Altered hepatic mRNA expression of immune response-associated DNA damage in mice liver induced by potassium bromate: Protective role of vanillin

2015 ◽  
Vol 31 (12) ◽  
pp. 1796-1807 ◽  
Author(s):  
Hajer Ben Saad ◽  
Dorra Driss ◽  
Ibtissem Ben Amara ◽  
Ons Boudawara ◽  
Tahia Boudawara ◽  
...  
Keyword(s):  
Immune Response ◽  
Dna Damage ◽  
Mrna Expression ◽  
Protective Role ◽  
Potassium Bromate ◽  
Mice Liver

scholarly journals The role of unconventional T cells in COVID-19

2021 ◽  
Author(s):  
Kristen Orumaa ◽  
Margaret R. Dunne
Keyword(s):  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Treatment Strategies ◽  
Γδ T Cells ◽  
Protective Role ◽  
T Cell Subsets ◽  
Viral Immunity ◽  
Mait Cells

AbstractCOVID-19 is a respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first documented in late 2019, but within months, a worldwide pandemic was declared due to the easily transmissible nature of the virus. Research to date on the immune response to SARS-CoV-2 has focused largely on conventional B and T lymphocytes. This review examines the emerging role of unconventional T cell subsets, including γδ T cells, invariant natural killer T (iNKT) cells and mucosal associated invariant T (MAIT) cells in human SARS-CoV-2 infection.Some of these T cell subsets have been shown to play protective roles in anti-viral immunity by suppressing viral replication and opsonising virions of SARS-CoV. Here, we explore whether unconventional T cells play a protective role in SARS-CoV-2 infection as well. Unconventional T cells are already under investigation as cell-based immunotherapies for cancer. We discuss the potential use of these cells as therapeutic agents in the COVID-19 setting. Due to the rapidly evolving situation presented by COVID-19, there is an urgent need to understand the pathogenesis of this disease and the mechanisms underlying its immune response. Through this, we may be able to better help those with severe cases and lower the mortality rate by devising more effective vaccines and novel treatment strategies.

scholarly journals Protective role of systemic furin in immune response-induced arthritis

2012 ◽  
Vol 64 (9) ◽  
pp. 2878-2886 ◽  
Author(s):  
Hilène Lin ◽  
Marie-Dominique Ah Kioon ◽  
Claude Lalou ◽  
Jerome Larghero ◽  
Jean-Marie Launay ◽  
...  
Keyword(s):  
Immune Response ◽  
Protective Role

Protective role of thiols in carcinogen-induced DNA damage in rat liver

1986 ◽  
Vol 7 (10) ◽  
pp. 1621-1624 ◽  
Author(s):  
John Y.H. Chan ◽  
Daniel L. Stout ◽  
Frederick F. Becker
Keyword(s):  
Dna Damage ◽  
Rat Liver ◽  
Protective Role

scholarly journals Protective role of Indoleamine 2,3 dioxygenase in Respiratory Syncytial Virus associated immune response in airway epithelial cells

Virology ◽  
2017 ◽  
Vol 512 ◽  
pp. 144-150 ◽  
Author(s):  
Devi Rajan ◽  
Raghavan Chinnadurai ◽  
Evan L. O'Keefe ◽  
Seyhan Boyoglu-Barnum ◽  
Sean O. Todd ◽  
...  
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Epithelial Cells ◽  
Protective Role ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Indoleamine 2,3 Dioxygenase ◽  
Syncytial Virus

Protective role of chrysin on doxorubicin‐induced oxidative stress and DNA damage in rat testes

Andrologia ◽  
2020 ◽  
Vol 52 (9) ◽  
Author(s):  
Saadet Belhan ◽  
Mustafa Özkaraca ◽  
Uğur Özdek ◽  
Ahmet Ufuk Kömüroğlu
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Protective Role

scholarly journals Probiotic antigenotoxic activity as a DNA bioprotective tool: a minireview with focus on endocrine disruptors

2020 ◽  
Vol 367 (3) ◽  
Author(s):  
Natalia Garcia-Gonzalez ◽  
Roberta Prete ◽  
Monia Perugini ◽  
Carmine Merola ◽  
Natalia Battista ◽  
...  
Keyword(s):  
Dna Damage ◽  
Endocrine Disruptors ◽  
Food Packaging ◽  
Estrogenic Activity ◽  
Endocrine System ◽  
Protective Role ◽  
Hormonal Function ◽  
Genotoxic Compounds ◽  
Exogenous Substances

ABSTRACT Nowadays, the interest in the role of dietary components able to influence the composition and the activity of the intestinal microbiota and, consequently, to modulate the risk of genotoxicity and colon cancer is increasing in the scientific community. Within this topic, the microbial ability to have a protective role at gastrointestinal level by counteracting the biological activity of genotoxic compounds, and thus preventing the DNA damage, is deemed important in reducing gut pathologies and is considered a new tool for probiotics and functional foods. A variety of genotoxic compounds can be found in the gut and, besides food-related mutagens and other DNA-reacting compounds, there is a group of pollutants commonly used in food packaging and/or in thousands of everyday products called endocrine disruptors (EDs). EDs are exogenous substances that alter the functions of the endocrine system through estrogenic and anti-estrogenic activity, which interfere with normal hormonal function in human and wildlife. Thus, this paper summarizes the main applications of probiotics, mainly lactobacilli, as a bio-protective tool to counteract genotoxic and mutagenic agents, by biologically inhibiting the related DNA damage in the gut and highlights the emerging perspectives to enlarge and further investigate the microbial bio-protective role at intestinal level.

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