scholarly journals OP25.08: Prognostic value of intra-amniotic interleukin-6 and cervical length in monochorionic twins after fetal surgery

2017 ◽  
Vol 50 ◽  
pp. 131-131
Author(s):  
J. Vojtech ◽  
V.J. Dvorak ◽  
L. Haslik ◽  
K. Mackova ◽  
K. Behavkova ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Prognostic Value ◽  
Fetal Surgery ◽  
Cervical Length ◽  
Monochorionic Twins

Prognostic value of intraamniotic interleukin-6 and cervical length in monochorionic twins after fetal surgery

2019 ◽  
Vol 234 ◽  
pp. e45
Author(s):  
Radovan Pock ◽  
Jiri Vojtech ◽  
Vladimir Dvorak ◽  
Lubomir Haslik ◽  
Petra Hanulikova ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Prognostic Value ◽  
Fetal Surgery ◽  
Cervical Length ◽  
Monochorionic Twins

scholarly journals P-211 Prognostic value of interleukin-6 in colon cancer patients: A prospective study in 60 Tunisian patients

2020 ◽  
Vol 31 ◽  
pp. S159
Author(s):  
I. Ben Abdallah ◽  
J. Ayari ◽  
R. Guesmi ◽  
S. Soua ◽  
S. Fendri ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prospective Study ◽  
Cancer Patients ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Tunisian Patients ◽  
A Prospective Study

Prognostic value of the biomarkers procalcitonin, interleukin-6 and C-reactive protein in severe sepsis

2012 ◽  
Vol 36 (8) ◽  
pp. 556-562
Author(s):  
V. Miguel-Bayarri ◽  
E.B. Casanoves-Laparra ◽  
L. Pallás-Beneyto ◽  
S. Sancho-Chinesta ◽  
L.F. Martín-Osorio ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Prognostic value of plasma interleukin-6 levels in patients with chronic lymphocytic leukemia

Cancer ◽  
2002 ◽  
Vol 95 (5) ◽  
pp. 1071-1075 ◽  
Author(s):  
Raymond Lai ◽  
Susan O'Brien ◽  
Taghi Maushouri ◽  
Anna Rogers ◽  
Hagop Kantarjian ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Lymphocytic Leukemia

Prognostic value of serum interleukin-6 and YKL-40 and systemic inflammatory response in patients with unresectable pancreatic cancer.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 267-267
Author(s):  
Inna Chen ◽  
Christian Dehlendorff ◽  
Benny Vittrup Jensen ◽  
Per Pfeiffer ◽  
Jon K. Bjerregaard ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Inflammatory Response ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Univariate Analysis ◽  
White Blood Cells ◽  
Multivariable Analysis ◽  
Laboratory Data ◽  
Cox Proportional Hazards ◽  
Systemic Inflammatory Response

267 Background: Interleukin-6 (IL-6) and YKL-40 (CHI3L1) are produced by pancreatic cancer (PC) cells and macrophages and activate inflammation. The aim of this prospective-retrospective biomarker study was to determine the prognostic value of serum IL-6 and YKL-40 and systemic inflammatory response in patients with PC receiving palliative chemotherapy. Methods: 625 patients with PC (M/F: 283/342; age <70 vs. ≥70: 395/230; ECOG PS of 0/1/2/3: 214/315/92/4; stage 3 vs. 4: 129/496; treated with gemcitabine n=437, FOLFIRINOX n=117, gemcitabine and nab-Paclitaxel n=54 or other n=17) were included in the BIOPAC biomarker study from 5 hospitals in Denmark. Pretreatment serum values of IL-6 (R&D Systems), YKL-40 (Quidel), and CA 19-9 (Siemens) were determined. Patients were grouped as low vs. high, dichotomized using cut-off for IL-6 > 4.92 pg/ml, for CA19-9 > 2183 U/ml and for YKL-40 > 95% age-corrected percentile. The main outcome was overall survival (OS) and hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were computed using Cox proportional hazards regression. Results: 598 (95.7%) patients died during follow-up. In univariate analysis elevated IL-6 (HR 1.93, 95% CI 1.63-2.28) and elevated YKL-40 (HR 1.74, 95% CI 1.47-2.05) were associated with short OS. Similar results were found if IL-6 and YKL-40 were included as continuous log2-transformed variables. Multivariable analysis showed that elevated IL-6 (HR 1.61, 95% CI 1.33-1.94), elevated YKL-40 (HR 1.36, 95% CI 1.13-1.64), elevated CA19-9 (HR 1.30, 95% CI 1.09-1.56), higher PS (1 vs. 0; HR 1.46, 95% CI 1.21-1.77 and PS 2 vs. 0; HR 2.73, 95% CI 2.08-3.58) and stage 4 vs. 3 (HR 1.79, 95% CI 1.44-2.24) were independently associated with a poor OS. In a subgroup of 386 patients with available laboratory data, higher C-reactive protein (HR 1.20, 95% CI 1.13-1.26), white blood cells (HR 1.41, 1.17-1.71) and absolute neutrophils count (HR 1.35, 95% CI 1.15-1.59) log2-transformed and adjusted for age, sex, PS, CA 19-9 and stage were associated with short OS. Conclusions: Serum IL-6, YKL-40 and CA19-9 along with CRP, WBC and ANC are independent prognostic biomarkers in patients with unresectable PC.

Patterns and prognostic value of troponin, interleukin-6, and leptin after pediatric open-heart surgery

2009 ◽  
Vol 24 (3) ◽  
pp. 419-425 ◽  
Author(s):  
Dalit Modan-Moses ◽  
Anat Prince ◽  
Hannah Kanety ◽  
Clara Pariente ◽  
Ovdi Dagan ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Prognostic Value ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

scholarly journals Prognostic value of circulating levels of interleukin-6 in patients with congestive heart failure

1998 ◽  
Vol 31 ◽  
pp. 248
Author(s):  
E. Roig ◽  
J. Orús ◽  
C. Paré ◽  
M. Azqueta ◽  
F. Pérez-Villa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Circulating Levels

scholarly journals Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions

2019 ◽  
Author(s):  
Juhyun Song ◽  
Dae Won Park ◽  
Sungwoo Moon ◽  
Han-Jin Cho ◽  
Jong Hak Park ◽  
...  
Keyword(s):  
Septic Shock ◽  
Interleukin 6 ◽  
Prognostic Value ◽  
Controlled Study ◽  
Pentraxin 3 ◽  
Clinical Value ◽  
International Consensus ◽  
Sepsis And Septic Shock ◽  
Diagnostic And Prognostic Value

Abstract Background: This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods: Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 hours of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results: Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83–0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71-0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (≥ 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003–1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001). Conclusions: The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.

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