scholarly journals OC08.03: Subjective and objective strategies to assess myometrial invasion and cervical stromal invasion in women with endometrial cancer from the IETA cohort

2018 ◽  
Vol 52 ◽  
pp. 17-17
Author(s):  
J.Y. Verbakel ◽  
F. Mascilini ◽  
D. Fischerová ◽  
A.C. Testa ◽  
D. Franchi ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Myometrial Invasion ◽  
Stromal Invasion ◽  
Cervical Stromal Invasion

scholarly journals A Nomogram Model Involving Immunohistochemical Markers for Predicting the Recurrence of Stage I-II Endometrial Cancer

2021 ◽  
Vol 10 ◽  
Author(s):  
Peng Jiang ◽  
Mingzhu Jia ◽  
Jing Hu ◽  
Zhen Huang ◽  
Ying Deng ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Validation Cohort ◽  
Myometrial Invasion ◽  
Stage I ◽  
Stromal Invasion ◽  
Training Cohort ◽  
Immunohistochemical Markers ◽  
Cervical Stromal Invasion ◽  
Classical Parameters ◽  
Medical University

BackgroundThe purpose of this study was to establish a nomogram combining classical parameters and immunohistochemical markers to predict the recurrence of patients with stage I-II endometrial cancer (EC).Methods419 patients with stage I-II endometrial cancer who received primary surgical treatment at the First Affiliated Hospital of Chongqing Medical University were involved in this study as a training cohort. Univariate and multivariate Cox regression analysis of screening prognostic factors were performed in the training cohort to develop a nomogram model, which was further validated in 248 patients (validation cohort) from the Second Affiliated Hospital of Chongqing Medical University. The calibration curve was used for internal and external verification of the model, and the C-index was used for comparison among different models.ResultsThere were 51 recurrent cases in the training cohort while 31 cases in the validation cohort. Univariate analysis showed that age, histological type, histological grade, myometrial invasion, cervical stromal invasion, postoperative adjuvant treatment, and four immunohistochemical makers (Ki67, estrogen receptor, progesterone receptor, P53) were the related factors for recurrence of EC. Multivariate analysis demonstrated that histological type (P = 0.029), myometrial invasion (P = 0.003), cervical stromal invasion (P = 0.001), Ki67 (P < 0.001), ER (P = 0.009) and P53 expression (P = 0.041) were statistically correlated with recurrence of EC. Recurrence-free survival was better predicted by the proposed nomogram with a C-index of 0.832 (95% CI, 0.752–0.912) in the training cohort, and the validation set confirmed the finding with a C-index of 0.861 (95% CI, 0.755–0.967).ConclusionThe nomogram model combining classical parameters and immunohistochemical markers can better predict the recurrence in patients with FIGO stage I-II EC.

Extent of cervical involvement in endometrial cancer as a predictor of outcome

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e16566-e16566
Author(s):  
J. S. Ferriss ◽  
W. Brix ◽  
M. Henretta ◽  
K. Hanley ◽  
M. Stoler ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Myometrial Invasion ◽  
Stage Ii ◽  
Inclusion Criteria ◽  
Stromal Invasion ◽  
Risk Of Recurrence ◽  
Increased Risk ◽  
Cervical Stromal Invasion ◽  
Cervical Involvement

e16566 Background: Endometrial cancer will affect 40,000 women this year. Extent of myometrial invasion and presence of cervical stromal disease are risk-factors for metastasis and recurrence. Uterine cervical involvement is often not known in advance of surgery, and superficial involvement may not be seen at frozen section. The objective of this study was to determine if the extent of cervical invasion is a predictor of outcome. Methods: The institutional cancer registry was searched for cases of stage II uterine cancer from 1996–2006. Inclusion criteria were endometrioid histology and clinical data and pathology available for evaluation. Demographics, extent of surgery, tumor grade, depth of myometrial invasion, presence of lymph-vascular space invasion (LVSI), and last follow up were collected. In addition, a gynecologic pathologist evaluated all slides to determine depth of cervical stromal invasion. Statistical analysis to compare predictors of outcome was performed. Results: There were 800 cases of endometrial cancer diagnosed from 1996–2006, 75 (9%) were stage II. Fifty two cases met all inclusion criteria. Mean age at diagnosis was 63.4 years. Mean BMI was 31.6. Ninety four percent were white, 4% black, and 2% Asian. All patients had a hysterectomy, 6 (11.5%) had a radical hysterectomy and 36 (69%) had lymphadenectomy performed. Eighteen (34.6%) were stage IIA and 32 (61.5%) were IIB. LVSI was seen in 15 (28.8%) cases. On pathologic review, 37.5% had no cervical stromal invasion, 42.5% had invasion of less than half and 20% had invasion of more than half of the cervical stroma. Forty patients (77%) received adjuvant radiation. There were 8 recurrences and 6 disease-related deaths. The mean follow up period was 30 months. Extent of cervical invasion did not correlate with recurrence or survival. Factors associated with increased risk of recurrence were: LVSI (p = 0.017), lack of lymph node sampling (p = 0.035), and age >55 years (p = 0.027). Women with and without recurrence were compared and did not significantly differ. Conclusions: In this study with pathologic review, extent of cervical involvement in stage II endometrial cancer was not associated with increased risk of recurrence or death. Age >55 years, lack of node sampling and presence of LVSI were predictors of recurrent disease. No significant financial relationships to disclose.

scholarly journals Association of Abnormal Pap Smear with Occult Cervical Stromal Invasion in Patients with Endometrial Cancer

2019 ◽  
Vol 20 (9) ◽  
pp. 2847-2850
Author(s):  
Kewalin Khumthong ◽  
Apiwat Aue-Aungkul ◽  
Pilaiwan Kleebkaow ◽  
Bandit Chumworathayi ◽  
Amornrat Temtanakitpaisan ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Pap Smear ◽  
Stromal Invasion ◽  
Cervical Stromal Invasion

Cervical Stromal Invasion Predicting Survival in Endometrial Cancer

2010 ◽  
Vol 116 (5) ◽  
pp. 1035-1041 ◽  
Author(s):  
J. Stuart Ferriss ◽  
William Brix ◽  
Rosemary Tambouret ◽  
Christopher P. DeSimone ◽  
Mark Stoler ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Stromal Invasion ◽  
Cervical Stromal Invasion

Vaginal brachytherapy alone for patients with Stage II endometrial cancer with inner half cervical stromal invasion

Brachytherapy ◽  
2019 ◽  
Vol 18 (5) ◽  
pp. 606-611 ◽  
Author(s):  
Elizabeth A. Barnes ◽  
Carlos Parra-Herran ◽  
Kevin Martell ◽  
Lisa Barbera ◽  
Amandeep Taggar ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Stage Ii ◽  
Stromal Invasion ◽  
Cervical Stromal Invasion
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