scholarly journals Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity

2017 ◽  
Vol 125 (6) ◽  
pp. 067005 ◽  
Author(s):  
Guangyun Mao ◽  
Rebecca Massa Nachman ◽  
Qi Sun ◽  
Xingyou Zhang ◽  
Kirsten Koehler ◽  
...  
Keyword(s):  
Early Life ◽  
Childhood Overweight ◽  
Joint Effects ◽  
Prepregnancy Obesity ◽  
Pm2.5 Exposure ◽  
Maternal Prepregnancy Obesity ◽  
Overweight Or Obesity

Early-life exposures predicting onset and resolution of childhood overweight or obesity

2017 ◽  
Vol 102 (10) ◽  
pp. 915-922 ◽  
Author(s):  
Jessica A Kerr ◽  
Catherine Long ◽  
Susan A Clifford ◽  
Joshua Muller ◽  
Alanna N Gillespie ◽  
...  
Keyword(s):  
Early Life ◽  
Childhood Overweight ◽  
Early Life Exposures ◽  
Overweight Or Obesity

scholarly journals Patterns of early life body mass index and childhood overweight and obesity status at eight years of age

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Joseph M. Braun ◽  
Heidi J. Kalkwarf ◽  
George D. Papandonatos ◽  
Aimin Chen ◽  
Bruce P. Lanphear
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Early Life ◽  
Childhood Overweight ◽  
Overweight And Obesity ◽  
Childhood Overweight And Obesity ◽  
Obesity Status

scholarly journals Exploring the impact of early life factors on inequalities in risk of overweight in UK children: findings from the UK Millennium Cohort Study

2016 ◽  
Vol 101 (8) ◽  
pp. 724-730 ◽  
Author(s):  
Samuel Massion ◽  
Sophie Wickham ◽  
Anna Pearce ◽  
Ben Barr ◽  
Catherine Law ◽  
...  
Keyword(s):  
Early Life ◽  
Social Inequalities ◽  
Childhood Overweight ◽  
Smoking During Pregnancy ◽  
The Social ◽  
Maternal Smoking During Pregnancy ◽  
Early Life Factors ◽  
Uk Millennium Cohort Study ◽  
The Uk ◽  
Academic Qualifications

BackgroundOverweight and obesity in childhood are socially patterned, with higher prevalence in more disadvantaged populations, but it is unclear to what extent early life factors attenuate the social inequalities found in childhood overweight/obesity.MethodsWe estimated relative risks (RRs) for being overweight (combining with obesity) at age 11 in 11 764 children from the UK Millennium Cohort Study (MCS) according to socio-economic circumstances (SEC). Early life risk factors were explored to assess if they attenuated associations between SECs and overweight.Results28.84% of children were overweight at 11 years. Children of mothers with no academic qualifications were more likely to be overweight (RR 1.72, 95% CI 1.48 to 2.01) compared to children of mothers with degrees and higher degrees. Controlling for prenatal, perinatal, and early life characteristics (particularly maternal pre-pregnancy overweight and maternal smoking during pregnancy) reduced the RR for overweight to 1.44, 95% CI 1.23 to 1.69 in the group with the lowest academic qualifications compared to the highest.ConclusionsWe observed a clear social gradient in overweight 11-year-old children using a representative UK sample. Moreover, we identified specific early life risk factors, including maternal smoking during pregnancy and maternal pre-pregnancy overweight, that partially account for the social inequalities found in childhood overweight. Policies to support mothers to maintain a healthy weight, breastfeed and abstain from smoking during pregnancy are important to improve maternal and child health outcomes, and our study provides some evidence that they may also help to address the continuing rise in inequalities in childhood overweight.

Are observed associations between a high maternal prepregnancy body mass index and offspring IQ likely to be causal?

2019 ◽  
Vol 73 (10) ◽  
pp. 920-928 ◽  
Author(s):  
Helen Coo ◽  
Leandre Fabrigar ◽  
Gregory Davies ◽  
Renee Fitzpatrick ◽  
Michael Flavin
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Maternal Obesity ◽  
Normal Weight ◽  
Offspring Performance ◽  
Logistic Regression Models ◽  
Prepregnancy Body Mass Index ◽  
Parents And Children ◽  
Prepregnancy Obesity ◽  
Maternal Prepregnancy Obesity

BackgroundA high maternal prepregnancy body mass index has been associated with lower offspring IQ, but it is unclear if the relationship is causal. To explore this, our objectives were to compare maternal and paternal estimates and to assess whether certain factors mediate the association.MethodsWe analysed data from the Avon Longitudinal Study of Parents and Children, which initially recruited 14 541 women residing in Avon, UK, with an expected date of delivery in 1991–1992. Data were collected during and after pregnancy by questionnaire, medical record abstraction and clinical assessment. At approximately 8 years of age, psychologists administered an abbreviated form of the Wechsler Intelligence Scale for Children-III. We fit multivariable logistic regression models to estimate parental prepregnancy obesity and overweight–offspring IQ associations. Counterfactually defined indirect (mediated) effects of maternal prepregnancy obesity on offspring IQ were estimated through path analysis.ResultsAmong 4324 mother–father–child triads and using normal weight as the referent, we observed consistently stronger associations for maternal prepregnancy obesity and offspring performance IQ (eg, adjusted β (95% CI)=−3.4 (−5.7 to −1.2) vs −0.97 (−2.9 to 0.96) for paternal obesity). The indirect effects of maternal obesity on offspring IQ through pathways involving gestational weight gain and duration of breastfeeding were small but significant.ConclusionOur findings are consistent with a weak biologic effect of maternal adiposity in pregnancy on offspring performance IQ. Given the growing prevalence of obesity worldwide, more evidence is needed to resolve the correlation versus causation debate in this area.

scholarly journals Maternal prepregnancy obesity and cause-specific stillbirth

2015 ◽  
Vol 102 (4) ◽  
pp. 858-864 ◽  
Author(s):  
Lisa M Bodnar ◽  
W Tony Parks ◽  
Kiran Perkins ◽  
Sarah J Pugh ◽  
Robert W Platt ◽  
...  
Keyword(s):  
Prepregnancy Obesity ◽  
Maternal Prepregnancy Obesity
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