Combined lead and zinc oxide‐nanoparticles induced thyroid toxicity through 8‐OHdG oxidative stress‐mediated inflammation, apoptosis, and Nrf2 activation in rats

2021 ◽  
Author(s):  
Eman El‐Sayed Khayal ◽  
Hanaa M. Ibrahim ◽  
Amany Mohamed Shalaby ◽  
Mohamed Ali Alabiad ◽  
Arwa A. El‐Sheikh
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Lead And Zinc ◽  
Nrf2 Activation ◽  
Thyroid Toxicity

Sunscreens containing zinc oxide nanoparticles can trigger oxidative stress and toxicity to the marine copepod Tigriopus japonicus

2020 ◽  
Vol 154 ◽  
pp. 111078 ◽  
Author(s):  
Stella W.Y. Wong ◽  
Guang-Jie Zhou ◽  
Priscilla T.Y. Leung ◽  
Jeonghoon Han ◽  
Jae-Seong Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Tigriopus Japonicus ◽  
Marine Copepod ◽  
Copepod Tigriopus Japonicus

scholarly journals The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing Is Associated with Oxidative Stress In Vitro

Materials ◽  
2019 ◽  
Vol 12 (24) ◽  
pp. 4062
Author(s):  
Till Jasper Meyer ◽  
Agmal Scherzad ◽  
Helena Moratin ◽  
Thomas Eckert Gehrke ◽  
Julian Killisperger ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxidative Dna Damage ◽  
Clonogenic Survival ◽  
Oxide Nanoparticles ◽  
Radiosensitizing Effect ◽  
Primary Fibroblasts

Radioresistance is an important cause of head and neck cancer therapy failure. Zinc oxide nanoparticles (ZnO-NP) mediate tumor-selective toxic effects. The aim of this study was to evaluate the potential for radiosensitization of ZnO-NP. The dose-dependent cytotoxicity of ZnO-NP20 nm and ZnO-NP100 nm was investigated in FaDu and primary fibroblasts (FB) by an MTT assay. The clonogenic survival assay was used to evaluate the effects of ZnO-NP alone and in combination with irradiation on FB and FaDu. A formamidopyrimidine-DNA glycosylase (FPG)-modified single-cell microgel electrophoresis (comet) assay was applied to detect oxidative DNA damage in FB as a function of ZnO-NP and irradiation exposure. A significantly increased cytotoxicity after FaDu exposure to ZnO-NP20 nm or ZnO-NP100 nm was observed in a concentration of 10 µg/mL or 1 µg/mL respectively in 30 µg/mL of ZnO-NP20 nm or 20 µg/mL of ZnO-NP100 nm in FB. The addition of 1, 5, or 10 µg/mL ZnO-NP20 nm or ZnO-NP100 nm significantly reduced the clonogenic survival of FaDu after irradiation. The sub-cytotoxic dosage of ZnO-NP100 nm increased the oxidative DNA damage compared to the irradiated control. This effect was not significant for ZnO-NP20 nm. ZnO-NP showed radiosensitizing properties in the sub-cytotoxic dosage. At least for the ZnO-NP100 nm, an increased level of oxidative stress is a possible mechanism of the radiosensitizing effect.

Acute pulmonary oxidative stress and inflammation caused by zinc oxide nanoparticles were prevented by vitamin C

2014 ◽  
Vol 229 ◽  
pp. S239
Author(s):  
Hiroko Fukui ◽  
Hitoshi Iwahashi ◽  
Shigehisa Endoh ◽  
Keiko Nishio ◽  
Yasukazu Yoshida ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Vitamin C ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals UVB exposure enhanced the dermal penetration of zinc oxide nanoparticles and induced inflammatory responses through oxidative stress mediated by MAPKs and NF-κB signaling in SKH-1 hairless mouse skin

2016 ◽  
Vol 5 (4) ◽  
pp. 1066-1077 ◽  
Author(s):  
Anu Pal ◽  
Shamshad Alam ◽  
Lalit K. S. Chauhan ◽  
Prem N. Saxena ◽  
Mahadeo Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Inflammatory Responses ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Dermal Penetration ◽  
Uvb Exposure

UVB exposure enhances the internalization of ZnO-NPs and caused changes in surface morphology of SKH-1 mouse skin.

scholarly journals Potentials of synthesised Lessertia montana zinc oxide nanoparticles on free radicals-mediated oxidative stress and carbohydrate-hydrolysing enzymes

2021 ◽  
Vol 64 (2) ◽  
pp. 239-249
Author(s):  
Fatai O. Balogun ◽  
Anofi O.T. Ashafa
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Free Radicals ◽  
Zinc Oxide Nanoparticles ◽  
Alpha Amylase ◽  
Oxide Nanoparticles ◽  
Zinc Oxide Nanostructures ◽  
Metal Chelating ◽  
Alpha Glucosidase

The study evaluated the effects of green absorbed zinc oxide nanostructures on oxidative stress-mediated free radicals and carbohydrate-hydrolysing enzymes. The synthesised Lessertia montana zinc oxide nanoparticles were characterised using different spectroscopic, microscopic, and diffraction techniques. The activity of L. montana ZnONPs against 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethyl-benzothiazoline-6-sulfonic acid (ABTS), metal chelating assay, alpha-amylase and alphaglucosidase were determined using standard methods. L. montana ZnONPs were stable nanoparticles (NPs), appeared cubical (predominantly) in shape, and in nanometre range sizes. The synthesised NPs are very active (p < 0.05) against DPPH and alpha-glucosidase (0.120 and 0.037 g/L, respectively) when compared with other samples and controls, quercetin (0.349 g/L) and acarbose (0.065 g/L). However, their interaction with quercetin revealed a good ABTS (0.093 g/L) scavenging and an excellent metal chelating (0.027 g/L) effect compared to other samples. The mode of inhibition of alpha-amylase and alpha-glucosidase enzymes by L. montana ZnONPs was competitive and non-competitive, respectively. The study outcomes revealed that the synthesised ZnONPs possessed the potential to mitigate oxidative stress and diabetes in vitro.

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