scholarly journals Involvement of oxidative stress in methyl parathion and parathion-induced toxicity and genotoxicity to human liver carcinoma (HepG2) cells

2011 ◽  
Vol 28 (6) ◽  
pp. 342-348 ◽  
Author(s):  
Falicia L. Edwards ◽  
Clement G. Yedjou ◽  
Paul B. Tchounwou
Keyword(s):  
Oxidative Stress ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Methyl Parathion ◽  
Liver Carcinoma

scholarly journals Malathion-induced oxidative stress, cytotoxicity, and genotoxicity in human liver carcinoma (HepG2) cells

2009 ◽  
Vol 25 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Pamela D. Moore ◽  
Clement G. Yedjou ◽  
Paul B. Tchounwou
Keyword(s):  
Oxidative Stress ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Liver Carcinoma

Effects of Amaranthus cruentus L. on aflatoxin B1- and oxidative stress-induced DNA damage in human liver (HepG2) cells

2018 ◽  
Vol 26 ◽  
pp. 42-48 ◽  
Author(s):  
Grace A. Odongo ◽  
Nina Schlotz ◽  
Susanne Baldermann ◽  
Susanne Neugart ◽  
Benard Ngwene ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Aflatoxin B1 ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Amaranthus Cruentus ◽  
And Oxidative Stress

scholarly journals Investigation of Cytotoxicity, Apoptosis, and Oxidative Stress Response of Fe3O4-RGO Nanocomposites in Human Liver HepG2 cells

Materials ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 660 ◽  
Author(s):  
Maqusood Ahamed ◽  
Mohd Javed Akhtar ◽  
M. A. Majeed Khan
Keyword(s):  
Oxidative Stress ◽  
Electron Microscopy ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Molecular Level ◽  
Biological Response ◽  
Cycle Arrest ◽  
Transmission Electron ◽  
Mitochondrial Membrane Potential Loss ◽  
And Oxidative Stress

Iron oxide–reduced graphene oxide (Fe3O4-RGO) nanocomposites have attracted enormous interest in the biomedical field. However, studies on biological response of Fe3O4-RGO nanocomposites at the cellular and molecular level are scarce. This study was designed to synthesize, characterize, and explore the cytotoxicity of Fe3O4-RGO nanocomposites in human liver (HepG2) cells. Potential mechanisms of cytotoxicity of Fe3O4-RGO nanocomposites were further explored through oxidative stress. Prepared samples were characterized by UV-visible spectrophotometer, X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and energy dispersive spectroscopy. The results demonstrated that RGO induce dose-dependent cytotoxicity in HepG2 cells. However, Fe3O4-RGO nanocomposites were not toxic. We further noted that RGO induce apoptosis in HepG2 cells, as evidenced by mitochondrial membrane potential loss, higher caspase-3 enzyme activity, and cell cycle arrest. On the other hand, Fe3O4-RGO nanocomposites did not alter these apoptotic parameters. Moreover, we observed that RGO increases intracellular reactive oxygen species and hydrogen peroxide while decrease antioxidant glutathione. Again, Fe3O4-RGO nanocomposites did not exert oxidative stress. Altogether, we found that RGO significantly induced cytotoxicity, apoptosis and oxidative stress. However, Fe3O4-RGO nanocomposites showed good biocompatibility to HepG2 cells. This study warrants further research to investigate the biological response of Fe3O4-RGO nanocomposites at the gene and molecular level.

scholarly journals The role of oxidative stress in citreoviridin‐induced DNA damage in human liver‐derived HepG2 cells

2013 ◽  
Vol 30 (5) ◽  
pp. 530-537 ◽  
Author(s):  
Yuntao Bai ◽  
Li‐Ping Jiang ◽  
Xiao‐Fang Liu ◽  
Dong Wang ◽  
Guang Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Hepg2 Cells ◽  
Human Liver
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