scholarly journals Identification of microRNA expression profile related to lymph node status in women with early-stage grade 1–2 endometrial cancer

2016 ◽  
Vol 29 (4) ◽  
pp. 391-401 ◽  
Author(s):  
Geoffroy Canlorbe ◽  
Zhe Wang ◽  
Enora Laas ◽  
Sofiane Bendifallah ◽  
Mathieu Castela ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Expression Profile ◽  
Early Stage ◽  
Microrna Expression ◽  
Lymph Node Status ◽  
Microrna Expression Profile ◽  
Node Status

Lymph Node Status Did Not Significantly Improve the Predictability of Survival in Patients With Clinically Early-Stage Endometrial Cancer

2014 ◽  
Vol 24 (8) ◽  
pp. 1449-1454
Author(s):  
Hyo Sook Bae ◽  
Jong-Min Lee ◽  
Jae-Kwan Lee ◽  
Jae-Weon Kim ◽  
Chi-Heum Cho ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Early Stage ◽  
Lymph Node Status ◽  
Survival Prediction ◽  
Concordance Index ◽  
Node Metastasis ◽  
Node Status ◽  
Early Stage Endometrial Cancer ◽  
Cause Specific Survival

ObjectiveThe aim of this study was to determine whether knowledge of lymph node status improves survival prediction in clinically early-stage endometrial cancer.MethodsThe records of 661 patients with apparently uterine-confined disease were reviewed. The performance in predicting overall survival and cause-specific survival was compared between a multivariate prognostic model with nodal status and a model without nodal status by calculating Harrell concordance index.ResultsAmong 661 patients with clinically early-stage endometrial cancer, the lymph node metastasis rate was 8.3% (55/661). Lymph node metastasis independently associated with cause-specific survival only when no stratification according to adjuvant treatment was applied (P= 0.035). After stratification according to adjuvant radiotherapy, lymph node status marginally associated with cause-specific survival (P =0.073), whereas myometrial invasion retained its strong association with cause-specific survival (P< 0.001). However, there was no significant difference in the performance of the survival model using only uterine factors and the model using lymph node status and uterine factors (concordance index, 0.77 vs 0.77, respectively;P= 0.798).ConclusionsKnowledge of lymph node status did not significantly improve the performance of survival prediction in apparently uterine-confined endometrial cancer, although it was independently associated with survival. In the patients with clinically early-stage endometrial cancer, the accuracy of the prediction of survival was comparable between risk grouping without lymph node status and that including lymph node status.

scholarly journals A systematic review of tests for lymph node status in primary endometrial cancer

2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Tara J Selman ◽  
Christopher H Mann ◽  
Javier Zamora ◽  
Khalid S Khan
Keyword(s):  
Systematic Review ◽  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Status ◽  
Node Status

scholarly journals Challenges Posed by Embryonic and Anatomical Factors in Systematic Lymphadenectomy for Endometrial Cancer

2020 ◽  
Vol 9 (12) ◽  
pp. 4107
Author(s):  
Damaris Freytag ◽  
Julian Pape ◽  
Juhi Dhanawat ◽  
Veronika Günther ◽  
Nicolai Maass ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Surgical Staging ◽  
Current Evidence ◽  
Lymph Node Status ◽  
Prognostic Information ◽  
Systematic Lymphadenectomy ◽  
Lymph Node Mapping ◽  
Node Status ◽  
Wide Range

Lymph node involvement has been shown to be one of the most relevant prognostic factors in a variety of malignancies; this is also true of endometrial cancer. The determination of the lymph node status is crucial in order to establish the tumor stage, and to consider adjuvant treatment. A wide range of surgical staging practices are currently used for the treatment of endometrial cancer. The necessity and extent of lymph node dissection is an ongoing controversial issue in gynecological oncology. Lymph node surgery in endometrial cancer is technically challenging, and can be time consuming because of the topographic complexity of lymphatic drainage as such, and the fact that the lymph nodes are directly adjacent to both blood vessels and nerves. Therefore, profound and exact knowledge of the anatomy is essential. Sentinel lymph node mapping was recently introduced in surgical staging with the aim of reducing morbidity, whilst also obtaining useful prognostic information from a patient’s lymph node status. The present review summarizes the current evidence on the role of lymph node surgery in endometrial cancer, focusing on the embryological, anatomical, and technical aspects.

Relationship of lymph node status with survival and recurrence among women with endometrial cancer

2020 ◽  
Vol 151 (2) ◽  
pp. 267-271
Author(s):  
Osman Cagin Buldukoglu ◽  
Alev Turker ◽  
Alp Usubutun ◽  
Mehmet Coskun Salman
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Status ◽  
Node Status ◽  
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