Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation

2021 ◽  
Author(s):  
Yuan Hu ◽  
Pengchuang Zhang ◽  
Yu Shi ◽  
Xuyuan Dong ◽  
Yinying Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Antitumor Effects ◽  
Ras Protein ◽  
Protein Activator

S2003 Decreased Expression of RAS Protein Activator Like 1 in Gastric Cancer

2009 ◽  
Vol 136 (5) ◽  
pp. A-311
Author(s):  
Motoko Seto ◽  
Miki Ohta ◽  
Motohisa Tada ◽  
Koji Miyabayashi ◽  
Dai Mohri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Ras Protein ◽  
Protein Activator

Reduced expression of RAS protein activator like-1 in gastric cancer

2011 ◽  
Vol 128 (6) ◽  
pp. 1293-1302 ◽  
Author(s):  
Motoko Seto ◽  
Miki Ohta ◽  
Tsuneo Ikenoue ◽  
Takafumi Sugimoto ◽  
Yoshinari Asaoka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Ras Protein ◽  
Protein Activator

scholarly journals Evaluation of the Antitumor Effects and Mechanisms of PF00299804, a Pan-HER Inhibitor, Alone or in Combination with Chemotherapy or Targeted Agents in Gastric Cancer

2011 ◽  
Vol 11 (2) ◽  
pp. 439-451 ◽  
Author(s):  
Hyun-Jin Nam ◽  
Keith A. Ching ◽  
Julie Kan ◽  
Hwang-Phill Kim ◽  
Sae-Won Han ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Targeted Agents ◽  
Antitumor Effects

scholarly journals Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (46) ◽  
pp. 76076-76086 ◽  
Author(s):  
Junxiong Wang ◽  
Shuo Yang ◽  
Xiqiang Cai ◽  
Jiaqiang Dong ◽  
Zhangqian Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Egfr Inhibitors ◽  
Egfr Signaling ◽  
Antitumor Effects

scholarly journals Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Wenjing Shang ◽  
Zhongdong Xie ◽  
Fengying Lu ◽  
Daoquan Fang ◽  
Tianbin Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Poor Prognosis ◽  
Prognostic Significance ◽  
Migration And Invasion ◽  
Human Gastric Cancer ◽  
Antitumor Effects ◽  
Thioredoxin 1

Background. Thioredoxin-1 (Trx-1) is a small redox protein, which plays an important role in many biological processes. Although increased expression of Trx-1 in various solid tumors has been reported, the prognostic significance and function of Trx-1 in human gastric cancer (GC) are still unclear. Here, we investigated the clinical and prognostic significance of Trx-1 expression and the function and mechanism of Trx-1 in human GC. Methods. We analyzed Trx-1 mRNA expression from the GEO database and Trx-1 protein expression in 144 GC tissues using immunohistochemistry. Effects of Trx-1 on GC cell were assessed in vitro and in vivo through Trx-1 knockdown or overexpression. The antitumor effects of the Trx-1 inhibitor, PX-12, on GC cells were investigated. PTEN and p-AKT expressions were evaluated by Western blotting. Results. Increased Trx-1 expression was found in GC tissues and associated with poor prognosis and aggressive clinicopathological characteristics in patients with GC. High Trx-1 expression predicted poor prognosis, and its expression was an independent prognostic factor for overall survival of GC patients. Knockdown of Trx-1 expression inhibited GC cell growth, migration, and invasion in vitro and tumor growth and lung metastasis in vivo. Conversely, overexpression of Trx-1 promoted GC cell growth, migration, and invasion. We also found that PX-12 inhibited GC cell growth, migration, and invasion. Overexpression of Trx-1 caused a decrease in PTEN and increase in p-AKT levels whereas silencing Trx-1 caused an increase in PTEN and decrease in p-AKT levels in GC cells. Inhibition of AKT signaling pathway by MK2206 also inhibited GC cell growth, migration, and invasion. Conclusion. Our results indicate that Trx-1 may be a promising prognostic indicator and therapeutic target for GC patients.

scholarly journals Sodium Selenite Accentuates the Therapeutic Effect of Adriamycin Prodrug (PADM) against Gastric Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Shengquan Tan ◽  
Jiapeng Mo ◽  
Zixiong Zhang ◽  
Chuying Huang ◽  
Yi Zou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Sodium Selenite ◽  
Therapeutic Potential ◽  
Mitochondrial Fission ◽  
Combined Treatment ◽  
Mitochondrial Morphology ◽  
Gastric Cancer Cells ◽  
Antitumor Effects ◽  
And Migration

Selenium has remained a controversial character in cancer research. While its antitumor effects have been widely demonstrated, further evidence is required to establish it as a robust treatment regime. Sodium selenite (SS), an inorganic selenium, reportedly affected the proliferation and redifferentiation of gastric cancer cells, but whether it could act as a complement to conventional chemotherapeutic drugs for combination therapy is uncertain. Herein, SGC-7901 and MGC-803 gastric cancer cells were treated with PADM (Ac-Phe-Lys-PABC-ADM), a prodrug of doxorubicin/adriamycin (ADM), and the combined antitumor effects of the two drugs were evaluated. Characterization after treatment revealed that although PADM exhibited antitumor effects individually by inhibiting the proliferation and migration of gastric cancer cells and inducing apoptosis, the addition of SS significantly amplified these effects. Furthermore, gastric cancer cell apoptosis triggered by the combined treatment of SS and PADM may involve the participation of mitochondrial apoptosis, as evidenced by the changes in mitochondrial morphology and occurrence of mitochondrial fission. Collectively, SS could be a strong complementary drug that accentuates the therapeutic potential of PADM in gastric cancer treatment and management, and its significance could contribute to unique and innovative anticancer strategies.

Abstract 2539: Antitumor effects of oral paclitaxel DHP107 on gastric cancer xenografts

2011 ◽  
Author(s):  
Young-Soon Na ◽  
Kyung-Ah Jung ◽  
Soo-Jin Yang ◽  
Seung-Mi Kim ◽  
Hye Youn Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Antitumor Effects ◽  
Oral Paclitaxel
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