scholarly journals OC06.06: The ultrasound-measured tumor-free distance (uTDF) is a valuable predictor of lymph node status in endometrial cancer

2014 ◽  
Vol 44 (S1) ◽  
pp. 15-15
Author(s):  
M. Liro ◽  
M. Sniadecki ◽  
E. Wycinka ◽  
S. Wojtylak ◽  
A. Bianek ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Status ◽  
Free Distance ◽  
Node Status ◽  
Valuable Predictor

scholarly journals A systematic review of tests for lymph node status in primary endometrial cancer

2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Tara J Selman ◽  
Christopher H Mann ◽  
Javier Zamora ◽  
Khalid S Khan
Keyword(s):  
Systematic Review ◽  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Status ◽  
Node Status

scholarly journals Challenges Posed by Embryonic and Anatomical Factors in Systematic Lymphadenectomy for Endometrial Cancer

2020 ◽  
Vol 9 (12) ◽  
pp. 4107
Author(s):  
Damaris Freytag ◽  
Julian Pape ◽  
Juhi Dhanawat ◽  
Veronika Günther ◽  
Nicolai Maass ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Surgical Staging ◽  
Current Evidence ◽  
Lymph Node Status ◽  
Prognostic Information ◽  
Systematic Lymphadenectomy ◽  
Lymph Node Mapping ◽  
Node Status ◽  
Wide Range

Lymph node involvement has been shown to be one of the most relevant prognostic factors in a variety of malignancies; this is also true of endometrial cancer. The determination of the lymph node status is crucial in order to establish the tumor stage, and to consider adjuvant treatment. A wide range of surgical staging practices are currently used for the treatment of endometrial cancer. The necessity and extent of lymph node dissection is an ongoing controversial issue in gynecological oncology. Lymph node surgery in endometrial cancer is technically challenging, and can be time consuming because of the topographic complexity of lymphatic drainage as such, and the fact that the lymph nodes are directly adjacent to both blood vessels and nerves. Therefore, profound and exact knowledge of the anatomy is essential. Sentinel lymph node mapping was recently introduced in surgical staging with the aim of reducing morbidity, whilst also obtaining useful prognostic information from a patient’s lymph node status. The present review summarizes the current evidence on the role of lymph node surgery in endometrial cancer, focusing on the embryological, anatomical, and technical aspects.

Relationship of lymph node status with survival and recurrence among women with endometrial cancer

2020 ◽  
Vol 151 (2) ◽  
pp. 267-271
Author(s):  
Osman Cagin Buldukoglu ◽  
Alev Turker ◽  
Alp Usubutun ◽  
Mehmet Coskun Salman
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Status ◽  
Node Status ◽  
Relationship Of

Lymph Node Status Did Not Significantly Improve the Predictability of Survival in Patients With Clinically Early-Stage Endometrial Cancer

2014 ◽  
Vol 24 (8) ◽  
pp. 1449-1454
Author(s):  
Hyo Sook Bae ◽  
Jong-Min Lee ◽  
Jae-Kwan Lee ◽  
Jae-Weon Kim ◽  
Chi-Heum Cho ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Early Stage ◽  
Lymph Node Status ◽  
Survival Prediction ◽  
Concordance Index ◽  
Node Metastasis ◽  
Node Status ◽  
Early Stage Endometrial Cancer ◽  
Cause Specific Survival

ObjectiveThe aim of this study was to determine whether knowledge of lymph node status improves survival prediction in clinically early-stage endometrial cancer.MethodsThe records of 661 patients with apparently uterine-confined disease were reviewed. The performance in predicting overall survival and cause-specific survival was compared between a multivariate prognostic model with nodal status and a model without nodal status by calculating Harrell concordance index.ResultsAmong 661 patients with clinically early-stage endometrial cancer, the lymph node metastasis rate was 8.3% (55/661). Lymph node metastasis independently associated with cause-specific survival only when no stratification according to adjuvant treatment was applied (P= 0.035). After stratification according to adjuvant radiotherapy, lymph node status marginally associated with cause-specific survival (P =0.073), whereas myometrial invasion retained its strong association with cause-specific survival (P< 0.001). However, there was no significant difference in the performance of the survival model using only uterine factors and the model using lymph node status and uterine factors (concordance index, 0.77 vs 0.77, respectively;P= 0.798).ConclusionsKnowledge of lymph node status did not significantly improve the performance of survival prediction in apparently uterine-confined endometrial cancer, although it was independently associated with survival. In the patients with clinically early-stage endometrial cancer, the accuracy of the prediction of survival was comparable between risk grouping without lymph node status and that including lymph node status.

Steroid Hormone Receptor Content and Lymph Node Status in Endometrial Cancer

1995 ◽  
Vol 56 (3) ◽  
pp. 406-411 ◽  
Author(s):  
Peter C. Morris ◽  
James R. Anderson ◽  
Barrie Anderson ◽  
Richard E. Buller
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Hormone Receptor ◽  
Steroid Hormone ◽  
Lymph Node Status ◽  
Steroid Hormone Receptor ◽  
Node Status

scholarly journals Identification of microRNA expression profile related to lymph node status in women with early-stage grade 1–2 endometrial cancer

2016 ◽  
Vol 29 (4) ◽  
pp. 391-401 ◽  
Author(s):  
Geoffroy Canlorbe ◽  
Zhe Wang ◽  
Enora Laas ◽  
Sofiane Bendifallah ◽  
Mathieu Castela ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Expression Profile ◽  
Early Stage ◽  
Microrna Expression ◽  
Lymph Node Status ◽  
Microrna Expression Profile ◽  
Node Status

scholarly journals Ultrasound Measurement of Tumor-Free Distance from the Serosal Surface as the Alternative to Measuring the Depth of Myometrial Invasion in Predicting Lymph Node Metastases in Endometrial Cancer

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1472
Author(s):  
Marcin Liro ◽  
Marcin Śniadecki ◽  
Ewa Wycinka ◽  
Szymon Wojtylak ◽  
Michał Brzeziński ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Transvaginal Ultrasound ◽  
Multivariable Analysis ◽  
Myometrial Invasion ◽  
Ultrasound Measurement ◽  
Lymph Node Status ◽  
Free Distance ◽  
Node Metastases

Background: Ultrasonography’s usefulness in endometrial cancer (EC) diagnosis consists in its roles in staging and prediction of metastasis. Ultrasound-measured tumor-free distance from the tumor to the uterine serosa (uTFD) is a promising marker for these diagnostic and prognostic variables. The aim of the study was to determine the usefulness of this biomarker in locoregional staging, and thus in the prediction of lymph node metastasis (LNM). Methods: We conducted a single-institutional, prospective study on 116 consecutive patients with EC who underwent 2D transvaginal ultrasound examination. The uTFD marker was compared with the depth of ultrasound-measured myometrial invasion (uMI). Univariable and multivariable logit models were evaluated to assess the predictive power of the uTFD and uMI in regard to LNM. The reference standard was a final histopathology result. Survival was assessed by the Kaplan–Meier method. Results: LNM was found in 17% of the patients (20/116). In the univariable analysis, uMI and uTFD were significant predictors of LNM. The accuracy was 70.7%, and the NPV was 92.68% (OR 4.746, 95% CI 1.710–13.174) for uMI (p = 0.002), and they were 63.8% and 89.02% (OR 0.842, 95% CI 0.736–0.963), respectively, for uTFD (p = 0.01). The cutoff value for uTFD in the prediction of LNM was 5.2 mm. The association between absence of LNM and biomarker values of uMI < 1/2 and uTFD ≥ 5.2 mm was greater than that between the presence of metastases and uMI > 1/2 and uTFD values <5.2 mm. In the multivariable analysis, the accuracy of the uMI–uTFD model was 74%, and its NPV was 90.24% (p = non-significant). Neither uMI nor uTFD were surrogates for overall and recurrence-free survivals in endometrial cancer. Conclusions: Both uMI and uTFD, either alone or in combination, were valuable tools for gaining additional preoperative information on expected lymph node status. Negative lymph nodes status was better described by ultrasound biomarkers than a positive status. It was easier to use the uTFD rather than the uMI measurement as a biomarker of EC invasion, and the former still maintained a similar predictive value for lymph node metastases to the latter at diagnosis.

Pelvic sentinel lymph node status and risk of aortic nodal metastasis in patients with endometrial cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 5597-5597
Author(s):  
Robert W. Holloway ◽  
Jeffrey A. James ◽  
Corinne N. Jeppson ◽  
Ajit Gubbi ◽  
Erica L. Takimoto ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Nodal Metastasis ◽  
Lymph Node Status ◽  
Node Status ◽  
Sentinel Lymph Node Status

scholarly journals 6P The importance of biomarker expression in addition to lymph node status in the ESMO risk stratification of endometrial cancer

2020 ◽  
Vol 31 ◽  
pp. S1218-S1219
Author(s):  
S. Vrede ◽  
W.J. Van Weelden ◽  
N. Visser ◽  
L.V.D. Putten ◽  
K.V.D. Vijver ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Risk Stratification ◽  
Lymph Node Status ◽  
Node Status
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