scholarly journals Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (46) ◽  
pp. 76076-76086 ◽  
Author(s):  
Junxiong Wang ◽  
Shuo Yang ◽  
Xiqiang Cai ◽  
Jiaqiang Dong ◽  
Zhangqian Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Egfr Inhibitors ◽  
Egfr Signaling ◽  
Antitumor Effects

scholarly journals Evaluation of the Antitumor Effects and Mechanisms of PF00299804, a Pan-HER Inhibitor, Alone or in Combination with Chemotherapy or Targeted Agents in Gastric Cancer

2011 ◽  
Vol 11 (2) ◽  
pp. 439-451 ◽  
Author(s):  
Hyun-Jin Nam ◽  
Keith A. Ching ◽  
Julie Kan ◽  
Hwang-Phill Kim ◽  
Sae-Won Han ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Targeted Agents ◽  
Antitumor Effects

Tu1606 Galectin-3 Regulates Gastric Cancer Cell Proliferation Through EGFR Signaling Pathway.

2013 ◽  
Vol 144 (5) ◽  
pp. S-804
Author(s):  
Nobuko Serizawa ◽  
Akihito Nagahara ◽  
Shunhei Yamashina ◽  
Gentaro Taniguchi ◽  
Sumio Watanabe
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Egfr Signaling ◽  
Egfr Signaling Pathway ◽  
Galectin 3 ◽  
Gastric Cancer Cell Proliferation

scholarly journals Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Wenjing Shang ◽  
Zhongdong Xie ◽  
Fengying Lu ◽  
Daoquan Fang ◽  
Tianbin Tang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Growth ◽  
Poor Prognosis ◽  
Prognostic Significance ◽  
Migration And Invasion ◽  
Human Gastric Cancer ◽  
Antitumor Effects ◽  
Thioredoxin 1

Background. Thioredoxin-1 (Trx-1) is a small redox protein, which plays an important role in many biological processes. Although increased expression of Trx-1 in various solid tumors has been reported, the prognostic significance and function of Trx-1 in human gastric cancer (GC) are still unclear. Here, we investigated the clinical and prognostic significance of Trx-1 expression and the function and mechanism of Trx-1 in human GC. Methods. We analyzed Trx-1 mRNA expression from the GEO database and Trx-1 protein expression in 144 GC tissues using immunohistochemistry. Effects of Trx-1 on GC cell were assessed in vitro and in vivo through Trx-1 knockdown or overexpression. The antitumor effects of the Trx-1 inhibitor, PX-12, on GC cells were investigated. PTEN and p-AKT expressions were evaluated by Western blotting. Results. Increased Trx-1 expression was found in GC tissues and associated with poor prognosis and aggressive clinicopathological characteristics in patients with GC. High Trx-1 expression predicted poor prognosis, and its expression was an independent prognostic factor for overall survival of GC patients. Knockdown of Trx-1 expression inhibited GC cell growth, migration, and invasion in vitro and tumor growth and lung metastasis in vivo. Conversely, overexpression of Trx-1 promoted GC cell growth, migration, and invasion. We also found that PX-12 inhibited GC cell growth, migration, and invasion. Overexpression of Trx-1 caused a decrease in PTEN and increase in p-AKT levels whereas silencing Trx-1 caused an increase in PTEN and decrease in p-AKT levels in GC cells. Inhibition of AKT signaling pathway by MK2206 also inhibited GC cell growth, migration, and invasion. Conclusion. Our results indicate that Trx-1 may be a promising prognostic indicator and therapeutic target for GC patients.

scholarly journals Sodium Selenite Accentuates the Therapeutic Effect of Adriamycin Prodrug (PADM) against Gastric Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Shengquan Tan ◽  
Jiapeng Mo ◽  
Zixiong Zhang ◽  
Chuying Huang ◽  
Yi Zou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Sodium Selenite ◽  
Therapeutic Potential ◽  
Mitochondrial Fission ◽  
Combined Treatment ◽  
Mitochondrial Morphology ◽  
Gastric Cancer Cells ◽  
Antitumor Effects ◽  
And Migration

Selenium has remained a controversial character in cancer research. While its antitumor effects have been widely demonstrated, further evidence is required to establish it as a robust treatment regime. Sodium selenite (SS), an inorganic selenium, reportedly affected the proliferation and redifferentiation of gastric cancer cells, but whether it could act as a complement to conventional chemotherapeutic drugs for combination therapy is uncertain. Herein, SGC-7901 and MGC-803 gastric cancer cells were treated with PADM (Ac-Phe-Lys-PABC-ADM), a prodrug of doxorubicin/adriamycin (ADM), and the combined antitumor effects of the two drugs were evaluated. Characterization after treatment revealed that although PADM exhibited antitumor effects individually by inhibiting the proliferation and migration of gastric cancer cells and inducing apoptosis, the addition of SS significantly amplified these effects. Furthermore, gastric cancer cell apoptosis triggered by the combined treatment of SS and PADM may involve the participation of mitochondrial apoptosis, as evidenced by the changes in mitochondrial morphology and occurrence of mitochondrial fission. Collectively, SS could be a strong complementary drug that accentuates the therapeutic potential of PADM in gastric cancer treatment and management, and its significance could contribute to unique and innovative anticancer strategies.

Abstract 2539: Antitumor effects of oral paclitaxel DHP107 on gastric cancer xenografts

2011 ◽  
Author(s):  
Young-Soon Na ◽  
Kyung-Ah Jung ◽  
Soo-Jin Yang ◽  
Seung-Mi Kim ◽  
Hye Youn Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Antitumor Effects ◽  
Oral Paclitaxel

Abstract 5520: HER2-targeted gold nanoparticles produce potent antitumor effects on human gastric cancer cells

2015 ◽  
Author(s):  
Tetsushi Kubota ◽  
Shinji Kuroda ◽  
Katsuyuki Aoyama ◽  
Hiroshi Tazawa ◽  
Shunsuke Kagawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Antitumor Effects

scholarly journals Antitumor effects of seleno-short-chain chitosan (SSCC) against human gastric cancer BGC-823 cells

2019 ◽  
Vol 71 (6) ◽  
pp. 1095-1108 ◽  
Author(s):  
Xiao-dan Dong ◽  
Juan Yu ◽  
Fan-qi Meng ◽  
Ying-ying Feng ◽  
Hai-yu Ji ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Short Chain ◽  
Human Gastric Cancer ◽  
Antitumor Effects

PLGA nanoparticle-based docetaxel/LY294002 drug delivery system enhances antitumor activities against gastric cancer

2019 ◽  
Vol 33 (10) ◽  
pp. 1394-1406 ◽  
Author(s):  
Juan Cai ◽  
Keyang Qian ◽  
Xueliang Zuo ◽  
Wuheng Yue ◽  
Yinzhu Bian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Drug Delivery ◽  
Controlled Release ◽  
Mouse Model ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Poly Lactic Acid ◽  
Antitumor Effects

Docetaxel (TXT) is acknowledged as one of the most important chemotherapy agents for gastric cancer (GC). PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects. However, the hydrophobicity of TXT and the poor solubility and low bioavailability of LY294002 limit their clinical application. To overcome these shortcomings, we developed poly(lactic acid/glycolic) (PLGA) nanoparticles loaded with TXT and LY294002. PLGA facilitated the accumulation of TXT and LY294002 at the tumor sites. The in vitro functional results showed that PLGA(TXT+LY294002) exhibited controlled-release and resulted in a markedly reduced proliferative capacity and an elevated apoptosis rate. An in vivo orthotopic GC mouse model and xenograft mouse model confirmed the anticancer superiority and tumor-targeting feature of PLGA(TXT+LY294002). Histological analysis indicated that PLGA(TXT+LY294002) was biocompatible and had no toxicity to major organs. Characterized by the combined slow release of TXT and LY294002, this novel PLGA-based TXT/LY294002 drug delivery system provides controlled release and tumor targeting and is safe, shedding light on the future of targeted therapy against GC.

Sign in / Sign up

Export Citation Format

Share Document