-natal development.Objectives:To assessed the obstetric, pediatric and rheumatologic outcomes of SSc pregnancies in a prospective controlled studyMethods:Prospective recruitment of three cohorts.1) 110 pregnant women with SSc.2) 218 control pregnancies without systemic autoimmune diseases3) 78 non-pregnant control SSc with a matching subject in cohort-1.SSc was characterized for disease activity, severity, cutaneous/organ involvement and therapy. Women and their offspring were followed until 21 months after enrollment (ie, 12 months after expected delivery).Results:Gestational and neonatal outcomesMiscarriages and fetal death occurred in 7% and 5% of SSc pregnancies. Compared to control pregnancies, SSc pregnancies had higher rates of gestational hypertension (12% Vs 4%, p=0.004), pre-eclampsia (9% Vs 1%, p=0.002), fetal growth-restriction (13% Vs 4%, p=0.004), prematurity (26% Vs 7%, p<0.001) and cesarean section (52% Vs 4%, p=0.002). Newborns from SSc mothers weighted less (2773 Vs 3243g, p<0.001), were more frequently small for gestational age (SGA, 18% Vs 12%, p=0.05) and required neonatal-intensive care unit (ICU) more frequently (12% Vs 1%, p<0.001). Rates of newborn malformation/death, and one year-pediatric outcomes were similar.Univariate and multivariate analyses were performed for relevant outcomes. For example, pre-eclampsia positively associated with baseline skin score and its evolution during pregnancy (p=0.015 and 0.013), immunosuppressive agents, bosentan and iloprost at baseline (p=0.001, 0.041 and 0.007), and twin pregnancy(p=0.006). Multivariate logistic regression for pre-eclampsia in SSc identified baseline arterial hypertension, immunosuppressive agents or of iloprost, twin pregnancy and assisted conception as risk factors (p=0.000, 0.002, 0.0025, 0.000 and 0.027), and baseline calcium channel blockers as protective factors (p=0.001).SSc course during pregnancyAs compared to matched non-pregnant SSc, SSc pregnant women had lower Medsger disease severity index (0.6 +/-0.9 Vs 1.0 +/-1.1, p=0.022), health assessment questionnaire (HAQ, 0.21 +/-0.38 Vs 0.40 +/-0.55, p=0.026), and lower rate of iv iloprost (21% Vs 42%, p=0.006). Pregnant and non-pregnant SSc women had a similar disease course during the 21 months of follow-up, despite a lower use of immunosuppressive agents (17% Vs 36%, p=0.014). Two scleroderma-renal-crises (SRC) occurred during pregnancy (one was a relapse of a previous SRC; the other occurred at week 33, and resolved after premature delivery of a SGA newborn and ACE-inhibitors, preventing differentiation from pre-eclampsia).Conclusion:SSc pregnancies have generally a favorable obstetric/pediatric outcome, albeit at a higher risk of gestational hypertension, pre-eclampsia, fetal growth restriction, prematurity, delivery of SGA newborn and requirement of neonatal-ICU. Pregnancy does not impact on SSc course, although SRC during late pregnancy and pre-eclampsia might be hardly discriminated.References:[1]Taraborelli M et al., Arthritis Rheum, 2012.Disclosure of Interests:None declared

scholarly journals Placental Cyst-a Rare Cause of Fetal Growth Restriction - A Case Report

2021 ◽  
Vol 7 (2) ◽  
pp. 109-111
Author(s):  
H P Sapna ◽  
◽  
T N Harsha ◽  
Gaana Sreenivas
Keyword(s):  
Case Report ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction

scholarly journals Case Report: Candidate Genes Associated With Prenatal Ultrasound Anomalies in a Fetus With Prenatally Detected 1q23.3q31.2 Deletion

2021 ◽  
Vol 12 ◽  
Author(s):  
Jiahao Song ◽  
Qian Zhang ◽  
Bing Lu ◽  
Zhongshan Gou ◽  
Ting Wang ◽  
...  
Keyword(s):  
Case Report ◽  
Prenatal Diagnosis ◽  
Fetal Growth ◽  
Coronary Sinus ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis ◽  
Phenotype Correlation ◽  
Renal Hypoplasia

Background: Patients with deletions involving the long arm of chromosome 1 are rare, and the main aim of this study was to refine the genotype-phenotype correlation.Case Report: In this report, a 28-year-old pregnant woman, gravida 2 para 1, at 25+4 weeks of gestation underwent ultrasound examination in our institute. The ultrasonographic findings of the fetus were as follows: (1) fetal growth restriction; (2) cleft lip and palate; (3) bilateral renal hypoplasia; (4) lateral ventriculomegaly; (5) single umbilical artery; (6) absent stomach; (7) coronary sinus dilatation with persistent left superior vena cava, ventricular septal defect and unroofed coronary sinus syndrome. Chromosomal microarray analysis of amniotic fluid from the fetus revealed a 28.025 Mb deletion in 1q23.3q31.2, spanning from position 164,559,675 to 192,584,768 (hg19).Conclusion: Genotype-phenotype correlation might improve prenatal diagnosis of fetuses with chromosome 1q deletion. PBX1 could be a candidate gene for fetal growth restriction, renal hypoplasia and congenital heart disease. Fetal growth restriction was accompanied by decreased renal volume in the fetus. Combined with ultrasonic examination, the application of chromosomal microarray analysis will provide accurate prenatal diagnosis.

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