miR ‐141‐3p regulates saturated fatty acid‐induced cardiomyocyte apoptosis through Notch1/ PTEN / AKT pathway via targeting PSEN1

2021 ◽  
Author(s):  
Xin Xin ◽  
Lian Duan ◽  
Huimin Yang ◽  
Hang Yu ◽  
Yandong Bao ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
Cardiomyocyte Apoptosis ◽  
Akt Pathway

scholarly journals p38α MAPK mediates saturated fatty acid‐induced cardiomyocyte apoptosis (547.19)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Charles Oh ◽  
Michael Nguy ◽  
Raymond Migrino ◽  
Kent Thornburg ◽  
Dawn Schwenke ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
Cardiomyocyte Apoptosis ◽  
P38α Mapk

Saturated fatty acid-induced insulin resistance in rat adipocytes

Diabetes ◽  
1994 ◽  
Vol 43 (4) ◽  
pp. 540-545 ◽  
Author(s):  
J. W. Hunnicutt ◽  
R. W. Hardy ◽  
J. Williford ◽  
J. M. McDonald
Keyword(s):  
Insulin Resistance ◽  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
Rat Adipocytes

scholarly journals THE SATURATED FATTY ACID OF KEPHALIN

1914 ◽  
Vol 16 (4) ◽  
pp. 419-422
Author(s):  
P.A. Levene ◽  
C.J. West
Keyword(s):  
Fatty Acid ◽  
Saturated Fatty Acid

Association between meat and saturated fatty acid intake and lung cancer risk: The Japan Public Health Center‐based prospective study

2020 ◽  
Vol 147 (11) ◽  
pp. 3019-3028
Author(s):  
Honglin Cai ◽  
Tomotaka Sobue ◽  
Tetsuhisa Kitamura ◽  
Junko Ishihara ◽  
Norie Sawada ◽  
...  
Keyword(s):  
Public Health ◽  
Lung Cancer ◽  
Fatty Acid ◽  
Cancer Risk ◽  
Prospective Study ◽  
Health Center ◽  
Saturated Fatty Acid ◽  
Lung Cancer Risk ◽  
Fatty Acid Intake ◽  
Public Health Center

ChemInform Abstract: Synthesis of Scyphostatin Analogues Possessing Various Saturated Fatty Acid Side-Chains.

ChemInform ◽  
2008 ◽  
Vol 39 (19) ◽  
Author(s):  
Kazuhiro Watanabe ◽  
Takamasa Oguchi ◽  
Toshiya Takizawa ◽  
Miki Furuuchi ◽  
Hideki Abe ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
Side Chains

scholarly journals Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes

2012 ◽  
Vol 56 (1) ◽  
pp. 192-198 ◽  
Author(s):  
Manju Sharma ◽  
Fumihiko Urano ◽  
Anja Jaeschke
Keyword(s):  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
Jnk Pathway

Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs)-Exosome Carrying MiRNA-312 Inhibits Sevoflurane-Induced Cardiomyocyte Apoptosis Through Activation of Phosphatidylinositol 3-Kinase/Protein Kinase B (PI3K/AKT) Pathway

2022 ◽  
Vol 12 (5) ◽  
pp. 947-952
Author(s):  
Jun Zhang ◽  
Yuying Gao ◽  
Peng Chen ◽  
Yu Zhou ◽  
Sheng Guo ◽  
...  
Keyword(s):  
Protein Kinase B ◽  
Cardiomyocyte Apoptosis ◽  
Erk Signaling ◽  
Akt Pathway ◽  
Cardiomyocyte Proliferation ◽  
Akt Signaling Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Dmso Treatment ◽  
Induced Apoptosis ◽  
Related Proteins

This study was to explore the mechanism by how exosomes (exo) derived from BMSCs affects cardiomyocyte apoptosis. BMSCs were isolated and incubated with cardiomyocytes while the cardiomyocytes were exposed to sevoflurane or DMSO treatment. Apoptotic cells were calculated and level of apoptosis related proteins was detected by Western blot. Through transfection with microRNA-(miRNA)-312 inhibitor, we evaluated the effect of BMSC-exo on the sevoflurane-induced apoptosis. Sevoflurane significantly inhibited the viability of cardiomyocytes and induced cardiomyocyte apoptosis. Besides, sevoflurane decreased the expression of miR-312 and enhanced Bax expression in cardiomyocytes through restraining the phosphorylation of MAPK/ERK. Treatment with BMSC-exo, however, activated MAPK/ERK signaling by up-regulating miR-312, thereby inhibiting cardiomyocyte apoptosis, promoting cardiomyocyte proliferation, and elevating the level of Bcl-2. In conclusion, BMSC-exo-derived miR-312 inhibits sevoflurane-induced cardiomyocyte apoptosis by activating PI3K/AKT signaling pathway.

High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis

2017 ◽  
Vol 138 ◽  
pp. 140-149 ◽  
Author(s):  
Seung-Hee Lee ◽  
Daniel Cunha ◽  
Carlo Piermarocchi ◽  
Giovanni Paternostro ◽  
Anthony Pinkerton ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
High Throughput ◽  
Cell Apoptosis ◽  
High Throughput Screening ◽  
Bioinformatic Analysis ◽  
Β Cell
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