Apolipoprotein E Phenotype Alone Does Not Influence Survival in Alzheimer’s Disease: A Population-Based Longitudinal Study

2000 ◽  
Vol 19 (6) ◽  
pp. 327-332 ◽  
Author(s):  
Anne M. Koivisto ◽  
Päivi Lempiäinen ◽  
Keijo Koivisto ◽  
Eeva-Liisa Helkala ◽  
Leena Mykkänen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Apolipoprotein E ◽  
Population Based

Apolipoprotein E allele 4 is not a sufficient or a necessary predictor of the development of Mild Cognitive Impairment

2010 ◽  
Vol 25 (1) ◽  
pp. 15-18 ◽  
Author(s):  
R. Heun ◽  
U. Gühne ◽  
T. Luck ◽  
M.C. Angermeyer ◽  
U. Ueberham ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Target Population ◽  
Population Based ◽  
Initial Development ◽  
Apoe Ε4 ◽  
Ε4 Allele

AbstractThe presence of Mild Cognitive Impairment (MCI) and of an apolipoprotein E (apoE) ε4 allele both predict the development of Alzheimer's disease. However, the extent to which this allele also predicts the development of MCI is unclear even though MCI is an early transitional stage in the development of Alzheimer's disease. The present study investigates the prevalence of the apoE ε4 allele in incipient MCI. Participants were recruited from the population-based Leipzig Longitudinal Study of the Aged (LEILA75+). All subjects who were initially cognitively healthy, i.e. did not meet MCI criteria described by Petersen [Petersen RC. Mild cognitive impairment. J Intern Med 2004; 256(3): 183–94], and whose apoE status could be determined were followed-up. After 4.5 years, 15.5% of the cognitively healthy target population had developed MCI. The frequencies of the apoE ε4 genotype did not differ between individuals with incipient MCI (12.9%) and individuals who remained cognitively healthy during the study (18.4%, p > 0.5). Consequently, the apoE ε4 genotype is not a necessary or sufficient risk factor for MCI. Further studies need to investigate the influence of the whole range of genetic and environmental risk factors on the course of Alzheimer's disease including the initial development of MCI and the later conversion to Alzheimer's disease.

Familial and Population-Based Studies of Apolipoprotein E and Alzheimer's Disease

1996 ◽  
Vol 802 (1 Apolipoprotei) ◽  
pp. 16-26 ◽  
Author(s):  
MICHAEL MULLAN ◽  
PAUL SCIBELLI ◽  
RANJAN DUARA ◽  
DANIELLE FALLIN ◽  
MICHAEL GOLD ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Population Based

scholarly journals Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada

2001 ◽  
Vol 30 (3) ◽  
pp. 590-597 ◽  
Author(s):  
Suzanne L Tyas ◽  
Jure Manfreda ◽  
Laurel A Strain ◽  
Patrick R Montgomery
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Longitudinal Study ◽  
Population Based

A Population Study of Alzheimer’s Disease: Findings From the Cache County Study on Memory, Health, and Aging

2005 ◽  
Vol 6 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Joann T. Tschanz ◽  
Katherine Treiber ◽  
Maria C. Norton ◽  
Kathleen A. Welsh-Bohmer ◽  
Leslie Toone ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Oldest Old ◽  
Population Based ◽  
Apolipoprotein E Gene ◽  
Initial Cohort ◽  
Males And Females ◽  
Cache County

There are several population-based studies of aging, memory, and dementia being conducted worldwide. Of these, the Cache County Study on Memory, Health and Aging is noteworthy for its large number of “oldest-old” members. This study, which has been following an initial cohort of 5,092 seniors since 1995, has reported among its major findings the role of the Apolipoprotein E gene on modifying the risk for Alzheimer’s disease (AD) in males and females and identifying pharmacologic compounds that may act to reduce AD risk. This article summarizes the major findings of the Cache County study to date, describes ongoing investigations, and reports preliminary analyses on the outcome of the oldest-old in this population, the subgroup of participants who were over age 84 at the study’s inception.

scholarly journals Shared risk and protective factors between Alzheimer's disease and ischemic stroke: A population‐based longitudinal study

2021 ◽  
Vol 17 (2) ◽  
pp. 191-204
Author(s):  
Rui Wang ◽  
Chengxuan Qiu ◽  
Christina S. Dintica ◽  
Ying Shang ◽  
Amaia Calderón Larrañaga ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ischemic Stroke ◽  
Longitudinal Study ◽  
Protective Factors ◽  
Risk And Protective Factors ◽  
Population Based ◽  
Shared Risk

Longitudinal study of cerebrospinal fluid amyloid proteins and apolipoprotein E in patients with probable Alzheimer's disease

1998 ◽  
Vol 249 (1) ◽  
pp. 21-24 ◽  
Author(s):  
Tuula Pirttilä ◽  
Keijo Koivisto ◽  
Pankaj D Mehta ◽  
Kari Reinikainen ◽  
Kwang S Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Longitudinal Study ◽  
Apolipoprotein E ◽  
Amyloid Proteins

scholarly journals Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study

BMJ ◽  
1994 ◽  
Vol 309 (6955) ◽  
pp. 636-638 ◽  
Author(s):  
J Kuusisto ◽  
K Koivisto ◽  
K Kervinen ◽  
L Mykkanen ◽  
E-L Helkala ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Late Onset ◽  
Population Based ◽  
Population Based Study
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