Subacute toxicity of chlorpyrifos on histopathological damages, antioxidant activity, and pro‐inflammatory cytokines in the rat model

2022 ◽  
Author(s):  
Hiva Alipanah ◽  
Hashmieh Kabi Doraghi ◽  
Mehran Sayadi ◽  
Amene Nematollahi ◽  
Ava Soltani Hekmat ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Inflammatory Cytokines ◽  
Rat Model ◽  
Subacute Toxicity ◽  
Pro Inflammatory Cytokines

Mitigation of IL-1β, IL-6, TNF-α, and markers of apoptosis by ursolic acid against cisplatin-induced oxidative stress and nephrotoxicity in rats

2021 ◽  
Vol 40 (12_suppl) ◽  
pp. S397-S405
Author(s):  
Pankaj Tripathi ◽  
Saeed Alshahrani
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Uric Acid ◽  
Inflammatory Cytokines ◽  
Caspase 3 ◽  
Caspase 9 ◽  
Histological Damage ◽  
Tnf Α ◽  
Mda Content ◽  
Pro Inflammatory Cytokines

Background: Ursolic acid (UA) is a natural pentacyclic triterpenoid that is known for its benefits under several pathological conditions. Cisplatin (CP) is among the most preferred chemotherapeutic agents; however, its nephrotoxicity limits its clinical utility. Purpose: This study was aimed to determine the role of UA in the reduction of CP-induced nephrotoxicity and mitigation of pro-inflammatory cytokines and apoptosis in a rat model. Methodology: Male Wistar rats were randomized into vehicle control, CP (7.5 mg/kg), UA 10 mg/kg, and CP with UA 5 and 10 mg/kg groups. Kidney and blood samples were collected for assessment of renal function, measurement of pro-inflammatory cytokines, apoptosis markers, antioxidant activity, and tissue histology. Results: CP significantly increased the levels of serum Cr, BUN, and uric acid; it also induced histological damage reflecting the pathophysiology observed during nephrotoxicity. CP has also shown its pro-oxidant activity in kidney tissue because CP decreased the levels of GSH, SOD, and CAT; it increased the lipid peroxidation as measured by MDA content. In addition, CP significantly upregulated the activity of pro-inflammatory cytokines and expression of apoptotic markers, that is, there were increased levels of IL-1β, IL-6, TNF-α, caspase-3, and caspase-9. Two weeks of continuous treatment of UA showed significant recovery against CP-induced nephrotoxicity; UA decreased the levels of Cr, BUN, and uric acid and ameliorated histological damage. UA also downregulated the activities of IL-1β, IL-6, and TNF-α as well as expression of caspase-3 and caspase-9. Furthermore, CP-induced oxidative stress that was antagonized by UA—the levels of GSH, SOD, and CAT were significantly increased while MDA content was decreased. Conclusions: UA has a protective effect against CP-induced nephrotoxicity, which may be due to its antioxidant activity and mitigation of ILβ-1, ILβ-6, TNF-α, and markers of apoptosis.

Escitalopram reduces circulating pro-inflammatory cytokines and improves depressive behavior without affecting sleep in a rat model of post-cardiac infarct depression

2011 ◽  
Vol 225 (1) ◽  
pp. 243-251 ◽  
Author(s):  
Thierno Madjou Bah ◽  
Mohamed Benderdour ◽  
Sévan Kaloustian ◽  
Ramy Karam ◽  
Guy Rousseau ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Rat Model ◽  
Depressive Behavior ◽  
Pro Inflammatory Cytokines

scholarly journals Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

10.3791/57879 ◽  
2021 ◽  
Author(s):  
Muammer Üçal ◽  
Michaela Tanja Haindl ◽  
Milena Z. Adzemovic ◽  
Manuel Zeitelhofer ◽  
Ute Schaefer ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Rat Model ◽  
Intracerebral Injection ◽  
Pro Inflammatory Cytokines
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