scholarly journals Changes in the use of psychotropic drugs during the course of Alzheimer's disease: A large‐scale longitudinal study of French medical records

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Manon Ansart ◽  
Stéphane Epelbaum ◽  
Marion Houot ◽  
Thomas Nedelec ◽  
Béranger Lekens ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Psychotropic Drugs ◽  
Medical Records ◽  
Large Scale

Psychotropic Drugs in Patients With Alzheimer's Disease: A Longitudinal Study by the Registry of Dementias of Girona (ReDeGi) in Catalonia, Spain

2014 ◽  
Vol 15 (7) ◽  
pp. 497-503 ◽  
Author(s):  
Laia Calvó-Perxas ◽  
Oriol Turró-Garriga ◽  
Maria Aguirregomozcorta ◽  
Josep Bisbe ◽  
Erélido Hernández ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Psychotropic Drugs

Dehydroepiandrosterone (DHEA) and its Sulphate (DHEAS) in Alzheimer’s Disease

2020 ◽  
Vol 17 (2) ◽  
pp. 141-157 ◽  
Author(s):  
Dubravka S. Strac ◽  
Marcela Konjevod ◽  
Matea N. Perkovic ◽  
Lucija Tudor ◽  
Gordana N. Erjavec ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Large Scale ◽  
Therapeutic Potential ◽  
Relevant Literature ◽  
Comprehensive Overview ◽  
Brain Functions ◽  
Specific Effects ◽  
And Behavior

Background: Neurosteroids Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone Sulphate (DHEAS) are involved in many important brain functions, including neuronal plasticity and survival, cognition and behavior, demonstrating preventive and therapeutic potential in different neuropsychiatric and neurodegenerative disorders, including Alzheimer’s disease. Objective: The aim of the article was to provide a comprehensive overview of the literature on the involvement of DHEA and DHEAS in Alzheimer’s disease. Method: PubMed and MEDLINE databases were searched for relevant literature. The articles were selected considering their titles and abstracts. In the selected full texts, lists of references were searched manually for additional articles. Results: We performed a systematic review of the studies investigating the role of DHEA and DHEAS in various in vitro and animal models, as well as in patients with Alzheimer’s disease, and provided a comprehensive discussion on their potential preventive and therapeutic applications. Conclusion: Despite mixed results, the findings of various preclinical studies are generally supportive of the involvement of DHEA and DHEAS in the pathophysiology of Alzheimer’s disease, showing some promise for potential benefits of these neurosteroids in the prevention and treatment. However, so far small clinical trials brought little evidence to support their therapy in AD. Therefore, large-scale human studies are needed to elucidate the specific effects of DHEA and DHEAS and their mechanisms of action, prior to their applications in clinical practice.

Structural Changes in Thalamic Nuclei Across Prodromal and Clinical Alzheimer’s Disease

2021 ◽  
pp. 1-11
Author(s):  
Adam S. Bernstein ◽  
Steven Z. Rapcsak ◽  
Michael Hornberger ◽  
Manojkumar Saranathan ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Large Scale ◽  
Structural Changes ◽  
Thalamic Nuclei ◽  
Medial Temporal Lobes ◽  
Cognitive Changes ◽  
Temporal Lobes ◽  
Medial Geniculate ◽  
Healthy Control

Background: Increasing evidence suggests that thalamic nuclei may atrophy in Alzheimer’s disease (AD). We hypothesized that there will be significant atrophy of limbic thalamic nuclei associated with declining memory and cognition across the AD continuum. Objective: The objective of this work was to characterize volume differences in thalamic nuclei in subjects with early and late mild cognitive impairment (MCI) as well as AD when compared to healthy control (HC) subjects using a novel MRI-based thalamic segmentation technique (THOMAS). Methods: MPRAGE data from the ADNI database were used in this study (n = 540). Healthy control (n = 125), early MCI (n = 212), late MCI (n = 114), and AD subjects (n = 89) were selected, and their MRI data were parcellated to determine the volumes of 11 thalamic nuclei for each subject. Volumes across the different clinical subgroups were compared using ANCOVA. Results: There were significant differences in thalamic nuclei volumes between HC, late MCI, and AD subjects. The anteroventral, mediodorsal, pulvinar, medial geniculate, and centromedian nuclei were significantly smaller in subjects with late MCI and AD when compared to HC subjects. Furthermore, the mediodorsal, pulvinar, and medial geniculate nuclei were significantly smaller in early MCI when compared to HC subjects. Conclusion: This work highlights nucleus specific atrophy within the thalamus in subjects with early and late MCI and AD. This is consistent with the hypothesis that memory and cognitive changes in AD are mediated by damage to a large-scale integrated neural network that extends beyond the medial temporal lobes.

A longitudinal study of measures of walking in people with Alzheimer's Disease

2010 ◽  
Vol 32 (1) ◽  
pp. 113-117 ◽  
Author(s):  
Joanne E. Wittwer ◽  
Kate E. Webster ◽  
Hylton B. Menz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study

Piano playing in Alzheimer's disease: Longitudinal study of a single case

Neurocase ◽  
1999 ◽  
Vol 5 (5) ◽  
pp. 459-469 ◽  
Author(s):  
William W. Beatty ◽  
Clara L. Rogers ◽  
Rubin L. Rogers ◽  
Shelley English ◽  
Julie A. Testa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Single Case ◽  
Piano Playing

Apolipoprotein E Phenotype Alone Does Not Influence Survival in Alzheimer’s Disease: A Population-Based Longitudinal Study

2000 ◽  
Vol 19 (6) ◽  
pp. 327-332 ◽  
Author(s):  
Anne M. Koivisto ◽  
Päivi Lempiäinen ◽  
Keijo Koivisto ◽  
Eeva-Liisa Helkala ◽  
Leena Mykkänen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Apolipoprotein E ◽  
Population Based

O3-09-01: EXTRACELLULAR VESICLE-BASED BIOMARKERS FOR ALZHEIMER'S DISEASE IN THE BALTIMORE LONGITUDINAL STUDY OF AGING

2006 ◽  
Vol 14 (7S_Part_19) ◽  
pp. P1036-P1036
Author(s):  
Maja Mustapic ◽  
Erez Eitan ◽  
Sean T. Berkowitz ◽  
Thomas C. Diehl ◽  
Seema Gulyani ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Extracellular Vesicle ◽  
Baltimore Longitudinal Study
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