scholarly journals OC17.04: Assessment of fetal hemodynamics and flow volume of the umbilical vein in the EXTrauterine environment for neonatal development system

2019 ◽  
Vol 54 (S1) ◽  
pp. 42-43
Author(s):  
K. Ozawa ◽  
M. Davey ◽  
Z. Tian ◽  
M. Hornick ◽  
A.Y. Mejaddam ◽  
...  
Keyword(s):  
Umbilical Vein ◽  
Flow Volume ◽  
Neonatal Development ◽  
Development System

scholarly journals Quantification of blood flow in the fetus with cardiovascular magnetic resonance imaging using Doppler ultrasound gating: validation against metric optimized gating

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Daniel Salehi ◽  
Liqun Sun ◽  
Katarina Steding-Ehrenborg ◽  
Sebastian Bidhult ◽  
Fabian Kording ◽  
...  
Keyword(s):  
Blood Flow ◽  
Phase Contrast ◽  
Umbilical Vein ◽  
Region Of Interest ◽  
Reference Method ◽  
Vessel Diameter ◽  
Observer Variability ◽  
Flow Volume ◽  
Flow Measurements ◽  
Time Resolved

Abstract Introduction Fetal cardiovascular magnetic resonance (CMR) imaging is used clinically and for research, but has been previously limited due to lack of direct gating methods. A CMR-compatible Doppler ultrasound (DUS) gating device has resolved this. However, the DUS-gating method is not validated against the current reference method for fetal phase-contrast blood flow measurements, metric optimized gating (MOG). Further, we investigated how different methods for vessel delineation affect flow volumes and observer variability in fetal flow acquisitions. Aims To 1) validate DUS gating versus MOG for quantifying fetal blood flow; 2) assess repeatability of DUS gating; 3) assess impact of region of interest (ROI) size on flow volume; and 4) compare time-resolved and static delineations for flow volume and observer variability. Methods Phase-contrast CMR was acquired in the fetal descending aorta (DAo) and umbilical vein by DUS gating and MOG in 22 women with singleton pregnancy in gestational week 360 (265–400) with repeated scans in six fetuses. Impact of ROI size on measured flow was assessed for ROI:s 50–150% of the vessel diameter. Four observers from two centers provided time-resolved and static delineations. Bland-Altman analysis was used to determine agreement between both observers and methods. Results DAo flow was 726 (348–1130) ml/min and umbilical vein flow 366 (150–782) ml/min by DUS gating. Bias±SD for DUS-gating versus MOG were − 45 ± 122 ml/min (−6 ± 15%) for DAo and 19 ± 136 ml/min (2 ± 24%) for umbilical vein flow. Repeated flow measurements in the same fetus showed similar volumes (median CoV = 11% (DAo) and 23% (umbilical vein)). Region of interest 50–150% of vessel diameter yielded flow 35–120%. Bias±SD for time-resolved versus static DUS-gated flow was 33 ± 39 ml/min (4 ± 6%) for DAo and 11 ± 84 ml/min (2 ± 15%) for umbilical vein flow. Conclusions Quantification of blood flow in the fetal DAo and umbilical vein using DUS-gated phase-contrast CMR is feasible and agrees with the current reference method. Repeatability was generally high for CMR fetal blood flow assessment. An ROI similar to the vessel area or slightly larger is recommended. A static ROI is sufficient for fetal flow quantification using currently available CMR sequences.

Z ‐Score Reference Ranges for Umbilical Vein Diameter and Blood Flow Volume in Normal Fetuses

2021 ◽  
Author(s):  
Ling Wang ◽  
Qichang Zhou ◽  
Chunhui Zhou ◽  
Jiqing Wang ◽  
Chunlan Shi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Umbilical Vein ◽  
Reference Ranges ◽  
Flow Volume ◽  
Z Score ◽  
Blood Flow Volume ◽  
Vein Diameter

Ultrastructure of the Omphalomesenteric Duct Rest in the Umbilical Cord at Term

1982 ◽  
Vol 40 ◽  
pp. 250-251
Author(s):  
B. A. Clark ◽  
T. Okagaki
Keyword(s):  
Umbilical Cord ◽  
Umbilical Vein ◽  
Meckel’S Diverticulum ◽  
Meckel's Diverticulum ◽  
Columnar Epithelium ◽  
Omphalomesenteric Duct ◽  
Umbilical Arteries

Vestiges of the omphalomesenteric or vitello-intestinal duct and the pathologic implications attributed to these remnants have been treated in great detail by several investigators. Persistence of the omphalomesenteric duct is associated with such conditions as Meckel's diverticulum, umbilical fistula, mucosal polyps, and sinuses or cysts of the umbilicus. Remnants of the duct in the umbilical cord, although infrequent, are located outside of the triangle formed by the two umbilical arteries and the umbilical vein, are usually discontinuous and are often represented by a small lumen lined by cuboidal or columnar epithelium. This study will examine the ultrastructure of these cells.

Ultrastructural observations on the in vitro cytoadherence of Plasmodium falciparum infected red blood cells

1990 ◽  
Vol 48 (3) ◽  
pp. 914-915
Author(s):  
D.J.P. Ferguson ◽  
A.R. Berendt ◽  
J. Tansey ◽  
K. Marsh ◽  
C.I. Newbold
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Umbilical Vein ◽  
Cell Types ◽  
Amelanotic Melanoma ◽  
Cytoplasmic Process ◽  
Umbilical Vein Endothelial Cells

In human malaria, the most serious clinical manifestation is cerebral malaria (CM) due to infection with Plasmodium falciparum. The pathology of CM is thought to relate to the fact that red blood cells containing mature forms of the parasite (PRBC) cytoadhere or sequester to post capillary venules of various tissues including the brain. This in vivo phenomenon has been studied in vitro by examining the cytoadherence of PRBCs to various cell types and purified proteins. To date, three Ijiost receptor molecules have been identified; CD36, ICAM-1 and thrombospondin. The specific changes in the PRBC membrane which mediate cytoadherence are less well understood, but they include the sub-membranous deposition of electron-dense material resulting in surface deformations called knobs. Knobs were thought to be essential for cytoadherence, lput recent work has shown that certain knob-negative (K-) lines can cytoadhere. In the present study, we have used electron microscopy to re-examine the interactions between K+ PRBCs and both C32 amelanotic melanoma cells and human umbilical vein endothelial cells (HUVEC).We confirm previous data demonstrating that C32 cells possess numerous microvilli which adhere to the PRBC, mainly via the knobs (Fig. 1). In contrast, the HUVEC were relatively smooth and the PRBCs appeared partially flattened onto the cell surface (Fig. 2). Furthermore, many of the PRBCs exhibited an invagination of the limiting membrane in the attachment zone, often containing a cytoplasmic process from the endothelial cell (Fig. 2).

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