scholarly journals OP02.04: The association between maternal prepregnancy obesity and congenital malformations in offspring

2018 ◽  
Vol 52 ◽  
pp. 70-70
Author(s):  
H. Choi ◽  
S. Kim ◽  
M. Oh ◽  
G. Cho
Keyword(s):  
Congenital Malformations ◽  
Prepregnancy Obesity ◽  
Maternal Prepregnancy Obesity

Are observed associations between a high maternal prepregnancy body mass index and offspring IQ likely to be causal?

2019 ◽  
Vol 73 (10) ◽  
pp. 920-928 ◽  
Author(s):  
Helen Coo ◽  
Leandre Fabrigar ◽  
Gregory Davies ◽  
Renee Fitzpatrick ◽  
Michael Flavin
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Maternal Obesity ◽  
Normal Weight ◽  
Offspring Performance ◽  
Logistic Regression Models ◽  
Prepregnancy Body Mass Index ◽  
Parents And Children ◽  
Prepregnancy Obesity ◽  
Maternal Prepregnancy Obesity

BackgroundA high maternal prepregnancy body mass index has been associated with lower offspring IQ, but it is unclear if the relationship is causal. To explore this, our objectives were to compare maternal and paternal estimates and to assess whether certain factors mediate the association.MethodsWe analysed data from the Avon Longitudinal Study of Parents and Children, which initially recruited 14 541 women residing in Avon, UK, with an expected date of delivery in 1991–1992. Data were collected during and after pregnancy by questionnaire, medical record abstraction and clinical assessment. At approximately 8 years of age, psychologists administered an abbreviated form of the Wechsler Intelligence Scale for Children-III. We fit multivariable logistic regression models to estimate parental prepregnancy obesity and overweight–offspring IQ associations. Counterfactually defined indirect (mediated) effects of maternal prepregnancy obesity on offspring IQ were estimated through path analysis.ResultsAmong 4324 mother–father–child triads and using normal weight as the referent, we observed consistently stronger associations for maternal prepregnancy obesity and offspring performance IQ (eg, adjusted β (95% CI)=−3.4 (−5.7 to −1.2) vs −0.97 (−2.9 to 0.96) for paternal obesity). The indirect effects of maternal obesity on offspring IQ through pathways involving gestational weight gain and duration of breastfeeding were small but significant.ConclusionOur findings are consistent with a weak biologic effect of maternal adiposity in pregnancy on offspring performance IQ. Given the growing prevalence of obesity worldwide, more evidence is needed to resolve the correlation versus causation debate in this area.

scholarly journals Maternal prepregnancy obesity and cause-specific stillbirth

2015 ◽  
Vol 102 (4) ◽  
pp. 858-864 ◽  
Author(s):  
Lisa M Bodnar ◽  
W Tony Parks ◽  
Kiran Perkins ◽  
Sarah J Pugh ◽  
Robert W Platt ◽  
...  
Keyword(s):  
Prepregnancy Obesity ◽  
Maternal Prepregnancy Obesity

scholarly journals Maternal prepregnancy obesity and achievement of infant motor developmental milestones in the upstate KIDS study

Obesity ◽  
2015 ◽  
Vol 23 (4) ◽  
pp. 907-913 ◽  
Author(s):  
Amanda Wylie ◽  
Rajeshwari Sundaram ◽  
Christopher Kus ◽  
Akhgar Ghassabian ◽  
Edwina H. Yeung
Keyword(s):  
Developmental Milestones ◽  
Prepregnancy Obesity ◽  
Maternal Prepregnancy Obesity

scholarly journals Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity

2017 ◽  
Vol 125 (6) ◽  
pp. 067005 ◽  
Author(s):  
Guangyun Mao ◽  
Rebecca Massa Nachman ◽  
Qi Sun ◽  
Xingyou Zhang ◽  
Kirsten Koehler ◽  
...  
Keyword(s):  
Early Life ◽  
Childhood Overweight ◽  
Joint Effects ◽  
Prepregnancy Obesity ◽  
Pm2.5 Exposure ◽  
Maternal Prepregnancy Obesity ◽  
Overweight Or Obesity

Maternal Prepregnancy Obesity is an Independent Risk Factor for Frequent Wheezing in Infants by Age 14 Months

2012 ◽  
Vol 27 (1) ◽  
pp. 100-108 ◽  
Author(s):  
Stefano Guerra ◽  
Claudio Sartini ◽  
Michelle Mendez ◽  
Eva Morales ◽  
Mònica Guxens ◽  
...  
Keyword(s):  
Risk Factor ◽  
Independent Risk Factor ◽  
Prepregnancy Obesity ◽  
Maternal Prepregnancy Obesity

scholarly journals Maternal prepregnancy obesity and child neurodevelopment in the Collaborative Perinatal Project

2014 ◽  
Vol 43 (3) ◽  
pp. 783-792 ◽  
Author(s):  
Lisu Huang ◽  
Xiaodan Yu ◽  
Sarah Keim ◽  
Ling Li ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Child Neurodevelopment ◽  
Prepregnancy Obesity ◽  
Maternal Prepregnancy Obesity
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